Cate Hall is the CEO of Astera. She’s a former Supreme Court attorney and the ex-No. 1 female poker player in the world. Before joining Astera, she co-founded and served as COO and later co-CEO of Alvea, a pandemic medicine company that set the record for the fastest startup to take a drug candidate to Phase I clinical trial. She received a BS in biochemistry and BA in philosophy from the University of Arizona, and a law degree from Yale Law School.

About Foresight Institute

Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.

Get Involved with Foresight:

• Apply to our virtual technical seminars 
• Join our in-person events and workshops 
• Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!

Follow Us: Twitter | Facebook | LinkedIn

Hosted on Acast. See acast.com/privacy for more information.

Sam Rodriques is an inventor and entrepreneur. In 2023, he launched FutureHouse, a new research lab in San Francisco focused on building an AI Scientist. He previously ran the Applied Biotechnology Lab at the Francis Crick Institute. Before that, he did his PhD at MIT. Sam also proposed the Focused Research Organization model, which is now being used by a number of philanthropic funders and governments to facilitate scientific moonshots.

About Foresight Institute

Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.

Get Involved with Foresight:

• Apply to our virtual technical seminars 
• Join our in-person events and workshops 
• Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!

Follow Us: Twitter | Facebook | LinkedIn

Hosted on Acast. See acast.com/privacy for more information.

Tom Kalil is the CEO of Renaissance Philanthropy. Tom served in the White House for two presidents (Obama and Clinton) and in collaboration with his team worked with the Senate to give every federal agency the authority to support incentive prizes for up to $50 million. Tom also designed and launched dozens of White House science and technology initiatives, including the $40 billion National Nanotechnology Initiative, announced by President Clinton; The BRAIN Initiative, announced by President Obama; The Next Generation Internet initiative, announced by President Clinton and Vice President Gore; and initiatives in advanced materials, robotics, smallsats, data science, and EdTech.

About Foresight Institute

Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.

Allison Duettmann

The President and CEO of Foresight Institute, Allison Duettmann directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, alongside Fellowships, Prizes, and Tech Trees. She has also been pivotal in co-initiating the Longevity Prize, pioneering initiatives like Existentialhope.com, and contributing to notable works like "Superintelligence: Coordination & Strategy" and "Gaming the Future".

Get Involved with Foresight:

• Apply to our virtual technical seminars 
• Join our in-person events and workshops 
• Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!

Follow Us: Twitter | Facebook | LinkedIn

Note: Explore every word spoken on this podcast through Fathom.fm, an innovative podcast search engine.

Hosted on Acast. See acast.com/privacy for more information.

In this episode of the Existential Hope Podcast, cognitive psychologist and bestselling author Steven Pinker explores why, despite massive gains in human progress, many people remain pessimistic about the future—and why that matters for shaping what comes next.

Steven argues that while progress isn’t automatic, it is real. By tracking long-term trends in violence, poverty, democracy, and innovation, we can see how human effort—driven by reason, science, and cooperation—has repeatedly pushed civilization forward. Yet, media narratives and cognitive biases often make us blind to these achievements, reinforcing a sense of stagnation or decline.

In this conversation, we explore:

• The hidden progress shaping our world today—from rising literacy rates to declining poverty, and why these trends rarely make the news.
• Why pessimism can be self-defeating—and how a more accurate understanding of history can help us build a better future.
• The role of AI, biotech, and clean energy—and why they might unlock transformative improvements, if used wisely.
• How to communicate ideas that inspire hope—including Steven’s advice on cutting through jargon and tribalism to make ideas stick.

If you’ve ever wondered whether humanity is on the right track—or how to ensure we stay on it—this episode is for you. Listen now to hear how we can move from existential dread to existential hope. 🚀

Full transcript, list of resources, and art piece: https://www.existentialhope.com/podcasts

Existential Hope was created to collect positive and possible scenarios for the future so that we can have more people commit to creating a brighter future, and to begin mapping out the main developments and challenges that need to be navigated to reach it. Existential Hope is a Foresight Institute project.

