Aging is a complex process, but have you ever wondered how it differs between men and women? In this week’s episode of the Everything Epigenetics podcast, Sara Hägg, an Associate Professor at Karolinska Institutet, and I discuss the fascinating differences in biological aging between sexes. We explore how genetics, hormones, and lifestyle choices contribute to aging disparities and what that means for longevity, disease risk, and overall health.

You'll learn about:
- How Sara Hägg became interested in aging research and what led her to study sex-specific differences
- The major ways men and women age differently at the genetic, molecular, and epigenetic levels
- The role of hormones like estrogen and testosterone in shaping the aging process
- Why women typically live longer than men and what factors influence this disparity
- How stress, diet, and environmental exposures impact aging uniquely for men and women
- The latest epigenetic research uncovering biological sex differences in aging
- How precision medicine may help tailor aging interventions based on sex-specific needs
- Biomarkers of aging and how they reveal crucial insights into longevity and healthspan

Chapters:
00:00 – Introduction to Everything Epigenetics Podcast
00:05 – Meet Sara Hägg: Her Background and Research Focus
02:30 – What Inspired Her to Study Aging and Sex Differences
06:30 – How Do Men and Women Age Differently?
10:00 – The Role of Hormones: Estrogen, Testosterone, and Aging
14:00 – Why Do Women Live Longer Than Men?
19:30 – Cellular and Epigenetic Differences in Male vs. Female Aging
24:00 – The Impact of Stress, Diet, and Environment on Aging
29:00 – Age-Related Diseases: Which Are More Common in Men vs. Women?
33:00 – How Biomarkers Help Predict Aging and Disease Risk
37:00 – The Future of Precision Medicine in Aging
40:00 – Surprising Findings from Sara Hägg’s Research & Closing Thoughts

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

Epigenetics offers fascinating insights into how our genes are influenced by lifestyle and environmental factors. In this week’s episode of the Everything Epigenetics podcast, Dr. Raffaele Teperino and I delve into groundbreaking research on epigenetic inheritance and how reproductive fitness impacts long-term health. From the transfer of epigenetic material during conception to the role of paternal health in childhood obesity and diabetes risk, we discuss how these factors shape generational health outcomes.

You'll learn about:
• The role of epigenetics in reproductive fitness and how it goes beyond reproductive capacity.
• How sperm and eggs transfer more than just DNA, influencing offspring development through epigenetic material.
• The surprising impact of paternal health at conception on childhood obesity and metabolic disorders.
• The importance of lifestyle changes before conception to improve offspring health.
• Practical insights into integrating epigenetics into preventive medicine and public health.

Chapters:
00:00 Welcome & Introduction
01:09 Dr. Teperino’s journey into epigenetics and its link to complex diseases.
03:56 Understanding reproductive fitness and its connection to epigenetics.
08:33 The transfer of epigenetic material from sperm to oocyte.
17:01 The role of paternal health in shaping offspring health risks.
24:07 Longitudinal studies on early-life risks of obesity and diabetes.
37:44 The overlooked role of seminal plasma in reproductive health.
42:00 The future of epigenetics: Neurodevelopmental disorders and preventive health.
45:32 Closing thoughts and where to connect with Dr. Teperino.

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

DNA methylation, a cornerstone of epigenetic research, is vital for understanding gene regulation and its implications in health and disease. In this week’s episode of the Everything Epigenetics podcast, I speak with David Goldberg and Nicole Renke about the latest advancements in DNA methylation tools, including Illumina's groundbreaking Methylation Screening Array (MSA).

We explore the history and evolution of methylation microarrays, why they remain the gold standard for Epigenome-Wide Association Studies (EWAS), and the design process behind the MSA array. David and Nicole provide insight into the practical applications of these tools for research in aging, neurodegenerative disorders, and environmental exposures.

You'll learn about:
•⁠  ⁠What methylation microarrays are and why they’re essential for EWAS
•⁠  ⁠The market need and vision for Illumina's new MSA array
•⁠  ⁠Key features and benefits of the MSA array for researchers
•⁠  ⁠The role of cell-specific methylation in advancing epigenetic studies
•⁠  ⁠Insights into the technical and biological validation of the MSA array

Chapters:
00:00 Welcome and Introduction
02:30 History of Methylation Microarrays
10:45 Applications of EWAS in Research
20:15 Unveiling the MSA Array: Vision and Design
35:00 Technical Validation and Biological Insights
45:30 Future Directions in DNA Methylation Research
50:00 Closing Remarks

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

How can epigenetics revolutionize heart disease prevention? In this week’s episode of the Everything Epigenetics podcast, Dr. Meesha Dogan and I discuss the groundbreaking role of AI-driven epigenetics in cardiovascular medicine. Dr. Dogan shares her journey into the field, the life-changing potential of precision diagnostics, and the critical connection between lifestyle and heart health.

