By Hannah Went
Don’t understand epigenetics? Don’t worry. There was a time when genetic analysis was hardly known or understood. Now, genetic analysis is performed by thousands of companies and your full genome c
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The podcast currently has 38 episodes available.
In this week’s episode of the Everything Epigenetics podcast, Dr. Christopher Minteer, Nicholas Minteer, and I dive into the fascinating intersection of canine health, longevity, and epigenetics. We explore how their company, Woofgenix, is revolutionizing the field through cutting-edge research and innovative products that aim to extend the lifespan and healthspan of our beloved pets. From understanding the unique epigenetic processes in dogs to uncovering the secrets behind varying breed lifespans, this episode offers insights into how science is shaping a better future for our furry friends.
You'll learn about:
Chapters:
00:00 Introduction
03:00 Meet Dr. Christopher and Nicholas Minteer
09:00 Canine Epigenetics: Comparing Dogs and Humans
16:00 The Science Behind Longevity: Breed and Size Insights
24:00 Woofgenix: Research and Products Revolutionizing Dog Care
36:00 How to Support Canine Aging Research
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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
In this episode of Everything Epigenetics, host Hannah Went sits down with Dave Pascoe, a retired network security architect who’s redefining the way we think about aging. Despite being 62, Dave has been able to have a lower "biological age" and slow pace of aging, a testament to his dedication to health optimization, epigenetics, and biological tuning. Known for ranking among the top contenders in the Rejuvenation Olympics leaderboard, Dave’s journey offers invaluable insights into affordable and effective longevity practices.
You'll learn about:
Chapters:
00:00 – Introduction to Everything Epigenetics and Dave Pascoe
00:16 – Dave’s early experiences and what sparked his interest in health and wellness
02:01 – Rejuvenation Olympics and its goals
05:14 – Dave’s evening and morning routines supporting epigenetic health
08:50 – Dave’s “AHA” moment and lifestyle changes
12:33 – Biohacking techniques and tools for longevity
15:50 – Practical steps for longevity accessible to a broad audience
18:40 – Reflections on balancing stress, mindset, and communityJoin us as we explore practical longevity strategies and learn how you, too, can take control of your health journey!
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
In this week's episode of the Everything Epigenetics podcast, Dr. Chiara Herzog and I talk about how epigenetics is making waves in the medical world and how it could change treatment. Translational scientist and research fellow Dr. Herzog provides insights from her role in the Biomarkers of Aging Consortium and her work on the TirolGESUND project, one of the largest multi-omic human lifestyle intervention trials to date. We investigate the potential applications of epigenetics in cancer detection, aging biomarkers, and preventive measures that could change the paradigm of healthcare from one that is reactive to one that is proactive. We also explore the fascinating potential of using epigenetic markers to anticipate disease before it manifests itself, particularly in the context of cancer research, and how this could impact the delivery of tailored healthcare.
You'll learn about:
Chapters:
00:00 Welcome and introduction
02:30 Dr. Herzog’s journey from neuroscience to epigenetics
05:40 Recent breakthroughs in epigenetic research
12:10 Epigenetics and cancer risk: promising findings
19:15 TirolGESUND study: setup, interventions, and what to expect
27:40 Why studying different cell types matters in epigenetics
32:00 Understanding the exposome and its impact on health
38:20 Future steps for advancing epigenetic biomarkers in healthcare
45:00 Exciting upcoming projects in epigenetics research
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
In this week’s episode of the Everything Epigenetics podcast, Dr. Gabriel Fries and I discuss the fascinating intersections of epigenetics, aging, and psychiatric disorders. Dr. Fries, an Assistant Professor in Psychiatry and Behavioral Sciences at UTHealth, shares his groundbreaking research on the molecular underpinnings of mood disorders such as bipolar disorder and suicide risk. We dive into how psychiatric disorders are linked to accelerated aging, how drugs like lithium show promise in reversing these epigenetic changes, and the future of personalized medicine through pharmacoepigenetics.
