In the first episode of the Psychological Society of Ireland's (PSI) 2021 Podcast Series we welcome PSI Chartered Member and Professor of Psychology at NUI Galway, Prof. Brian Hughes, and Professor of Biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin, Prof. Luke O'Neill, as they discuss circumstances surrounding the pandemic, vaccine hesitancy and where the nation currently stands in the fight against COVID-19.