From the Spectrum: Finding Superpowers with Autism

Originally released in May 2025, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

Video: https://youtu.be/SjOKEX_KO3A?si=fYsl9tS0sVUAhozL

Dr. Richard Frye, MD, PhD, returns to discuss leucovorin, folate metabolism, and the growing research examining their relationship with autism. Dr. Frye is a child neurologist and autism researcher with extensive work investigating metabolic and physiological differences associated with neurodevelopmental disorders.

We explore why folate is so important to the brain, how folate crosses the blood-brain barrier, cerebral folate deficiency, folate receptor alpha autoantibodies, and the biological mechanisms that led researchers to investigate leucovorin in autism. Dr. Frye also walks through clinical research examining leucovorin and verbal communication, discusses why some individuals may respond differently than others, and explains the connections among folate metabolism, neurotransmitters, methylation, mitochondrial function, and neurodevelopment.

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0:00 Dr. Richard Frye

0:58 Daylight Computer Company

5:17 Chroma Light Devices

8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa)

10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid)

14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase)

17:34 Cerebral Folate deficiency; BH4, Placenta & Womb

23:35 Folate deficiency & Autism

26:21 Clinical Studies & Data

29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!)

34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors

40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration

42:53 Folate Autoantibodies & Maternal Health & Markers

45:30 Studies & Behavioral outcomes; inflammation & thyroid findings

46:58 Neural development; Language connections, white matter tracts & distal connections

48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida

51:08 Preparing for pregnancy

53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness

59:32 Guidance & Support

Originally released in September 2024, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

Video: https://youtu.be/_wsDkv-dkEU?si=uTaUav5v7YfZBsaO

In this episode, I speak with Dr. Richard Frye, MD, PhD, a child neurologist and autism researcher whose work examines the metabolic and physiological systems associated with neurodevelopmental disorders. Dr. Frye received his MD and PhD in Physiology and Biophysics from Georgetown University and has published extensively on autism, mitochondrial function, metabolism, and related areas of medicine.

We explore mitochondria far beyond their familiar description as the “powerhouse of the cell,” including their roles in energy production, metabolism, oxidative stress, immune function, and sensing changes in the environment. Dr. Frye explains mitochondrial dysfunction, the citric acid cycle, the electron transport chain, biomarkers of mitochondrial function, and the complex relationship among mitochondria, inflammation, and cellular health. We also discuss autism, environmental influences, light, photobiomodulation, and emerging research.

Dr, Richard Frye https://drfryemdphd.com

Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter

Neurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3Dihub

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0:00 Dr. Richard Frye

6:13 Intro into mitochondria & energy production, various disease & dysfunction

11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics

16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain

20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine

26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria

30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation

34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression

42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis

45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm)

54:54 Future Research

Originally released in April 2025, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

In this episode, I speak with Dr. Reza Shadmehr of Johns Hopkins University about the cerebellum and one of the brain's most fundamental problems: how do we learn to control our movements accurately? With a background spanning electrical engineering, robotics, biomedical engineering, and neuroscience, Dr. Shadmehr has spent his career investigating the computations that allow the brain to learn, predict, and control movement.

We discuss internal models, motor learning and memory, prediction, sensory feedback, error correction, Purkinje cells, and how the cerebellum helps distinguish the sensory consequences of our own actions from information coming from the outside world. We also explore reward and effort, eye and tongue movements, research with marmosets, sensory processing, and the possible relevance of cerebellar function beyond movement, including cognition and autism. The conversation reveals the cerebellum as much more than a structure for coordination. It is deeply involved in learning what to expect and using those predictions to make behavior accurate.

Shadmehr Lab: http://shadmehrlab.org

Publications: http://shadmehrlab.org/publications

YT Videos (Very Good !): https://www.youtube.com/@shadmehrlab1352

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00:00 Reza Shadmehr

02:26 Daylight Computer Company, use "autism" for $25 discount

06:45 Chroma Light Devices- Lights Designed for Humans, use "autism" for 10% discount

9:54 Reza's journey into Biomedical Engineering & Neuroscience

16:26 Understanding the Cerebellum; 3 primary functions

22:07 Neuronal Communication & Purkinje Cells; Sensory and Interneurons

25:41 Cerebellum, eyes, and Autistic phenotype; Mesencephalon & other connections