You'll learn about:
Chapters:
00:00 – Introduction to Epigenetics and Psychiatry
03:08 – How Epigenetics Mediates Gene-Environment Interactions in Mental Health
06:07 – Epigenetic Aging in Psychiatric Disorders
09:20 – Exploring the Accelerated Aging in Bipolar Disorder and Suicide Risk
17:02 – The Power of Second-Generation Epigenetic Clocks (PhenoAge, GrimAge)
19:45 – What is DunedinPACE? The Pace of Aging and Psychiatric Disorders
23:10 – Lithium’s Anti-Aging Effects in Bipolar Disorder
32:00 – Future Directions: Personalized Medicine Through Pharmacoepigenetics
36:16 – Interventional Drug Trials and Preventing Epigenetic Aging
38:19 – Challenges in the Field and the Need for Longitudinal Studies
42:00 – Final Thoughts: What’s Next for Dr. Fries and His Research
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
Recent research from the University of Chicago shows that only 14% of cancers in the U.S. are diagnosed after the patient had a recommended screening test. 57% of diagnosed cancers do not have screening tests and account for 70% of all cancer-related deaths. 86% of cancer cases still go undiagnosed after recommended screenings. 16M+ life years saved in the U.S. from early-detection screenings. I don't know about you, but everytime I read those stats, my jaw hits the floor.
When it comes to cancer, early detection is key to saving lives. With 610,000+ cancer deaths in the U.S. each year, most of which stemming from cancer types with no FDA-approved screening options, new technology is making revolutionary strides in detecting cancers that have been previously undetectable in early stages.
There are now new tools intended to be used complementary to established cancer screening assessments. However in some cases, especially for cancer types that have no previously established screening test and are notoriously hard to detect, it may be the only warning sign currently available for providers.
In this week’s episode of the Everything Epigenetics podcast, Dr. Joshua Routh and I talk about just that. We discuss the rising cancer burden and the cutting-edge role epigenetics plays in revolutionizing early cancer detection. Dr. Routh, a molecular genetic pathologist and medical director at Precision Epigenomics, shares insights into how new diagnostics, such as Multi-Cancer Detection (MCD) tests, provide opportunities to catch cancers earlier than ever before. We also explore the technology behind these tests, their impact on patient outcomes, and what the future holds for epigenetics in diagnosing and treating cancer and other chronic diseases.
You'll learn about:
What to expect if you get a positive cancer result and how recurrence monitoring works.
The broader future of epigenetics in treating conditions like heart disease and neurological disorders.
Chapters:
00:10 - Introduction to Dr. Joshua Routh and His Career Journey
04:48 - The Growing Cancer Burden and Challenges in Screening
09:00 - How Epigenomics is Transforming Early Cancer Detection
13:12 - Multi-Cancer Detection Tests: What Are They?
18:22 - EPISEEK by Precision Epigenomics vs. Galleri: Comparing the Leading Tests
25:27 - Cancer Therapy Resistance and the Role of Epigenet
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
In this week’s episode of the Everything Epigenetics podcast, I’m joined by Dr. Charles Breeze, an expert in computational epigenetics. We talk about his inspiring journey into the field of epigenetics, his trailblazing research on kidney function across diverse ethnic groups, and the innovative tools he's developed to push the boundaries of epigenetic research.
Dr. Breeze shares how his fascination with the complex interaction between environmental and genetic factors shaped his path into epigenetics. This passion led him to focus on understanding why certain populations are at higher risk for diseases like chronic kidney disease. His work has uncovered insights into the disparities in kidney disease risk among different ethnic groups, shedding light on genetic and environmental factors that had previously been overlooked.
To address the challenges of inclusivity and precision in epigenetic studies, Dr. Breeze developed specialized tools that enhance the accuracy of Epigenome-Wide Association Studies (EWAS). These tools aim to improve how we analyze the impact of genetics and environment on health, helping researchers study epigenetic patterns across populations more effectively. His contributions are making it easier to identify how factors like diet, stress, and pollution affect gene expression, paving the way for more inclusive and equitable health research.
