DNA methylation, a cornerstone of epigenetic research, is vital for understanding gene regulation and its implications in health and disease. In this week’s episode of the Everything Epigenetics podcast, I speak with David Goldberg and Nicole Renke about the latest advancements in DNA methylation tools, including Illumina's groundbreaking Methylation Screening Array (MSA).

We explore the history and evolution of methylation microarrays, why they remain the gold standard for Epigenome-Wide Association Studies (EWAS), and the design process behind the MSA array. David and Nicole provide insight into the practical applications of these tools for research in aging, neurodegenerative disorders, and environmental exposures.

You'll learn about:
•⁠  ⁠What methylation microarrays are and why they’re essential for EWAS
•⁠  ⁠The market need and vision for Illumina's new MSA array
•⁠  ⁠Key features and benefits of the MSA array for researchers
•⁠  ⁠The role of cell-specific methylation in advancing epigenetic studies
•⁠  ⁠Insights into the technical and biological validation of the MSA array

Chapters:
00:00 Welcome and Introduction
02:30 History of Methylation Microarrays
10:45 Applications of EWAS in Research
20:15 Unveiling the MSA Array: Vision and Design
35:00 Technical Validation and Biological Insights
45:30 Future Directions in DNA Methylation Research
50:00 Closing Remarks

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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.