Is AI really that powerful? Short answer: yes. Long answer: watch this.

In this clip, Dev explains how spotting AI’s real superpower - pattern recognition - led to the creation of NPLAN, an AI company transforming how mega-projects get delivered.

What You’ll Learn 👇

1. Why most people underestimated AI back in 2016

2. The real superpower of AI: pattern recognition at scale

3. How “unlimited experience” could change entire industries

4. The insight that sparked the creation of NPLAN

👉 If you enjoyed this, check out the full episode for the complete conversation.

⭐ Listeners Suggestion - Software of the Week: https://www.granola.ai/

👍 Why subscribe?If you sketch business ideas on napkins, obsess over product‑market fit, or dream of disrupting incumbents with AI, this channel is for you.

🔔 Tap the bell so YouTube tells you the moment new episodes drop 🔔

#constructionai #devamratia #nplan #foundersandbuilders

In this clip, Dev Amratia, co-founder and CEO of NPLAN, breaks down why traditional pricing models don’t capture true value and shares his vision for a future built on ‘bounty pricing.’

👉 If you enjoyed this, check out the full episode for the complete conversation.

⭐ Listeners Suggestion - Software of the Week: https://www.granola.ai/

👍 Why subscribe?If you sketch business ideas on napkins, obsess over product‑market fit, or dream of disrupting incumbents with AI, this channel is for you.

🔔 Tap the bell so YouTube tells you the moment new episodes drop 🔔

#constructionai #devamratia #nplan #foundersandbuilders

“If you build billion-dollar projects on gut feel, you’ll burn billions.”

In this episode, Dev Amratia, co-founder of Nplan - explains how AI trained on hundreds of thousands of construction schedules can finally fix why mega-projects run late and over budget.

From Shell and Crossrail to grids, hospitals, and railways, Dev breaks down the human biases that wreck timelines and how Nplan’s AI (yes, the assistant’s called Barry) helps teams decide faster, de-risk earlier, and unlock capital for critical infrastructure.

What You Will Learn! 👇

1. ​ Why humans are bad at forecasting (availability, optimism, salience) and how that snowballs into 40–100% delays
2. ​ The Shell story: when uncertainty ruins billion-dollar decisions
3. ​ Nplan’s origin: 200+ interviews, The Mom Test, and the data everyone said “you’ll never get”
4. ​. Pattern recognition at scale: what AI actually does for construction
5. ​ Replacing the services layer: the painful product decision that unlocked scale
6. ​ Pricing the unpriceable: toward “bounty” pricing tied to value created
7. ​ Public infrastructure focus: why Nplan chose the hardest buyers - and won
8. ​ The 10-year view: de-facto risk standard for the built world + more bankable projects

EPISODE CHAPTERS:

(00:00) Introduction

(10:01) Seeking Allies and Valuable Insights

(13:28) Caring and Valuable Insights in Business

(22:28) Reducing Uncertainty to Drive Decision-Making

(30:50) Building a Successful Software Product

(42:50) Innovative Pricing Models for Consulting

(48:56) Legacy of Inspiration and Industry

⭐ Listeners Suggestion - Software of the Week: https://www.granola.ai/

👍 Why subscribe?If you sketch business ideas on napkins, obsess over product‑market fit, or dream of disrupting incumbents with AI, this channel is for you.

🔔 Tap the bell so YouTube tells you the moment new episodes drop 🔔

#constructionai #devamratia #nplan #foundersandbuilders

In this clip, Stephen Whitworth, co-founder of incident.io shares the two biggest decisions that shaped the company’s success - and the hardest challenge every founder eventually faces.

He talks about building a revenue-focused product team, ruthlessly dogfooding their own platform, and why hiring remains the most irreducibly complex part of scaling a startup.

👉 If you enjoyed this, check out the full episode for the complete conversation.

⭐ Listener Suggestion – Software of the Week: https://elevenlabs.io/

👤 About StephenStephen Whitworth is the co-founder and CEO of incident.io, a platform that helps teams manage incidents with speed and clarity.