28:13 Excitation/Inhibition (E/I) balance; Video examples & Movement deficiencies

29:29 Layers of the Cerebellum

34:08 E/I & Brain function

36:30 Learning & Memory in the Cerebellum

39:54 Dysfunction & Brain Compensation

41:57 Basal Ganglia and Cerebellum

43:48 Internal Calculators & Prediction

49:42 Reward & Movement & Accuracy

52:52 Movement control; Eye movements

55:56 Purkinje Cells & Tongue movements; deceleration

59:47 Understanding Language of the Cerebellum

1:01:58 Future of Cerebellar Technology

Originally released in October 2024, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

In this episode, I speak with Nicole Rincon, PA-C, a board-certified physician assistant at Rossignol Medical Center whose work focuses on pediatric special needs, integrative medicine, and functional medicine. Nicole brings both a clinical and deeply personal perspective to the conversation as the mother of children who experienced developmental regression and were diagnosed with autism.

We discuss autism and regression through a biological and functional medicine lens, including mitochondria, metabolism, gastrointestinal health, inflammation, nutrition, environmental factors, and the potential role of medical comorbidities. Nicole also shares her family's experience and how it ultimately led her from nutritional and wellness medicine into working with autistic children and their families. Throughout the conversation, we explore both established research and emerging or debated areas of investigation in an effort to better understand the biology that may accompany autism beyond its behavioral presentation.

Nicole Rincon https://www.nicolerincon.com/nicole-rincon

Rossignol Medical Center https://rossignolmedicalcenter.com/doctors/nicole-rincon/

TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdf

TACA Talks: https://www.nicolerincon.com/videos

Publications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articles

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00:00 Nicole Rincon

02:07 From Mother & Clinician to Autism Medicine

12:30 Autism Regression; Omegas, Mitochondria & Environmental Factors

21:56 Functional Medicine & Rossignol Medical Center

25:07 Folate, Folate Receptor Antibodies & Methylation

30:36 Mito Dysfunction & Autism Comorbidities

42:22 Challenges with the Medical Paradigm; Maternal Health

48:34 Looking Beyond Vaccines; Environment, Light & Human Biology

53:26 The Functional Medicine Evaluation; Looking Upstream

1:02:00 A Multifactorial Approach to Autism & the Future of Medicine

Originally released in October 2024, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

For today’s episode, New York Times and international bestselling author J.D. Barker joins me to discuss autism, creativity, imagination, and the way he experiences the world. Barker is the author of The Fourth Monkey and Forsaken, has collaborated with James Patterson, and was approached by Bram Stoker’s family to coauthor Dracul using previously unpublished material from Stoker.

Barker shares how autism influences the way he recognizes patterns, constructs stories, visualizes characters, manages multiple projects, and navigates the social world. We discuss masking, intense interests, autistic burnout, and what can happen when autistic traits are understood and cultivated rather than simply treated as deficits. His story offers a fascinating look at the relationship between autism, creativity, structure, and a remarkably successful writing career.

J.D. Barker https://jdbarker.com/books/heavy-are-the-stones/

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0:00 JD Barker

2:49 Early Years of Creativity, Books, & Understanding Autism; Trying to Fit-In; Following Rules, Black and White thinking versus Gray

11:43 Superpowers of Writing as a Reflection, Creativity, & Intelligence of the Inner World

15:00 Superpowers of Autism by Creating Catalogs: Patterns, Visual & Thinking in Pictures, & Creating Characters

20:42 Balancing Life with Autism

23:51 The Writing Bout; the Importance of Managing Energy to avoid Burnout

35:42 Focusing on the Process, not the Outcome

39:35 Stephen King's Blessing & Approval of Forsaken; the journey to meet King

41:44 James Patterson Collaborations

43:25 Bram Stoker & the Prequel to Dracula, Dracul; Superpower of the Autistic Brain example

46:11 Recognizing Autism in Children

49:11 Future work

Originally released in December 2024, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

For today’s episode, Dr. Hanna Stevens joins me to discuss prenatal brain development and the complex relationship between the placenta, maternal environment, genetics, and the developing brain. Dr. Stevens received her MD and PhD in Neuroscience from the University of Illinois and leads the Psychiatry and Early Neurobiological Development Lab at the University of Iowa Carver College of Medicine, where she is a Distinguished Professor of Psychiatry and holder of the Ida P. Haller Chair.

