In this episode of Exploration Science, CEO and Co-founder of Numaferm, Dr. Christian Schwarz, and peptide manufacturing expert, Dr. Alain Scarso, discuss the peptide therapeutics market and dive into the technology of Numaswitch – a transformative biochemical platform to produce peptides, pepteins, and proteins.

In this episode of Exploration Science, Pepticom co-founders, Dr. Immanuel Lerner and Dr. Amit Michaeli, discuss the advantage of employing biocomputational AI software to optimize peptide drug discovery, reduce development risks, and accelerate time to market.

In this episode of ExplorationScience, Dr. Jonathan Steckbeck, the founder and CEO of Peptilogics, discusses the company's approach to peptide drug discovery. Tune into this episode to learn how partnering biology with machine learning is guiding the intelligent navigation of peptide chemical space to develop next-generation therapeutics.

In this episode of Exploration Science, Dr. David Shoultz,

In this episode of Exploration Science, Drs. Ronald Frank (AIMS Scientific Products GmbH) and

Watch on YouTube: https://youtu.be/MBJFIygXDRg

Correction: The founding of AIMS company was in 1998, not 1989.

See the links and references below for some examples of SPOT applications:

AIMS Scientific Products http://www.aims-scientific-products.de/index.php

CEM MultiPep: https://cem.com/multipep2

Clemens Schulte, Vladimir Khayenko, Amit Jean Gupta, Hans Michael Maric. Low-cost

 Melder FTI, Lindemann P, Welle A, Trouillet V, Heißler S, Nazaré M, Selbach M. Compound

 Mohammed El-Mowafy, Ursula Bilitewski. Identification of possible Ser/Thr/Tyr

 Moreno-Yruela, C., Bæk, M., Vrsanova, AE. et al. Hydroxamic acid-modified peptide

 Meyer et al., Mutations in Disordered Regions Can Cause Disease by Creating Dileucine

Rebollo, A., Fliedel, L., Tuffery, P., PEPscan: A Broad-Spectrum Approach for the

Rosie M. Jarrald, Aw W. Liang Alvin, Andrea E. Rawlings, Masayoshi Tanaka, Mina Okochi,

In this episode of Exploration Science Dr. Michael Mina, the Chief Scientific Officer of eMed, discusses immunology and the changing landscape of medicine as technology transforms our options for testing and treatment.

https://www.emed.com/?hsLang=en

In this episode of Exploration Science, Professor Jennifer Heemstra discusses the biomolecular diversity of peptide nucleic acids, the challenges of our current scientific reward structure, and the opportunity to grow through failure.

Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer: https://pubs.acs.org/doi/10.1021/jacs.9b09146

Mentor First Resources: https://mentorfirst.org/

In this episode of Exploration Science, Drs. Gemma Mudd and Kevin McDonnell of Bicycle Therapeutics discuss the Bicycle peptide platform and dive into some of the properties of bicycles that enable the generation of molecules with high affinity, selectivity, and tunable pharmacology.

Links:

https://www.bicycletherapeutics.com/

Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides DOI: 10.1021/acs.bioconjchem.2c00288

Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors

DOI: 10.1158/0008-5472.CAN-18-0238

Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology

DOI: 10.1021/acs.jmedchem.2c00505

In this episode of Exploration Science, Professors César de la Fuente from the University of Pennsylvania and Fabien Plisson from CINVESTAV discuss their pursuit of antimicrobial agents and the utility of AI/ML for peptide discovery.

Links:

Juan CarlosGuido-Patiñoa and FabienPlisson. Profiling hymenopteran venom toxins: Protein families, structural landscape, biological activities, and pharmacological benefits. Toxicon: 10, 14 (2022), 100119. https://doi.org/10.1016/j.toxcx.2022.100119

https://delafuentelab.seas.upenn.edu/research/