Dr. Sabine Hazan is a pioneering gastroenterologist and the first physician to launch a private microbiome testing lab in the U.S. In this powerful episode, she reveals how decades of clinical experience and cutting-edge research have convinced her that the gut microbiome—especially the near-extinction of key bacteria like Bifidobacteria—lies at the root of Autism, Alzheimer’s, cancer, and many chronic diseases. Speaking candidly about the erosion of the doctor-patient relationship, relentless censorship, and the profit-driven forces that have turned medicine into a pill-pushing machine, Dr. Hazan explains why she believes the art of medicine is dying—and how restoring the microbiome could bring it back to life

Progenabiome: https://progenabiome.com

Clinical Trials: https://progenabiome.com/clinical-trials

X: https://x.com/SabinehazanMD

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0:00 Chroma, use "BFCM2025"; Daylight Computer & Fig Tree Golf, use "autism"

2:00 Dr. Sabine Hazan; Gastroenterologist; Microbiome; Fecal Transplant; Covid, Alzheimers, Cancer, Gut Conditions

7:12 The Impact of COVID on Medical Perspectives; Censorship & Narratives

12:26 The Art of Medicine & Relationships- more than just pills (Big Harma)

16:28 Understanding Autism & Microbiome connections; Cancer

21:16 Challenges with Clinical Trials & Funding

26:58 Innovations in Treatment versus the Status Quo

31:44 Censorship & Narrative Control (Profits over Humanity); Dr. Andy Wakefield & Autism

35:52 The Role of Vaccines & Antibiotics

40:16 Future of Microbiome Research & Treatment; Bifidobacteria

47:52 Preserving the Microbiome; Mother's & Autism; Autism Research

54:18 Fighting Censorship in Science; Narrative Control

1:00:56 Lab Testing for Autism; Red Light; Dr. Jack Kruse

1:09:14 Collaborating versus Censorship

1:13:03 Humanity & Health; Profits over Humanity

1:17:27 The Medical Oath; Urgency in Microbiome & Bifidobacteria

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

This episode dives deep into excitatory neurons—the brain’s primary “go” signal—and their outsized role in the Autistic phenotype. We explore how pyramidal neurons, powered by glutamate through AMPA and NMDA receptors, drive lightning-fast information transmission, synaptic hyperplasticity via BDNF, and elevated gamma oscillations (30–80 Hz) in V1, S1, and A1. This overactive excitatory push, paired with reduced parvalbumin and somatostatin inhibition, creates the well-documented E:I imbalance that fuels sensory hypersensitivity, one-trial learning, rigid memory encoding, repetitive behaviors, and the classic distal-connection timing mismatch from early sensory cortices to prefrontal regions.

The Autistic brain gets to the first two stops blazingly fast yet struggles to reach the final destination typical brains arrive at effortlessly.

Inhibition Episodes: https://youtu.be/cjwbog7Rk4c?si=uSaLLNmS5EJLa_iH

https://youtu.be/Oee4L7Vsj4E?si=Y5F2eVudCLhkxNw1

https://youtu.be/PBHVssvoQkM?si=A6SPedQi-Dt-DVO_

E/I https://youtu.be/ETChjRQ0SzQ?si=yIFNovzldwSZRMeT

https://youtu.be/jl0xwjnyXII?si=dmk49CMQo3Uf17ax

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00:00 Excitatory Neurons, Push-Pull System, Parvalbumin Deficiency