Dr. Breeze earned his Ph.D. in computational epigenetics and genomics from University College London, where he was a Marie Curie fellow. He has also worked at top institutions like the University of Oxford, the European Bioinformatics Institute, and the Altius Institute for Biomedical Sciences in Seattle. There, he led the analysis and creation of important mouse genome data. Dr. Breeze has developed bioinformatics tools like eFORGE and FORGE2, which help analyze data from studies on how genes and the environment affect health (EWAS and GWAS). Dr. Breeze is a member of the Encyclopedia of DNA Elements (ENCODE) and the International Human Epigenome Consortium (IHEC).
You’ll learn about:
- Dr. Breeze’s early interest in genomics, sparked by reading "Genome" by Matthew Ridley
- His significant findings from the 2021 study titled “Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci,” which revealed ethnic disparities in kidney function
- The challenges faced in epigenetic research due to the lack of diversity in reference data and how this impacts research outcomes
- Proposed solutions to increase diversity in epigenomic data, including community involvement and targeted data generation
- How his bioinformatics tools, eFORGE and FORGE2, assist researchers in understanding the complex data from EWAS and GWAS studies
- His future research directions, including studies on kidney cancer and the expansion of pathway analysis tools
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
Alzheimer’s disease is a devastating neurodegenerative condition that slowly erodes memory, cognitive function, and the ability to perform even the simplest tasks. It’s heartbreaking not only for those diagnosed but also for their loved ones as they watch a gradual loss of the person they knew. This is exactly how I felt in 2015 when I watched my grandmother be taken by this awful disease.
The disease progresses as abnormal protein deposits (amyloid plaques and tau tangles) damage brain cells, leading to widespread brain shrinkage. Despite ongoing research, effective treatments remain limited, making Alzheimer’s one of the most challenging and impactful diseases today. However, new research is uncovering fresh perspectives on its underlying causes. One emerging view is that beyond the traditional focus on protein deposits, epigenetic changes might play a crucial role in driving the disease.
In this week’s episode of the Everything Epigenetics podcast, Dr. Katz and I focus on his labs surprising journey that led them to believe that Alzheimer’s disease is an epigenetic disease resulting from a loss of cell fate. Dr. Katz anticipates that his lab’s work will advance drug discovery through epigenetics. If no other company exploits the work, his will, even though it currently exists only on paper. “Most of the epigenetic drugs are cancer therapies,” he notes. “More recently, drugs that target epigenetic enzymes have been pursued for a wide range of diseases, ranging from muscular dystrophies to Alzheimer’s disease. Going forward, it will be exciting to see if epigenetic-based therapies prove to be effective against other diseases.”
You’ll learn about:
Chapters:
00:00 Introduction to Epigenetics
07:50 Hannah’s Insights on Recent Research
15:55 David’s Perspective on Practical Applications
25:18 The Impact of Lifestyle on Epigen
Support the show
Where to Find Us:
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Follow us on:
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
In this week’s episode of the Everything Epigenetics podcast, Hannah Went sits down with Alex Trapp, a computational biologist deeply involved in aging research. The two explore the cutting-edge development of single-cell epigenetic clocks and their potential applications in the field of longevity science. Alex shares his journey from experimental biology to computational approaches and discusses the significant implications of understanding aging at the single-cell level. He also provides insights into his work at Retro Biosciences, a company focused on extending healthy human lifespan through innovative therapies.
In this episode of Everything Epigenetics, you’ll learn about:
• The development and significance of single-cell epigenetic clocks
• Differences between bulk tissue and single-cell epigenetic sequencing methods
• Applications of single-cell aging clocks in understanding and potentially reversing aging
• Challenges and future directions in single-cell epigenetic research
• The exciting work being done at Retro Biosciences, including advancements in T-cell rejuvenation and plasma therapeutics
Chapters:
00:00 Introduction
03:15 Alex Trapp's journey in the aging research field
07:35 Overview of epigenetic clocks and single-cell approaches
17:38 Development and challenges of the single-cell aging clock
22:41 Applications and implications of single-cell clocks in aging research
35:57 Future directions in epigenetic research
42:55 Alex's work at Retro Biosciences and its potential impact
Review Alex’s Study: https://pubmed.ncbi.nlm.nih.gov/36211119/
Support the Show: https://www.buzzsprout.com/2084028/support
Support the show
Where to Find Us:
Instagram
Follow us on:
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
The development and application of epigenetic predictors of health is revolutionizing the way we understand and approach personalized medicine. These predictors, derived from analyzing DNA methylation patterns, provide a powerful tool for assessing biological age, disease risk, and overall health.
