Understanding how and why arteries age has baffled doctors for years, but a recent study may have the answers we’ve been looking for. Dr. Vienna Brunt, a post-doctorate fellow in the Department of Integrated Physiology of Aging Lab at the University of Colorado in Boulder, walks us through her study published in the journal Hypertension exploring how a compound produced in the gut called “trimethylamine N-oxide” can harm the endothelial lining of our arteries and increase the risk of heart disease with aging.