03:30 E:I Imbalance, Sensory Hypersensitivity, Repetitive Behaviors

07:00 Pyramidal Neurons, Glutamate, AMPA/NMDA Receptors

10:30 Brain Regions: DLPFC, Anterior Insula, V1 S1 A1

14:00 Amygdala Misnomer, Low Road vs High Road, Emotional Hub

18:30 Receptors: AMPA 1-5ms, NMDA 10-200ms, mGluR Modulatory

22:00 Gamma Oscillations, BDNF Hyperplasticity, Sensory Overload

25:30 Distal Connections, Point-A-to-Point-B Timing Mismatch

29:00 BDNF Critical Period, One-Trial Learning, Rigid Memory

32:30 TRN Dysfunction, Repetitive Behaviors, Corticostriatal Circuit

34:30 Go-Signal vs Stop-Signal, Push-Pull Bowling Bumpers

36:00 Rubenstein & Merzenich 2003, E:I Imbalance Foundation

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39:32 Chroma Light Devices, use "autism" for 10% discount

42:35 Reviews/Ratings & Contact Info

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

Today's episode examines the thalamic reticular nucleus (TRN), a GABAergic structure that filters sensory inputs to the thalamus, influencing sensory processing and attention in Autism. We'll explore how TRN dysfunction contributes to sensory hypersensitivity, repetitive behaviors, and cognitive strengths like visual thinking. We cover the TRN’s visual, somatosensory, auditory, and limbic sectors, using vivid analogies like a security guard and staring contest to illustrate its role. These mechanisms are linked to the Autistic phenotype’s challenges and unique perceptual abilities.

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00:00 Thalamic reticular nucleus (TRN), GABAergic neurons, sensory gating

03:42 TRN functional roles, sensory gating, attentional modulation, brainwave generation, neuro-overload prevention

07:44 TRN inputs, basal ganglia, repetitive behaviors

11:15 Cognitive flexibility, prefrontal cortex, dorsal striatum, rigid responses, Autistic rigidity

14:38 TRN outputs, feedback inhibition, excitatory neurons, sensory tuning, gamma oscillations

18:35 Burst firing, tonic firing, sensory suppression, attention regulation, sleep spindles

22:12 Visual sector, "staring contest" analogy, parvalbumin & VIP interneurons, lateral geniculate nucleus, visual gating

25:50 Somatosensory sector, ventral basal complex, tactile hypersensitivity, sensory-emotional integration

29:15 Auditory sector, medial geniculate nucleus, auditory sensitivity, social processing deficits, clusters of noises in the environment, Beatles song comparison

33:00 Limbic sector, mediodorsal nucleus, anterior insula, emotional regulation, OCD-like behaviors, Leading the way in Adaptive Responses

36:47 TRN security guard analogy, sensory control, thoughts and plans, high-intensity stimuli

40:20 Visual attention, high gamma activity, subtle environmental cues, Autistic cognitive strengths

41:06 Daylight Computer Company, use "autism" for $50 discount

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X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

Today's episode explores the role of inhibitory neurons & the Sonic Hedgehog (SHH) gene in shaping the Autistic phenotype, focusing on the excitation-inhibition imbalance that drives sensory hypersensitivity and cognitive challenges. Through a neuroscience lens, the episode connects these mechanisms to heightened gamma activity.

Ben Ari Episode https://youtu.be/jo-ffwF9u0Y

Parvalbumin Interneurons episode https://youtu.be/PBHVssvoQkM?si=t8WYGlcHcv7WiE-T

Visual Thinking Part 1 https://youtu.be/XqQ8jCvWzYc?si=lffUEjGHjWj4mGOM

Neurulation Part 1 https://youtu.be/gZdg9bX3Nuw?si=xvwtlz-p1hPHI8FA

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00:00 - Autistic phenotype, excitation-inhibition imbalance, sensory hypersensitivity, cognitive deficits

03:40 - Inhibitory neurons, GABA receptors, GABA-A, GABA-B, GABA-C, tonic inhibition

07:24 - Tonic firing, burst firing, phasic firing, neural oscillations, sensory processing

08:31 - Sonic Hedgehog gene, neural development, GABAergic identity, thalamic reticular nucleus (TRN)

14:48 - Parvalbumin interneurons, fast-spiking, gamma oscillations, sensory gating, dorsolateral prefrontal cortex

