Evolving Past Alzheimer's

Evolving Past Alzheimer's

By Evolving Past Alzheimer'sMedicineAlternative HealthHealth & Fitness
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Evolving Past Alzheimer's episodes

  • Introducing the Brain Health Coach with Ryan Glatt

    Deep Conversation on Brain Health Coaching and finding your edge, with brain health coach extraordinaire.

    To contact Ryan Glatt or to find out more about the services he offers go to Somatiq.com or Ryanglatt.com. You can follow him on Instagram @glatt.somatiq

    59 min
  • 1+1=3...Stacking Brain & Body Exercises. What's The Evidence?

    Dr McEwen explains her study of older adults with cognitive decline and begins by explaining what are the subjective assessment she used in her studies to label cognitive decline. The effects on cognitive functioning social experience and physical challenge of a group exercise class was the focus of the study. Discussion of what is similar and difference between psychosis and Alzheimer's. The discussion to turns to how Dr McEwen ties together all the various indicators she is researching and the CogFit exercise program is laid out. Dr McEwen also works at Genius Gyms and helps translate some of her research into practical applications for a variety of people who could benefit from the cognitive training. She is also help to develop an app that help people do these exercises on their own as well. The discussion concludes talking about the other ways these exercises can help with emotional, attentional or executive function problems by addressing underlying cognitive problems.

    Dr. Sarah McEwen is a Cognitive Psychologist, the Director of Research and Programming at Saint John's - Pacific Brain Health Center in Santa Monica, CA.

    47 min
  • Neuropsychology is Important in Alzheimer's and Cognitive Function - Here's Why

    We're back on track...here's a really helpful discussion covering why neuropsychological testing is important if you are dealing with memory loss, cognitive impairment, Alzheimer's, Traumatic Brain Injury, and even problems with mood (such as anxiety and depression).

    Kristine Lokken PhD is a functional neuropsychologist with a passion for helping people restore brain health. Her extensive background in clinical research, medical neuropsychology, and holistic wellness merged together to create the Brain Health Institute (BHI). In addition to her work at BHI, she served as the Director of the Rehabilitation Neuropsychology Service at the Birmingham VA Medical Center and instructed as a Clinical Assistant Professor at University of Alabama at Birmingham. She has maintained a private practice for over 15 years, and has seen thousands of patients with varying neurological and psychological issues in her clinical work. Dr. Lokken has published several articles in peer reviewed journals and has lectured extensively on brain health. Since the time of the recording of this episode Dr Lokken has relocated to Seattle, WA to be part of the Brain Health and Research Institute.

    Neuropsychologic testing is essential to make a diagnosis of Alzheimer's or other dementia. This episode explores the role of a Neuropsychologist in a holistic approach to cognitive care. Our discussion begins by focusing basic definitions within the field of neuropsychology. We discuss what is coming down the line in terms of early recognition of Alzheimer's from a neuropsychologist's perspective. Later we take a deeper dive into the best tests or areas to test for early recognition. We touch on some of Dr Lokken's recently presented evidence that homocysteine may be one of the more useful and affordable biomarkers to look at.

    Dr Lokken talks about the value of online cognitive tests versus being evaluated by a Neuropsychologist. The discussion continues by looking at self-reported cognitive decline and what you can do if you feel you are worried about it. We finish talking about how the medical community has changed its perspective on prevention going back to the end of 2018 and what is possible in the future in terms of prevention.

    50 min
  • Welcome to Season 2. We're back and talking Alzheimer's, longevity and more!

    Dr Nate Bergman welcomes you back for season 2 of the Evolving Past Alzheimer's Podcast. This season we're talking Neuropsychology, new approaches that incorporate both the brain and body for better results, begin talking about transcranial electric stimulation approaches to Alzheimer's and issues of cognition. We will also continue to discuss ways to optimally age in our bodies while our minds and spirits continue to soar!

