This paper explores the potential of cryo-electron ptychography as a novel method for imaging proteins at sub-nanometer resolutions. Traditional cryo-transmission electron microscopy (cryo-EM) faces limitations in resolving smaller proteins due to limited image contrast. However, cryo-electron ptychography, using a coherent diffractive imaging technique with 4D scanning transmission electron microscopy (4D-STEM), has shown promising results in achieving high resolutions.

https://www.biorxiv.org/content/10.1101/2024.02.12.579607v1

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