A former engineer at Monzo, he’s passionate about customer-centric product building, scaling teams, and solving complex problems through culture and technology.

👍 Why subscribe?

If you sketch business ideas on napkins, obsess over product-market fit, or dream of disrupting incumbents with AI, this channel is for you.

🔔 Tap the bell so YouTube tells you the moment new episodes drop 🔔

#foundersandbuilders #incidentio #startupgrowth

Stephen Whitworth is the co-founder & CEO of Incident, the company building the emergency response layer for the internet. Before Incident, he saw the cracks firsthand at Monzo - the outages, the midnight firefighting, the broken playbooks.

Now, backed by investors like Index, Insight Partners, and Point Nine with $96M raised, Stephen and his team are re-wiring how the world responds when the systems we all rely on suddenly fail.

🔍 What You’ll Learn In This Episode:

- Why the biggest opportunities often hide inside the biggest problems.

- How to validate a high-stakes startup idea when there’s no playbook.

- The mindset shift from firefighting problems to designing solutions.

- Lessons from raising $96M: what actually matters to top-tier investors.

- Why founders should obsess less about “being ready” and more about moving fast.

EPISODE CHAPTERS:

(00:01) Building a $10 Billion Company

(11:54) Early Days of Starting a Business

(20:49) Customer Success and Product Growth

(29:08) Customer-Centric Product Development Success

(36:51) Leveraging Internal Product Use for Growth

(43:49) Navigating Board Involvement and Decision-Making

(48:39) Managing Growth and Investment Strategy

(54:21) Venture Capital and International Expansion

(01:00:00) Building a Global Business From Scratch

(01:07:15) Motivation in Building Large Companies

⭐ Listeners Suggestion - Software of the Week: https://elevenlabs.io/

👍 Why subscribe?If you sketch business ideas on napkins, obsess over product‑market fit, or dream of disrupting incumbents with AI, this channel is for you.

🔔 Tap the bell so YouTube tells you the moment new episodes drop 🔔

#stephenwhitworth #incidentio #foundersandbuilders

In this clip, Pinstripe Chris reflects on creativity, discipline, and why life is ultimately about experiences and memories, not just work. He talks about the balance between Rick Rubin’s go-with-the-flow approach and Steven Pressfield’s disciplined mindset, and how both shape his outlook on art and life.👉 If you enjoyed this, check out the full episode for the complete conversation.

⭐ Listeners Suggestion - Software of the Week: https://lovable.dev/

👤 About Chris“Pinstripe Chris” is an automotive artist who’s built a global brand creating one-off masterpieces for brands like Porsche. From collision shops to California, he’s proof that betting on yourself can change everything.

👍 Why subscribe? If you sketch business ideas on napkins, obsess over product‑market fit, or dream of disrupting incumbents with AI, this channel is for you.

🔔 Tap the bell so YouTube tells you the moment new episodes drop 🔔

#foundersandbuilders #pinstripechris #automotiveart

“I’ve never had a problem betting on me.” Chris Dunlop (Pinstripe Chris) Chris built a global brand painting one-off masterpieces for companies like Porsche without art school, safety nets, or a plan B.

🔍 What You’ll Learn In This Episode:

- Why the boldest investment you can make is in yourself.

- The hidden process behind Pinstripe Chris’s “overnight success.”

- How to build creative freedom instead of getting stuck chasing paychecks.

- The mindset shift that turns mistakes into signatures.

- Why the “perfect time” to start never comes - and why that’s your advantage.