We discuss the placenta, prenatal stress, serotonin, cortisol, immune function, genetics, and autism, exploring how events before birth may influence brain development and later behavior. This conversation offers a fascinating look inside the womb and at an increasingly important question: when and how do differences in neurodevelopment begin?

Dr. Hanna Stevens https://medicine.uiowa.edu/psychiatry/profile/hanna-stevens

Iowa Healthcare https://uihc.org/childrens/providers/hanna-e-stevens

Psychiatry and Early Neurobiological Development Lab (PENDL) https://stevens.lab.uiowa.edu

Publications https://stevens.lab.uiowa.edu/publications

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0:00 Dr. Hanna Stevens

2:00 Journey into Neuroscience and Psychiatry

8:13 Prenatal Development of Autism

14:02 The significance of NF-kB in Brain Development

23:10 Serotonin; Leukocytes as a window into our Biology; Cortisol

29:02 Steroid Hormones and Stress & Development

34:12 Methylation

40:00 Cell Proliferation & Migration in Fetal Development; Antioxidants

45:56 Oxidative Stress; Mitochondria; Antioxidants

48:30 Quantum Biology/Physics

** Me shaking my head at minute 48:50 is not intended at Dr. Stevens, but at myself because I tell myself not to keep going to the electrons and light for a Cause of Autism to guests

53:19 Future Research & Dorsal Striatum; Volume; Brain Development

Originally released in November 2024, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

For today's episode, Dr. Eric Weiss, MD, explains an exciting medical approach for Autism. Dr. Weiss, who holds board certification in Plastic and Reconstructive Surgery, is a notable figure in regenerative medicine. Dr. Weiss is a Veteran of the U.S. Navy. Dr. Weiss attended Duke University Medical School for his medical degree, completed his General Surgery Residency at the University of California, San Francisco (UCSF), and did his Plastic Surgery Residency at the University of Miami. He has a special interest in using regenerative therapies to address autism.

Dr. Eric Weiss recounts his journey into innovative medical practices, moving away from conventional pharmaceutical treatments. As a father to Marston, his dedication to exploring treatments for autism stems from personal experience. Throughout his story, his enthusiasm for natural healing methods is evident. By the end of this episode, listeners should gain insight into a thoroughly researched medical intervention that's gaining traction in the autism community.

Dr. Eric Weiss, MD: https://northfloridastemcells.com

Educating Marston: https://www.educatingmarston.com

Disclaimer: This is not Medical Advice.

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0:00 Dr. Eric Weiss, MD

1:55 Dr. Weiss's Medical Journey

5:01 Intersection of Autism and Stem Cell Research

12:09 Personal Experience as a Parent with Autism

15:58 Understanding Umbilical Cord Blood Treatment

22:39 The Process of Umbilical Cord Blood Donation

25:55 The Science behind Stem Cell Healing

32:31 Future of Regenerative Medicine

34:24 Natural Healing and Lifestyle, Not Big Pharma

36:56 Mitochondrial Function & Energy Production

39:09 The Impact of Light on Health

41:07 Understanding Inflammation & Modern Disease

44:30 Stem Cell Therapy: Mechanisms & Effects

48:41 The Future of Medicine: Beyond Pharmaceuticals

54:14 Professional Transition into Stem Cell and Regenerative Therapy

58:05 Exploring Cytokines & Interleukins; Patterns of Disease; Dr. Weiss's Contact Info

Originally released in August 2025, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

My guest today is Dr. Nirosha Murugan, a Tier II Canada Research Chair in Biophysics and Assistant Professor at Wilfrid Laurier University. Dr. Murugan explores how physics shapes biological processes, including pioneering research into biophotons, the ultraweak photon emissions produced by living systems.

We discuss biophotons, mitochondria, cellular communication, regeneration, neurodevelopment, and the emerging field of quantum biology, including what these ideas might mean for autism and the future of medicine. The conversation explores what we know, what remains speculative, and what the physical foundations of life might reveal about how living systems communicate, develop, and change.