    8 min
  • Dr Sara Gottfried - Women, Perimenopause, and Alzheimer's Disease
    Sara Gottfried M.D. is a mother, wife, Harvard-educated physician, keynote speaker, and author of three New York Times bestselling books, The Hormone Cure (2012), The Hormone Reset Diet (2015), and her latest book Younger: A Breakthrough Program to Reset Your Genes, Reverse Aging, and Turn Back the Clock 10 Years (2017). For the past 25+ years, Dr. Sara has been dedicated to helping women feel at home in their bodies with functional medicine. After graduating from Harvard Medical School and MIT, she completed her residency at the University of California at San Francisco. She lives in Berkeley, California with her family. Dr Sara, shares what she learned from her own journey towards health highlighting how jumping straight to bioidentical hormone therapy isn't always the best option. Dr Sara lays out the issues of hormones in perimenopausal and the implications in Alzheimer's disease. The dramatic hormone shifts in perimenopause into the menopausal transition make women more vulnerable to Alzheimer's disease. We discuss the concepts of bioenergetics, glucose "hypometabolism" and mitochondrial changes in pre, peri, and postmenopausal changes. The premenopausal state is protective against brain changes leading to Alzheimer's. The HPA axis, or the control system for stress and hormone system, becomes dysregulated. Dr Sara describes how symptoms such as anxiety and depression may in fact may not be the diseases themselves, but harbingers of Alzheimer's and cognitive impairment. Dr Sara's Basics for Estrogen and Hormone Balance:
    • Food choices: basics of water, increased fiber, magnesium
    • Assessing nutrient gaps (organic acid panels, essential fatty acid, oxidative stress panel)
    • Assessment of microbiome (looking for infection, dysbiosis, beta-glucuronidase, etc) with Functional stool testing.
    • Looking at Estrogen metabolism (estrone, estradiol, estrone)
      • this can be done with dried urine testing and other testing to determine how your body is breaking down estrogen and if it is getting rid of it efficiently
      • stool testing with beta-glucuronidase
    • An approach to identifying and actively managing stress and to develop stress resilience
      • Using a the Perceived Stress Scale to assess
      • Measure blood cortisol, dried urine testing
    • Core supplementation: magnesium, DIM (di-indolylmethane).
    • Advanced maneuvers (of course, in the context of overall lifestyle changes)
      • Phosphatidylserine 300-400mg - in divided doses or all at once or at bedtime
      • Lavela (pill form of Lavender) for anxiousness - can get on Amazon
      • Chasteberry - helps perimenopausal women who still get a menstrual cycle. Helps raise progesterone (a neurosteroid that helps to soothe the female brain). note: this can take 2-4 weeks to see a change
        • Dr Sara often recommends: "Fertility Blend" brand name
    When does Dr Sara move to using bioidentical hormone replacement? after basic lifestyle changes:
    • Step 1: Navigate stress (less coffee and alcohol). add flax seeds to a morning shake/smoothie (eg 2 tablespoons)
    • Step 2: Chasteberry, Siberian rhubarb, Maca (see Dr Sara's books esp The Hormone Cure for doses and timing and alot more strategy)
    • Step 3: Consider bioidentical hormones
      • estradiol patch with micronized progesterone esp for perimenopausal women. she tries to use the lowest dose for the shortest time possible. she see's about 10% of her patients end up going on hormone replacement.
    Towards the end of the interview (minute 50) we take a fairly deep dive into using bioidentical hormone therapy in women that are a bit older than perimenopausal ages and the controversy surrounding this issue. Dr Sara also lets the cat out of the bag with a new book on Brain that's coming out soon! listen towards the end of the interview for that. "The Brain, Body Diet" - a Functional Medicine approach. For more information Visit Dr Sara's website at: saragottfriedmd.com Also read her recent article on Women, Hormones, and Alzheimer's.
    57 min
  • The Alzheimer's Solution with Dr Dean and Dr Ayesha Sherzai
    As Co-Directors of the Alzheimer's Prevention Program at Loma Linda University Medical Center, Dr. Ayesha and Dr. Dean Sherzai, through research and their extensive collective medical backgrounds, work to demystify the steps to achieving long-term brain health and the prevention of devastating diseases such as Alzheimer's and dementia. They are also the authors of the much acclaimed book, The Alzheimer's Solution: A Breakthrough Program to Prevent and Reverse the Symptoms of Cognitive Decline at Every Age They call their basic program NEURO which stands for, Nutrition Exercise Unwind (from stress) Restorative sleep Optimize cognitive and social activity. Currently TeamSherzai works at Loma University, the only recognized Blue Zone in the United States. They are currently studying how the Loma Linda community, which is largely a vegetarian-based, health-focused community has such a significantly lower number of cases of Alzheimer's. We discuss the role of "good" vs "bad" fats and an expanded scoring system to determine the best diet to avoid the risk of strokes and brain damage. The highlights from this episode we discuss:
    • omega 3 fatty acid supplements
    • tofu/soy
    • organic vs non-organic (simple key: try to know where your food comes from)
    • proton pump inhibitors (ant-acid medications)
    • statin (anti-cholesterol medications)