You'll learn about:
•⁠  ⁠How epigenetics determines heart disease risk beyond genetics.
•⁠  ⁠The role of AI in identifying biomarkers and enabling earlier interventions.
•⁠  ⁠Real-world applications of personalized treatment plans informed by epigenetic testing.
•⁠  ⁠Why behavior changes, guided by dynamic DNA data, are key to long-term heart health.
•⁠  ⁠The future of epigenetics in drug development and preventative medicine.
Chapters:
00:00 Introduction
03:00 Dr. Meesha Dogan’s journey into epigenetics and personalized health
10:00 How epigenetics informs heart disease risk and prevention
18:00 AI’s transformative role in cardiovascular diagnostics
26:00 Real-world applications: Precision CHD tests and success stories
35:00 Lifestyle interventions and the power of behavioral insights
45:00 The future of epigenetic research: Drug development and dynamic testing

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

Reproductive longevity and fertility are topics that impact women disproportionately across the globe. In this week’s episode of the Everything Epigenetics podcast, Dr. Katherine Zagone and I discuss how epigenetics can unlock key insights into fertility, biological age, and reproductive health. Dr. Zagone shares her journey into the fertility world, her pioneering work at Clockwize, and how biological age plays a crucial role in fertility outcomes.

You'll learn about:

• How Dr. Zagone founded Clockwize and what inspired her focus on fertility.
• The importance of biological age over chronological age in predicting fertility outcomes.
• Clockwize’s "Fertility Wise Test" and how it measures biological aging and exposure to fertility toxins.
• Common fertility toxins, including phthalates, BPA, and parabens, and how to reduce exposure.
• The FAST framework (Food, Fitness, Associated conditions, Sleep, Stress, Trauma, and Toxins) to optimize fertility and rewind biological age.
• Future innovations in epigenetic fertility predictions and outcomes.

Chapters:
00:00 Introduction
02:00 State of Reproductive Longevity and Its Disproportionate Impact on Women
05:00 Dr. Katherine Zagone’s Journey into Fertility and Founding Clockwize
10:30 Biological Age vs. Chronological Age in Fertility
15:00 How Epigenetics Can Predict Fertility and Health Outcomes
20:00 The FAST Framework: Rewinding Your Biological Clock
25:00 Identifying and Reducing Exposure to Fertility Toxins
30:00 Innovations and Future Directions in Fertility Epigenetics
40:00 Success Stories and Real-World Impacts

50:00 How to Connect with Dr. Zagone and Learn More About Clockwize

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

What does it take to live not just longer but healthier lives? In this week’s episode of the Everything Epigenetics podcast, Dr. Jamie Justice and I explore the groundbreaking research and initiatives shaping the future of healthy aging. From bridging the gap between lifespan and healthspan to revolutionary breakthroughs like the XPRIZE Healthspan prize, we dive deep into the science and innovations driving progress in geroscience.

You'll learn about:

• What “healthy aging” truly means and why it’s vital for everyone.
• How the gap between lifespan and healthspan impacts society and what can be done to close it.
• The critical factors influencing long-term healthspan and actionable steps individuals can take.
• The goals and potential of the XPRIZE Healthspan initiative and the exciting innovations emerging from it.
• How targeted initiatives like the SOLVE FSHD Bonus Prize could shape the future of disease-specific health research.
• A look ahead: breakthroughs and milestones expected in the next 5-10 years in aging research.

Chapters:
00:00 Welcome and Introduction
02:30 What “healthy aging” means to Dr. Jamie Justice
07:15 Lifespan vs. Healthspan: Bridging the gap
15:40 Key factors influencing long-term healthspan
22:10 Overview of the XPRIZE Healthspan Prize
28:45 Promising innovations from XPRIZE participants
35:20 The SOLVE FSHD Bonus Prize and its impact
42:10 Future breakthroughs in geroscience and aging research
49:30 Where to connect with Dr. Jamie Justice

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

In this week’s episode of the Everything Epigenetics podcast, Dr. Christopher Minteer, Nicholas Minteer, and I dive into the fascinating intersection of canine health, longevity, and epigenetics. We explore how their company, Woofgenix, is revolutionizing the field through cutting-edge research and innovative products that aim to extend the lifespan and healthspan of our beloved pets. From understanding the unique epigenetic processes in dogs to uncovering the secrets behind varying breed lifespans, this episode offers insights into how science is shaping a better future for our furry friends.

You'll learn about:

• How Woofgenix uses epigenetic testing to enhance canine longevity.
• The surprising ways epigenetic processes in dogs differ from humans.
• Exciting breakthroughs in canine aging research, including the role of rapamycin.
• Woofgenix's innovative products like WoofAge, WoofSpan, and Woof Wellness.
• How dog lovers can get involved in longevity research through citizen science initiatives.