EPISODE CHAPTERS:

(00:02) From Collision Shops to Masterpieces

(03:29) From Auto Shops to Artistry

(13:09) Finding Success Through Social Media

(22:44) Thriving in Car Culture Industry

(28:02) Embracing Risk and Rejecting Structure

(36:36) The Artistic Journey

(43:30) Navigating Artistic Freedom and Risk

(53:49) Reflecting on Career Satisfaction and Growth

(57:14) Navigating Opportunities and Self-Promotion

(01:02:42) Artistic Process and Social Media Marketing

(01:13:27) Life Lessons Through Artistic Process

(01:18:37) Balancing Creativity and Discipline

⭐ Listeners Suggestion - Software of the Week: https://lovable.dev/

👤 About Chris“Pinstripe Chris” is an automotive artist who’s built a global brand creating one-off masterpieces for brands like Porsche. From collision shops to California, he’s proof that betting on yourself can change everything.

👍 Why subscribe?If you sketch business ideas on napkins, obsess over product‑market fit, or dream of disrupting incumbents with AI, this channel is for you.

🔔 Tap the bell so YouTube tells you the moment new episodes drop 🔔

#foundersandbuilders #pinstripechris #automotiveart

🚀 “Entire software categories are up for grabs.”

Investor Akash Bajwa explains why the next wave of AI‑native startups will rewrite today’s playbooks and how first‑time founders can ride it.

What you’ll learn

• The three‑layer stack (AI chips → models → apps) and the product & data flywheel that lets tiny startups punch above their weight.
• A clear framework for deciding “AI‑native or AI‑assist?” for your startup. Why 2025 feels like a 1994‑style inflection point for builders—and how timing alone can hand newcomers a huge edge.
• Talent‑density tactics: hire “heat‑seeking missiles” and design org charts that scale themselves.
• The coming surge of autonomous agents and micro‑transactions, plus the strange new business models they unlock.
• Five bold 2035 predictions that will reshape product, funding, and daily work.

⏱️ Chapters

0:00 Intro

5:23 What “AI‑native” really means

10:34 Designing lean, taste‑driven teams

20:30 The vertical stack playbook

26:29 Evals as the hidden moat

34:57 Agents 101 and the Model Context Protocol

39:47 Micro‑payments, macro impact

45:22 2035 outlook for founders

56:41 Hiring, culture, and rebellious opinions

1:04:15 Rapid‑fire takeaways

Why subscribe? If you sketch business ideas on napkins, obsess over product‑market fit, or dream of disrupting incumbents with AI, this channel is for you. 🔔 Hit subscribe so Spotify tells you the moment new episodes drop 🔔

Keywords: AI startup, entrepreneur tips, venture capital, SaaS, Earlybird Venture Capital, Akash Bajwa interview, AI‑native products, vertical integration, talent density, autonomous agents, evals, Founders and Builders podcast, build with AI, startup playbook, how to start a tech company, seed fundraising, product strategy, software innovation.#AI #Startups #Entrepreneurship #Software #VentureCapital

💊 90% of drugs fail. Clinical trials take years. And billions are lost every time.

In this episode of Founders & Builders, I sit down with Dr. Olga Kubassova, a mathematician turned biotech investor, and founder of Image Analysis Group — a company using AI-powered imaging biomarkers to reinvent how we measure whether a drug is actually working.

We cover:

🧠 Why clinical trials are broken — and what needs to change

📉 How AI biomarkers let us see disease earlier and treatment faster

⚙️ What makes a billion-dollar drug fail — and how we can spot it sooner

💡 Olga’s journey from math PhD to advising governments and top pharma

🏥 The future of precision medicine and data-driven trials

One of my favorite moments:“If you can see disease earlier and measure treatment faster — that’s the difference between a failed drug and a billion-dollar success.”

This is a conversation about the future of medicine — and how AI is changing everything.

🧬 Most new medicines are billion-dollar bets made in the dark.Charm Therapeutics is changing that — using AI to design drugs that actually work.Laksh Aithani, co-founder and CEO, joins the Founders and Builders podcast to break down how AI is transforming drug discovery — and why Charm raised $50M from Nvidia, General Catalyst, and Khosla Ventures to do it.We talk about:– The wild science behind protein folding– Why most drugs still fail in trials– How Charm slashes R&D timelines using DragonFold– What it really takes to build a biotech company at 27This episode is a window into the future of how medicine gets made.