    • the relationship between vascular disease (blood vessel issues) PREceding Alzheimer's
    • Dose of exercise - 20-35 minutes per day. 4-5 days a week. to the point of mild breathlessness/pointing. Also, leg strength seems to correlate with brain strength.
    • "Living a Purpose Driven Life" - Team Sherzai has found that to enhance cognitive/neuronal "connectivity" is to sustain a combination of ongoing complexity, challenge and connection to a larger purpose. Keep these in mind as we make our decisions in the 2nd half of life!
    • Experimental labs/biomarkers for brain and neurodegenerative disease (exosomes, oxidation family, VEGF)
    Find more about Drs Dean & Ayesha Sherzai's work in their new book - The Alzheimer's Solution
    1 hr 5 min
  • Inhalational Alzheimer's - Is mold illness real? with Mary Ackerley Part 2 - Treatments
    We are going to pick up where we left off last week talking to Dr Mary Ackerley about mold and the phenomenon called Inhalational Alzheimer's. Last week we spoke about the diagnosis side of mold related cognitive impairment. this week we speak about treatments. For the second part of the show we pick up where we left off talk about a program that is available online called,The Dynamic Neural Retraining System. -Step One Remediation- you have to get away from the mold/mycotoxin/biotoxin exposure. Make sure to use a qualified Indoor Environmental Professional (IEP). This can often be the most difficult -Step Two Basic Treatment
    • binders such as cholestyramine, clay, charcoal and other
    • assessing and treating MARCoNS - a colonization of a certain type of staph infections. can be treated by specific nasal sprays or ozone.
    • addressing hormones - such as estrogen, DHEA, testosterone.
    • VIP (vasoactive intestinal peptide) - a natural hormone. this perhaps encourage the growth of grey matter in the brain (FDA safety data has not yet been shown).
    -Step Three Advanced Treatment
    • in cases beyond simpler mold/mycotoxin cases into coinfections. This includes looking deeper at hormones or infections or parasites.
    • addressing Mast cell activation/Histamine issues - gut issues, flushing, itching, tongue and throat swelling, POTS (postural orthostatic tachycardia syndrome), dysautonomia.
    • dealing with patient with Traumatic Brain Injury or serious psychiatric illness
    Dr Ackerley is a co-founder of ISEAI, the International Society of Environmentally Acquired Illness. Society members are dedicated to researching and quantifying symptoms and treatment approaches from biotoxin mediated inflammatory illness.
    39 min
  • Inhalational Alzheimer's - Is mold illness real? with Mary Ackerley Part 1 - Assessments
    Our guest today is Dr Mary Ackerley MD, Dr Ackerly is a Harvard and Johns Hopkins trained board certified psychiatrist. She holds active medical licenses in Arizona and Florida. Mary also is a co-founder of ISEAI, the International Society of Environmentally Acquired Illness. Society members are dedicated to researching and quantifying symptoms and treatment approaches from biotoxin mediated inflammatory illness. She is probably most well known for her internet article entitled "Brain on Fire" (related YouTube) which is a summary of the neuropsychiatric implications of biotoxin illness and her practice My Passion 4 Health is located in Arizona. She was also a co-author on an article with a previous guest, Dr Dale Bredesen called, Reversal of Cognitive Decline in Alzheimer's Disease. - this was sort of an expose of a novel concept called, Inhalational Alzheimer's. Disclaimer: please note, this show like all shows on the podcast is not meant to be medical advice. it is not intended to diagnose or treat any health condition. please see your personal health care provider for diagnosis and treatment. We discuss what is meant by Inhalational Alzheimer's. It focuses on the fact that toxins - like mycotoxins and others - come in through the nose to infiltrate the brain. Dr Ackerley describes the first cases she saw with cognitive impairment and the symptoms involved. When did you first notice cognitive symptoms specifically related to mold and biotoxin exposures To help make a diagnosis of mold related cognitive decline - Dr Ackerley uses
    • a persons story (patient history) and his/her symptoms
    • inflammatory labs such as TGFB-1, MMP9, Complement 4a, VEGF
    • Urine Mycotoxin testing
    • volumetric MRI (see previous episode 6 with Dr Cyrus Raji episode)
      • Dr Ackerley uses the NeuroReader Triage brain report
      • she notes thalamus and amygdala enlargement
      • basal ganglia atrophy
    34 min
  • Regenerating a brain...is that really possible? - Ira Pastor with Bioquark Inc
    We are going to take a little different turn this week and perhaps take a look into the future a little bit. We glad to have with us, Ira Pastor, Chief Executive Officer – Bioquark Inc. Ira has over 30 years of experience across multiple sectors of the pharmaceutical industry. Currently, he is also a Board Member of RegenerAge a clinical company focused on expedited translational therapeutic applications of regenerative and rejuvenative healthcare interventions, the Reanima Project (http://www.reanima.tech), and member of the World Economic Forum's Human Enhancement council. Ira's company is applying a technology called combinatory biologics to essentially regrow tissue! check this show out.... Learn more about Ira and his work at BioQuark here
    22 min
  • Gaining Muscle (& Brain) While Losing Weight with Age - Sarcopenic Obesity & Optimal Body Composition