Hosted by Allison Duettmann and Beatrice Erkers

Follow Us: Twitter | Facebook | LinkedIn | Existential Hope Instagram

Explore every word spoken on this podcast through Fathom.fm.

Hosted on Acast. See acast.com/privacy for more information.

Jennifer Garrison, PhD, is Co-Founder and Director of the Global Consortium for Reproductive Longevity and Equality (GCRLE) and an Assistant Professor at the Buck Institute for Research on Aging. She also holds appointments in the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco (UCSF) and the Leonard Davis School of Gerontology at the University of Southern California (USC). She is a passionate advocate for women’s health and is pioneering a new movement to advance science that is focused on female reproductive aging. Her lab studies the role of mind-body communication in systemic aging, and how changes in the conversation between the ovary and brain during aging may lead to the onset of reproductive decline in females.

About Foresight Institute

Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.

Allison Duettmann

The President and CEO of Foresight Institute, Allison Duettmann directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, alongside Fellowships, Prizes, and Tech Trees. She has also been pivotal in co-initiating the Longevity Prize, pioneering initiatives like Existentialhope.com, and contributing to notable works like "Superintelligence: Coordination & Strategy" and "Gaming the Future".

Get Involved with Foresight:

• Apply to our virtual technical seminars 
• Join our in-person events and workshops 
• Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!

Follow Us: Twitter | Facebook | LinkedIn

Note: Explore every word spoken on this podcast through Fathom.fm, an innovative podcast search engine.

Hosted on Acast. See acast.com/privacy for more information.

"We’ve saved the world so many times throughout history. Now we just have to do it again."

What if speculative fiction could do more than entertain—what if it could reshape how we think about governance, technology, and societal progress? In this episode of the Existential Hope Podcast, historian and sci-fi author Ada Palmer discusses how we can harness lessons from both history and fiction to reimagine what’s possible for humanity.

Ada argues that one of the most critical advantages we have over past generations is our ability to envision a future radically different from our present. Unlike Renaissance thinkers limited by their own history, today’s societies can draw from an endless array of speculative worlds—both utopian and dystopian—to expand the horizons of what we dare to demand.

In this wide-ranging conversation, Ada digs into everything from concrete ideas for how to govern in a more pluralistic, adaptable world, to the importance of storytelling in addressing existential risks, exploring:

• Why pluralism might be the antidote to centralized, one-size-fits-all governance and how speculative fiction shows us ways to make it work.
• How past and present technological advancements—like eradicating malaria—can inspire hope for tackling today’s most urgent challenges.
• What makes despair the ultimate barrier to progress, and how celebrating successes can keep us moving forward.

Full transcript, list of resources, and art piece: https://www.existentialhope.com/podcasts

Existential Hope was created to collect positive and possible scenarios for the future so that we can have more people commit to creating a brighter future, and to begin mapping out the main developments and challenges that need to be navigated to reach it. Existential Hope is a Foresight Institute project.

Hosted by Allison Duettmann and Beatrice Erkers

Follow Us: Twitter | Facebook | LinkedIn | Existential Hope Instagram

Explore every word spoken on this podcast through Fathom.fm.

Hosted on Acast. See acast.com/privacy for more information.

Abhishek Singh is a Ph.D. student at MIT Media Lab. His research interests include collective intelligence, self-organization, and decentralized machine learning. The central question guiding his research is --- how can we (algorithmically) engineer adaptive networks to build anti-fragile systems? He has co-authored multiple papers and built systems in machine learning, data privacy, and distributed computing. Before joining MIT, Abhishek worked with Cisco for 2 years where he did research in AutoML and Machine Learning for systems.

An Abstract

The remarkable scaling of AI models has unlocked unprecedented capabilities in text and image generation, raising the question: why hasn't healthcare seen similar breakthroughs? While healthcare AI holds immense promise, progress has been stymied by fragmented data trapped in institutional silos. Traditional centralized approaches fall short in this domain, where privacy concerns and regulatory requirements prevent data consolidation. This talk introduces a framework for decentralized machine learning and discusses algorithms for enabling self-organization among participants with diverse resources and capabilities.

About Foresight Institute

Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.

