From NeuroDrugs #2 - streamed live July 15, 2020.

Catch the full conversation here: https://youtu.be/X8_fSqM7AZI 

We're 4 Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis. 

In this clip we review the classic publication that began the 'wanting/liking' dichotomy that researchers are still investigating to this day. Titled "The neural basis of drug craving: An incentive-sensitization theory of addiction", Terry E. Robinson & Kent C. Berridge present a bio - psychological theory of drug addiction, the ‘Incentive-Sensitization Theory’.

The theory addresses three fundamental questions. 

1) why do addicts crave drugs? 

2) why does drug craving persist even after long periods of abstinence? 

3) Whether 'wanting' drugs (drug craving) is attributable to ‘liking’ drugs (to the subjective pleasurable effects of drugs)? Or possibly due to external components altogether. 

The incentive-sensitization theory of addiction posits the following.

1. Addictive drugs enhance dopamine transmission in brain reward regions

2. A major psychological function of this neural system is to attribute ‘incentive salience’ to the perception and mental representation of events associated with activation of the system (drug associated cues and stimuli). 

3. In some individuals the repeated use of addictive drugs produces adaptations in this system, rendering it increasingly and perhaps permanently, hypersensitive (‘sensitized’) to drugs and drug-associated stimuli. This is ultimately a learning & memory based effect. 

open access articles: https://www.sciencedirect.com/science/article/abs/pii/016501739390013P 

& https://www.sciencedirect.com/science/article/pii/S2352154617301948) 

Join us for live stream journal club style conversations & contribute to the discussion at NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube. Stay tuned and subscribe for more content, and to stay up to date with the latest in neuroscience / general science news

A Production of First-Person Science

subscribe @ www.youtube.com/firstpersonsciencepodcast

#psilocybin #ego #Psychotherapy #Psychedelics #synapse #glutamate #neuroscience We're Live at 8pm EDT to discuss new research investigating how psilocybin dissolves the ego and how biology can improve artificial synapses and Artifical intelligence. NeuroBeer Live Stream by the First-Person Science Crew: Monday's 8pm EST

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Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered.

Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves.

A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication.

Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1

A production of First-Person Science

subscribe @ www.youtube.com/firstpersonsciencepodcast

#addiction #neuroscience #dopamine #wanting #liking #NeuroDrugs #live

We're live tonight at 9pm to chat about individual differences in addiction! Why do some people get addicted while others don't? Why is it easier for some to quit while addicted while others struggle more? Why are some more vulnerable to craving and relapse than others? And what does learning and memory have to do with any of this?

Today's paper is entitled "Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction" 

Open access article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635343/ 

We're 4 Canadian neuroscientists reviewing the latest news, events and scholarly publications from neuroscience in our weekly NeuroBeer live stream!

Join us for virtual journal club-esque conversations, & contribute to the discussion with comments, suggestions, recommendations and beyond! We hold NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube. Stay tuned and subscribe for more content, and to stay up to date with the latest in neuroscience news

Leave a comment to join the conversation and guide the discussion!

Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science.

Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. 

If you enjoy this content please consider subscribing to our YT channel www.youtube.com/firstpersonsciencepodcast - It makes a world of difference in our quest to make neuroscience accessible and correct/stop the spread of science misinformation!

Join us for virtual journal club-esque conversations, & contribute to the discussion with comments, suggestions, recommendations and beyond! We hold NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube. Stay tuned and subscribe for more content, and to stay up to date with the latest in neuroscience news

Intro music by Navigator Black & The Indighost

#addiction #opiates #memory #learning #reward #dopamine #neuroscience #NeuroBeer link to article: https://www.annualreviews.org/doi/abs/10.1146/annurev-psych-010418-103337 Leave a comment to join the conversation and guide the discussion! Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 Intro music by Navigator Black & The Indighost

#addiction #theories #neuroscience Leave a comment to join the conversation and guide the discussion! Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 Intro music by Navigator Black & The Indighost

#History #opiates #harms #benefits #neurobiology #neuroscience #addiction #science #live #livestream #askscience #medicine #addictionscience We're Live at 9pm to review the history of opiates, their potential harms & benefits of in the context of addiction and medical use, and the neuroscience of opiate addiction! Join the DrugNerds discord server: https://discord.gg/pQBY9jj for comments to display live onscreen and to contribute to the conversation live! NeuroBeer Live Stream by the First-Person Science Crew: Monday's 8pm EDT, Wednesday's 9pm EDT

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Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 Intro music by Navigator Black & The Indighost

In this video we discuss the root causes and some extreme examples of fake news in science. How can we work together to stop this ongoing trend of misinformation and anti-science activism?