    According to Dr Gabrielle Lyon losing muscle is tantamount to losing brain tissue which is one of the core processes that occurs in Alzheimer's.

    Dr. Gabrielle Lyon is a Functional medicine physician focusing on Muscle-Centric Medicine. She leverages evidence-based medicine with emerging cutting-edge science to restore metabolism, balance hormones and optimize body composition.

    Prior to her foray into medicine, Dr. Lyon was a national semifinalist in Fitness America, and a professional fitness model. Dr Lyon currently works as a practicing physician in New York City. She recently co-authored a chapter in a textbook, the Chapter is entitled "Metabolic Interventions for Sarcopenic Obesity."

    What is sarcopenia? Sarcopenia is age-associated loss of muscle mass and function. When sarcopenia AND obesity are both going on in someone they compound each other. Dr Lyon maintains that there are signs of muscle loss long before actual sarcopenia sets in. Interestingly, obesity is somewhat analogous to aging in that both are low grade inflammatory/catabolic/breakdown states where healing becomes more difficult. Dr Lyon's Ideal Body Weights -Women 15-20% body fat -Men 12-15% How does this get diagnosed or assessed? DEXA scan Gait Speed
    • time yourself to see how long it takes you walk 4, 5, or 10 meters
    • repeat this twice (walking at a comfortable pace for you)
    • an average speed of
    BIA (what are the magic numbers on BIA) Hormone Lab Patters Are Often as Follows
    • LOW: estrogen, total testosterone, SHBG, DHEA, Free thyroxine 3, growth hormone, Insulin-Like Growth Factor 1,
    • INCREASED: prolactin, cortisol, Free thyroxine 4, reverse thyroxine 3, leptin and insulin resistance.
    • Secondary hyperparathyroidism sometimes because of low vitamin D levels
    When Leptin is higher than 10 Dr Lyon notices that people respond well to time restricted eating 2-3 times per week. If higher than 30 she likes them do 24-hour fast once a week (can drink water and coffee, under medical supervision of course). Women's muscle changes as they age. Muscle changes to Type 2 fibers, bulky and strong, and then begins to atrophy. Many aging women tend to lose muscle mass as they age. Dr Lyon notes that many women have under performing (low) thyroid. Thyroid, among other hormones, are important for muscle building, tendon tissue homeostasis (eg alot of musculoskeletal type injury). Dr Lyon goes into detail on where the RDA's recommendations for protein were derived from and how and why she disagrees and other noted experts with them. Dr Lyon suggests a protein intake of 1.5grams per kg of body weight for optimal muscle in aging. This is nearly DOUBLE than the RDA recommendation. The reason for this is to activate a muscle/protein building pathway (ie the "insulin mTOR-metabolic pathway") in the body that will not activate without this. The protein should be distributed over the course of a day (eg 3 times per day) with the right amount and enough of it. At least 30 grams with each of your 3 meals would be the minimum to engage the muscle building pathway. These should typically be spaced about 4 hours away from each other. 90 grams might be the lowest someone would go in order to engage the MTOR-based muscle building pathway. With age reduction of protein absorption, increased splanchnic extraction gives rise to needing to intake higher amounts of protein. 2.5grams of leucine equates to about 4-5 grams of something protein in something like chicken or beef or fortified amino acids powders. mimize carbohydrates to 30-45 grams with meals to reduce your insulin response as carbohydrates are made during your body's breaking down protein. Aging men with healthy kidneys may consider getting up to 40-50 grams up to three times per day. Leucine helps generate Glutamine and Arginine and other elements related to the immune system, blood pressure regulation, and other critical functions Rice/Pea protein are often fortified to have good numbers of branched chain amino acids (leucine importantly included among them). Dr Lyon Exercise Fundamentals Upper Body Resistance -Bench press -Push ups -Pull ups or rowing maching Lower Body Resistance -Squat -Deadlifts General Cardioaerobic -1-2 days per week of 12-20 minutes of interval sprints, rowing or skiing Note: Dr Lyon's approach represents one important approach to muscle synthesis in aging. There are other formidable opinions on the impact of amino acids, high protein diets and aging that were not covered in this episode.
    56 min

About Evolving Past Alzheimer's

From the publisher's feed

We are absolutely convinced that Alzheimer's and other brain diseases are generally treatable and reversible. Early translational evidence supports this belief. The Evolving Past Alzheimer's podcast…

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  2. Number 2: Our Brains Need Meditation - Here's Why with Hemal Patel PhD
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  3. Number 3: The End of Alzheimer's with Dr. Dale Bredesen
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