Epiphany:

Etymology: From Greek "epiphaneia," meaning manifestation or appearance.

Significance: Represents a sudden, profound realization or insight.

Epistemology:

Etymology: Derived from Greek "epistēmē," meaning knowledge.

Significance: Refers to the branch of philosophy that explores the nature and limits of human knowledge.

Epilogue:

Etymology: Comes from Greek "epilogos," meaning conclusion.

Significance: The concluding section of a literary work, providing closure or reflection.

Epitome:

Etymology: Rooted in Greek "epitomē," meaning abridgment or summary.

Significance: Represents a perfect example or embodiment of a particular quality.

Epistolary:

Etymology: Derived from Greek "epistolē," meaning letter.

Significance: Relates to the form of communication through letters or literary works in the form of letters.

Epiphysis:

Etymology: From Greek "epiphysis," meaning growth upon.

Significance: In anatomy, refers to the growth plate at the end of long bones in children.

Epigenetics:

Etymology: Combines Greek "epi-" (over, above) with genetics.

Significance: Study of heritable changes in gene function that do not involve changes to the underlying DNA sequence.

Epicenter:

Etymology: From Greek "epi-" (upon) + "kentron" (center).

Significance: The point on the Earth's surface directly above the earthquake's point of origin.

Epistaxis:

Etymology: Derived from Greek "epi-" (upon) + "stazein" (to drip).

Significance: Medical term for nosebleed.

Epithet:

Etymology: Comes from Greek "epitheton," meaning attributed or added.

Significance: A descriptive term or phrase expressing a quality characteristic of the person or thing mentioned.