Chapters: 

00:00 Introduction

03:00 Meet Dr. Christopher and Nicholas Minteer

09:00 Canine Epigenetics: Comparing Dogs and Humans

16:00 The Science Behind Longevity: Breed and Size Insights

24:00 Woofgenix: Research and Products Revolutionizing Dog Care

36:00 How to Support Canine Aging Research

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

In this episode of Everything Epigenetics, host Hannah Went sits down with Dave Pascoe, a retired network security architect who’s redefining the way we think about aging. Despite being 62, Dave has been able to have a lower "biological age" and slow pace of aging, a testament to his dedication to health optimization, epigenetics, and biological tuning. Known for ranking among the top contenders in the Rejuvenation Olympics leaderboard, Dave’s journey offers invaluable insights into affordable and effective longevity practices.

You'll learn about:

• Dave’s routines and habits for maintaining youthful epigenetic markers
• The Rejuvenation Olympics: what it is and how Dave has made his mark
• How personalized routines and lifestyle changes can slow down aging

Chapters:
00:00 – Introduction to Everything Epigenetics and Dave Pascoe
00:16 – Dave’s early experiences and what sparked his interest in health and wellness
02:01 – Rejuvenation Olympics and its goals
05:14 – Dave’s evening and morning routines supporting epigenetic health
08:50 – Dave’s “AHA” moment and lifestyle changes
12:33 – Biohacking techniques and tools for longevity
15:50 – Practical steps for longevity accessible to a broad audience
18:40 – Reflections on balancing stress, mindset, and communityJoin us as we explore practical longevity strategies and learn how you, too, can take control of your health journey!

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

In this week's episode of the Everything Epigenetics podcast, Dr. Chiara Herzog and I talk about how epigenetics is making waves in the medical world and how it could change treatment. Translational scientist and research fellow Dr. Herzog provides insights from her role in the Biomarkers of Aging Consortium and her work on the TirolGESUND project, one of the largest multi-omic human lifestyle intervention trials to date. We investigate the potential applications of epigenetics in cancer detection, aging biomarkers, and preventive measures that could change the paradigm of healthcare from one that is reactive to one that is proactive. We also explore the fascinating potential of using epigenetic markers to anticipate disease before it manifests itself, particularly in the context of cancer research, and how this could impact the delivery of tailored healthcare.

You'll learn about:

• How Dr. Herzog’s background in neuroscience led her to epigenetics
• Recent breakthroughs in epigenetics and why they are promising for healthcare
• The potential of epigenetic markers to predict cancer risk and diagnose early stages of cancer
• The setup and goals of the TirolGESUND study focusing on intermittent fasting and smoking cessation
• The importance of studying epigenetic changes across different cell types and understanding the exposome
• How the exposome interacts with our epigenome and its implications for personalized medicine

Chapters: 
00:00 Welcome and introduction
02:30 Dr. Herzog’s journey from neuroscience to epigenetics
05:40 Recent breakthroughs in epigenetic research
12:10 Epigenetics and cancer risk: promising findings
19:15 TirolGESUND study: setup, interventions, and what to expect
27:40 Why studying different cell types matters in epigenetics
32:00 Understanding the exposome and its impact on health
38:20 Future steps for advancing epigenetic biomarkers in healthcare
45:00 Exciting upcoming projects in epigenetics research

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

In this week’s episode of the Everything Epigenetics podcast, Dr. Gabriel Fries and I discuss the fascinating intersections of epigenetics, aging, and psychiatric disorders. Dr. Fries, an Assistant Professor in Psychiatry and Behavioral Sciences at UTHealth, shares his groundbreaking research on the molecular underpinnings of mood disorders such as bipolar disorder and suicide risk. We dive into how psychiatric disorders are linked to accelerated aging, how drugs like lithium show promise in reversing these epigenetic changes, and the future of personalized medicine through pharmacoepigenetics.

You'll learn about:

• The importance of epigenetics in psychiatric disorders
• How psychiatric disorders accelerate the aging process
• The anti-aging effects of lithium in bipolar patients
• How epigenetic markers can help predict treatment responses
• The future of interventional trials aimed at reversing epigenetic aging
• The challenges facing the field and the need for replication studies

Chapters:
00:00 – Introduction to Epigenetics and Psychiatry
03:08 – How Epigenetics Mediates Gene-Environment Interactions in Mental Health
06:07 – Epigenetic Aging in Psychiatric Disorders
09:20 – Exploring the Accelerated Aging in Bipolar Disorder and Suicide Risk
17:02 – The Power of Second-Generation Epigenetic Clocks (PhenoAge, GrimAge)
19:45 – What is DunedinPACE? The Pace of Aging and Psychiatric Disorders
23:10 – Lithium’s Anti-Aging Effects in Bipolar Disorder
32:00 – Future Directions: Personalized Medicine Through Pharmacoepigenetics
36:16 – Interventional Drug Trials and Preventing Epigenetic Aging
38:19 – Challenges in the Field and the Need for Longitudinal Studies
42:00 – Final Thoughts: What’s Next for Dr. Fries and His Research

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Visit our website for more information and resources: everythingepigenetics.com

Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.