Allison Duettmann

The President and CEO of Foresight Institute, Allison Duettmann directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, alongside Fellowships, Prizes, and Tech Trees. She has also been pivotal in co-initiating the Longevity Prize, pioneering initiatives like Existentialhope.com, and contributing to notable works like "Superintelligence: Coordination & Strategy" and "Gaming the Future".

Get Involved with Foresight:

• Apply to our virtual technical seminars 
• Join our in-person events and workshops 
• Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!

Follow Us: Twitter | Facebook | LinkedIn

Note: Explore every word spoken on this podcast through Fathom.fm, an innovative podcast search engine.

Hosted on Acast. See acast.com/privacy for more information.

Zach Weinersmith is the cartoonist behind the popular geek webcomic, Saturday Morning Breakfast Cereal. He writes popular science books with his wife Kelly, including the recent Hugo award-winning A City on Mars. His work has been featured by The Economist, The Wall Street Journal, Slate, Forbes, Science Friday, Foreign Policy, PBS, Boingboing, the Freakonomics Blog, the RadioLab blog, Entertainment Weekly, Mother Jones, CNN, Discovery Magazine, Nautilus and more.

Key Highlights

• The future of space governance is explored, focusing on rocketry, space settlements, international law, and challenges like closed-loop ecology and human reproduction.
• Zubrin's "The Case for Mars" is criticized for optimism, colonialist perspectives, and assumptions about sustainable environments on Mars.
• Physiological risks of space travel, including radiation, reduced gravity, and the lack of reproduction data, are highlighted.
• Lessons from Biosphere 2 and doubts about the economic and legal viability of Mars colonization are discussed.
• Debates cover the Moon Treaty, anti-space settlement arguments, and testing reproduction in partial gravity.

About Foresight Institute

Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.

Allison Duettmann

The President and CEO of Foresight Institute, Allison Duettmann directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs.

Get Involved:

• Apply to our virtual technical seminars 
• Join our in-person events and workshops 
• Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!

Follow Us: Twitter | Facebook | LinkedIn

Note: Explore every word spoken on this podcast through Fathom.fm, an innovative podcast search engine.

Hosted on Acast. See acast.com/privacy for more information.

Jason Crawford is the founder of The Roots of Progress, a nonprofit dedicated to establishing a new philosophy of progress for the 21st century. He writes and speaks about the history and philosophy of progress, especially in technology and industry. 

Key Highlights

About Foresight Institute

Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.

Allison Duettmann

The President and CEO of Foresight Institute, Allison Duettmann directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, alongside Fellowships, Prizes, and Tech Trees. She has also been pivotal in co-initiating the Longevity Prize, pioneering initiatives like Existentialhope.com, and contributing to notable works like "Superintelligence: Coordination & Strategy" and "Gaming the Future".

Get Involved with Foresight:

• Apply to our virtual technical seminars 
• Join our in-person events and workshops 
• Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!

Follow Us: Twitter | Facebook | LinkedIn

Note: Explore every word spoken on this podcast through Fathom.fm, an innovative podcast search engine.

Hosted on Acast. See acast.com/privacy for more information.

Beatrice Erkers and Allison Duettmann

What if we could reimagine the future from a place of hope instead of fear?

In this special episode of the Existential Hope Podcast, Allison Duettmann and Beatrice Erkers turn the tables and interview each other instead of a guest, sharing insights into their journeys, hopes, and visions for humanity. Together, they explore big concepts like moral circle expansion, how neurotech could deepen empathy (even with animals!), and why worldbuilding in 2045 can help us envision and create better futures today. Prepare for the new year by diving into strategies for building a future worth striving for.

Full transcript, list of resources, and art piece: https://www.existentialhope.com/podcasts

Existential Hope was created to collect positive and possible scenarios for the future so that we can have more people commit to creating a brighter future, and to begin mapping out the main developments and challenges that need to be navigated to reach it. Existential Hope is a Foresight Institute project.

Hosted by Allison Duettmann and Beatrice Erkers

Follow Us: Twitter | Facebook | LinkedIn | Existential Hope Instagram

Explore every word spoken on this podcast through Fathom.fm.

Hosted on Acast. See acast.com/privacy for more information.