By leveraging advanced machine learning and AI, researchers can identify specific epigenetic markers that correlate with various health outcomes, allowing for early detection and tailored interventions.
The ability to accurately predict health outcomes and aging processes not only offers individuals a roadmap for healthier living but also promises to reduce healthcare costs by focusing on prevention rather than treatment.
In this week’s episode of the Everything Epigenetics podcast, Dr. Varun Dwaraka and I discuss practical applications of epigenetics, such as the development of epigenetic clocks for measuring biological age. We explain the concept of epigenetic clocks and the different generations of these clocks, emphasizing the importance of reproducibility and association with clinical outcomes.
Varun also introduces how machine learning and AI are used to create Epigenetic Biomarker Proxies (EBPs), developed in collaboration by TruDiagnostic and Harvard, which can provide detailed health insights from a single blood sample. We also cover the significant implications of EBPs, including cost reduction and personalized supplement recommendations from a single blood sample.
In addition, we compare methylation risk scores to epigenetic biomarker proxies, providing a clear understanding of their differences and applications.
Lastly, Varun shares current exciting areas of discovery and ongoing projects, offering a glimpse into the future of epigenetic research and its potential to revolutionize personalized health.
Varun is currently the Head of Bioinformatics at TruDiagnostic and sits on the faculty at the Geneva College of Longevity Science.
In this episode of Everything Epigenetics, you’ll learn about:
Chapters:
00:00 Introduction and Commendation
05:21 The Growth of Epigenetics
11:41 Defining Epigenetic Clocks
14:08 Best Bioinformatic Practices
24:55 Stochastic Aging vs Dynamic Aging
26:49 Best Practices in Bioinforma
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Where to Find Us:
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
In Europe, people aged 65 typically spend about half of their remaining years managing disabilities. Much of the existing research on aging has predominantly focused on identifying "cures" rather than exploring strategies for healthy aging. Dr. Esther Walton’s is breaking new frontiers with the unconventional approach that aging begins at birth and should be approached through a comprehensive life course strategy that integrates studies of early development, adult psychiatry, and mental aging in later life. Her research program, BrainHealth, aims to fundamentally redefine, enhance, and distinguish mental aging throughout the lifespan by examining patterns of mental aging within the innovative framework of 'brain health'.
With the BrainHealth program, Esther hopes to:
1) characterize brain health from birth to old age by establishing robust predictors of brain health in childhood and adolescence
2) improve brain health by identifying modifiable protective factors to enhance brain health across the life course
3) differentiate between physical and mental aging by developing a tissue-specific mouse model of lifelong brain health.
If successful, this program will revolutionize the approach to healthy aging by permitting the early identification and alteration of unhealthy aging trajectories - a key societal challenge of our time.
In this week’s Everything Epigenetics podcast episode, we explore the fascinating intersection of brain health and epigenetics with Dr. Esther Walton, Associate Professor in Clinical Psychology at the University of Bath. Dr. Walton discusses her pioneering work on DNA methylation and its crucial role in brain development and mental health. This is especially exciting because little is known about the extent to which DNA methylation is linked to individual differences in the brain itself, and how these associations may unfold across development - a time of life when many mental disorders emerge. By combining epigenetics with advanced neuroimaging techniques, her studies continue to uncover how these epigenetic modifications affect brain structure and function over time.
In this episode of Everything Epigenetics, you’ll learn about:
Support the show
Where to Find Us:
Instagram
Follow us on:
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Visit our website for more information and resources: everythingepigenetics.com
Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.
The podcast currently has 38 episodes available.
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