The Murugan Lab https://themuruganlab.com

Publications https://themuruganlab.com/publications/

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0:00 Dr. Nirosha Murugan

2:16 ads

9:45 Path into Quantum Biology & Biophysics role on organisms; Bioelectricity

13:13 Opsins versus Chromophores; Proteins; Photoreceptors & Light

17:37 The Body Glows & Emits Light; Photomultipliers & Measuring Biophotons

20:37 The Role of Light & Development

21:04 Seed Germination & Human Development (neurodevelopment) Analogy

23:54 Environmental Light & Impact on Health

25:34 Mother's of the original Autistic kids from Leo Kanner

26:46 Light type exposure & Autism

29:50 Mitochondria, Light, & Energy

31:28 Neurocognitive (Dementias) rates & Aging; Reactive Oxygen Species (ROS), Electrons

35:35 Microtubules & Cell Function; Reverse Engineer Oxidative Phosphorylation- ATPase, Electron Transport Chain & TCA Cycle

37:14 Cytochrome C Oxidase, Water, Energy, Four Red Light Chromophores- Heme a, a3, CuA, & CuB, vitamin D receptors

42:11 Tryptophan, Tublin, Microtubules

46:49 The Role of Water & Energy in Cells

48:59 Nature's Impact on Health; Get Outside (!), Oxygen

51:46 Midbrain (mesencephalon), Dopamine, Norepinephrine; Serotonin and Raphe

53:36 Serotonin & Development (remember the sensory map !)

55:11 Biophotons & Seasonal changes; Depression, Pale Autistics

58:02 Cancer & Biophoton Signals

59:50 Biophotons & Coherence, Energy, & Molecular Signals

01:01:53 Psychedelics, Depression, Anxiety, Consciousness

01:05:20 Mitochondria, Memory & Information: What is Information?

01:12:27 Future Direction in Quantum Biology and Medicine; Silos

01:13:36 Ryan's journey into Quantum Biology & Practices, Reversing Autoimmune Diseases

Originally released in June 2024, this conversation is being re-released as part of a selection of guest interviews from the podcast archive.

In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment.

Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement & being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical & Educational Systems.

https://www.semel.ucla.edu/autism/team/catherine-lord-phd

https://childmind.org/bio/catherine-lord-phd/

https://labs.dgsom.ucla.edu/lord/pages/our_team

Autism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638

The mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/

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(0:00) Intro

(3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum

(11:25) The Evolution of Autism Assessment from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments

(16:36) Gaps in the Autism Assessment

(23:15) The Challenges with Understanding the Spectrum of Autism

(29:32) Updates on the Lancet Commission and Profound Autism

(35:19) Barriers with Autism and the Medical Field

(39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, & Subject Switching (understand B3: Fixated Interests)

(44:25) Helping Autistics Across the Life Span

Before asking what is wrong with the world or the person in front of us, perhaps we should ask what might be standing between our own eyes and the light.

What if the plank and the speck are not simply about hypocrisy, but about our ability to see? This episode continues the question of human perception by asking what our histories, assumptions, wounds, projections, and certainty bring into every judgment we make. Jesus does not tell us to ignore the speck or pretend that truth is relative. He says to remove the plank first so that we can see more clearly. From the Parable of the Weeds and the Beatitudes to Plato’s Cave and autism, the discussion explores humility as the recognition that we are never standing outside the field we are trying to understand. Difference can expose assumptions that remain invisible because everyone else shares them, but no one sees everything.

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00:00 The Plank & the Speck; Can We Trust the Way We See?

02:00 The Problem Is Vision; What Are You Bringing to What You See?

02:56 Remove the Plank First; Self Examination & Clearer Sight

03:39 Poor in Spirit; Humility Makes Correction Possible

04:38 The Parable of the Weeds; Seeing the Problem Isn't Seeing the Whole Field

06:04 Jesus Turns the Question Back on You; You Are Inside the Field

06:33 Knowing Yourself; Humility & the Limits of Your Perspective

07:24 What Is Obstructing Your Vision?; Where Clear Sight Begins

07:56 The Eye Is the Lamp; Light, Two Masters & “Therefore, Do Not Worry”

09:06 Autism, Difference & Turning Around in Plato's Cave

09:49 Looking at the World Through Yourself; What Stands Between You & the Light?

10:17 Closing Thoughts

10:55 Sponsors & Resources

X: https://x.com/rps47586

YT: https://www.youtube.com/@FromTheSpectrum

email: [email protected]