The structure of the information, the literacy of the consumer, and the accessibility of the material determine how the information is used, by whom, and the influence it ultimately has on a group, community, or society. However, there is perhaps a more dangerous perspective; that the way information is presented has the potential to misrepresent and distort, with important parallels and implication for engagement with research, media, and public policy in public forums, such as twitter and facebook. In some cases, if a series of google searches reveals informative (yet incomplete) summaries of evidence that misrepresent the rigor and strength of the component studies, it has the potential to change practice in a way that may be deleterious to future science, medicine, & public discussion.

Special Thanks to GradCast for hosting this episode and supporting the fight again Science Misinformation! Check out the full episode on their website: www.gradcast.ca or their youtube channel: https://www.youtube.com/channel/UCQOc6TUPpSADZW7_hanKHEQ

Produced by Roger Hudson, PhDc

Directed by Dr. Mina Nashed, PhD

Visual Effects by Dr. Stephen Daniels, PhD

Audio Mixing by Dr. Paul Sheppard, PhD

Digital Marketing by Bryan Jenkins, PhDc

Theme music: MegaDisko by Navigator Black & the Indighost

What is the value of science communication if there is distrust in the accuracy, completeness, or truthfulness of the information presented? Media will often use strategies of selectivity to present a narrative that is most appealing to their financial interests (cannabis causes schizophrenia? Find out tonight at 6), but do not work to benefit the public whatsoever. In fact, these techniques to conceal some information, while bringing other info to light actively works against the interest of the public, and instead dissuades critical thinking and further fact checking, ultimately creating confusion and causing more harm than good. The structure of the information, the literacy of the consumer, and the accessibility of the material determine how the information is used, by whom, and the influence it ultimately has on a group, community, or society.

We planned to give you Dr. Christopher Norris's work on the positive vs negative effects of cannabis intoxication (euphoria vs anxiety) and the associated biomarkers, but we got into a discussion on the problems with pop-science & science communication - from scientist communication fails, to public ignorance, to flat out fake news portrayed by media. Stay tuned for this exciting cannabis-related episode coming soon!

Produced by Roger Hudson, PhDc

Directed by Dr. Mina Nashed, PhD

Visual Effects by Dr. Stephen Daniels, PhD

Audio Mixing by Dr. Paul Sheppard, PhD

Digital Marketing by Bryan Jenkins, PhDc

Theme music: MegaDisko by Navigator Black & the Indighost

Education about the health harms of tobacco have driven nicotine use down across all age groups for several decades. However, since 2016 the rate of adolescent and teenage nicotine use has nearly tripled, most commonly in the form of e-vapes (juuling). Although nicotine vapour May potentially be less harmful to overall health than tobacco smoke, a wealth of research identifies that nicotine exposure during adolescence or teenage years dramatically increases the risk for leader mental health disorders including depression and anxiety, independent of whether the individual continues to use nicotine products later into adulthood. These largely overlooked mental health consequences to later life, as well as potential negative outcomes for multiple generations on offspring of the nicotine user amount to largely unknown consequences of adolescent nicotine exposure.

In this episode, Roger Hudson joins asked to speak about his recent manuscript exploring the presence of persistent mood and anxiety disorders following nicotine exposure throat adolescence, published in the Journal Addiction Biology. Manuscript Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12891

Produced by Roger Hudson, PhDc

Directed by Dr. Mina Nashed, PhD

Visual Effects by Dr. Stephen Daniels, PhD

Audio Mixing by Dr. Paul Sheppard, PhD

Digital Marketing by Bryan Jenkins, PhDc

Theme music: MegaDisko by Navigator Black & the Indighost

Many claims have been made regarding the relation between cannabis use and psychiatric disorders, such as schizophrenia. The idea that frequent use of potent cannabis can elicit detrimental effects on cognition, learning & memory, & executive function is generally accepted. But how does THC, the main psychoactive compound in cannabis, produce changes in brain function that ultimately manifest as symptoms like psychosis that resemble that chief features of schizophrenia? And which brain regions & connections are primarily involved in mediating these effects?

In this episode, Bryan Jenkins - Neuroscience PhD Candidate from the University of Guelph - joins us to discuss how a single exposure to vaporized THC can elicit long-term changes in brain waves (oscillatory activity) such as delta, theta, & gamma waves that strikingly resemble the changes observed in patients with schizophrenia. This work has vast implications for our understanding of recreational cannabis use & cannabis use disorder, & how they relate to brain changes that underlie the onset of schizophrenia and related disorders. These results may also inform on public health regarding the increased rates of vaping seen in youth and adolescents in recent years.

Manuscript: Published in the Canadian Journal of Addiction: https://journals.lww.com/cja/Abstract/2019/09000/Extended_Attenuation_of_Corticostriatal_Power_and.9.aspx

Produced by Roger Hudson, PhDc

Directed by Dr. Mina Nashed, PhD

Visual Effects by Dr. Stephen Daniels, PhD

Audio Mixing by Dr. Paul Sheppard, PhD

Digital Marketing by Bryan Jenkins, PhDc

Theme music: MegaDisko by Navigator Black & the Indighost