18:22 - Parvalbumin dysfunction, sensory hypersensitivity, visual cortex (V1), EI imbalance, brain-derived neurotrophic factor (BDNF)

22:02 - Somatostatin interneurons, feedback inhibition, dendritic modulation, sensory adaptation, hippocampus

25:43 - Vasoactive intestinal peptide (VIP) interneurons, disinhibition, pyramidal activity, attention, social processing

29:30 - Calbindin interneurons, calretinin interneurons, dendritic inhibition, sensory processing, anterior insula

33:15 - Purkinje cells, cerebellum, motor control, cognitive timing, cell loss in autism

36:00 - Evolutionary perspective, parvalbium density, neural circuit stabilization, sensory-cognitive processing

39:25 - Gamma activity, visual processing, retina, lateral geniculate nucleus, attention to detail, autistic self

39:52 Daylight Computer Company, use "autism" for $50 discount

42:13 Chroma Light Devices, use "autism" for 10% discount

45:17 Reviews & Contact Info

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

In this episode, we explore the connections between Autism and Parkinson's, focusing particularly on the basal ganglia and its substructures, notably the substantia nigra within the midbrain. We discuss how the substantia nigra, known for its high concentration of neuromelanin, plays a critical role in these disorders. The episode examines how neuromelanin, a dark pigment, not only absorbs all frequencies of light but also has antioxidant properties, binds metals, and acts as a neuroprotector. This discussion leads into the broader implications of environmental signals, particularly light, on human biology, touching on how modern changes in light exposure might affect these conditions.

We examine the role of tyrosine in the synthesis of neuromelanin and its derivatives like dopamine, which are crucial for neural function. We look at how deficiencies or imbalances in these pathways could lead to the symptoms observed in Autism and Parkinson's, including motor function issues. The conversation also covers the direct and indirect pathways in the basal ganglia, explaining how these pathways facilitate or inhibit movement, respectively, and how their dysfunction can manifest in the characteristic motor symptoms of both disorders. We also touch on the significance of thyroid function, particularly the roles of T3 and T4 hormones, in brain development and neuron health, tying these elements back to the overarching theme of energy loss and transduction in both Autism and Parkinson's.

Autism and Parkinson's are a lack of, or a loss of, energy.

Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB: https://youtu.be/2-IA_gunXbw

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0:00 Autism and Parkinson's; Basal Ganglia; Substantia Nigra; Neuromelanin; Internal Calculators

2:15 Tyrosine; Chromophores; Aromatic Amino Acids

3:50 Biological Energy; Mitochondria; Environmental Signals; Cytochrome C Oxidase; Autism Research Miss

6:20 Deep Brain Stimulation

6:48 Neuromelanin

9:02 Reverse Engineer ATPase

10:48 Tree Examples

11:45 Hypoxia and loss of energy & dopamine

12:26 Eyes, hair, & skin; RPE; efficiency & power; What is Light?

13:58 Light; Information & Energy; electromagnetic; wave-particle duality; sunlight versus artificial light

17:08 Thyroid; T3 & T4; Iodine

18:31 Roles of T3

23:00 Loss of energy in the womb & Autism research

25:00 Melanin + Water = Electrons

26:40 Basal Ganglia; "Motivations" & Movements; Direct Pathway

30:55 Indirect Pathway

32:52 Go, No-Go; Action selection, learning & habits; fine motor skills

34:18 Parkinson's and loss of timing & energy; modulating the two pathways & dopamine

37:07 Reviews/Ratings & contact info

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

In this episode, Dr. Ahmad Ammous, MD, exposes the profit-driven "profit mills" of modern medicine, critiquing its reliance on pills to manage symptoms rather than address root causes. Drawing from his journey as an internal medicine physician, he challenges pharmaceutical-centric practices and delves into quantum biology’s healing potential, exploring topics like light-driven energy production through melanin’s water-splitting mechanism, cytochrome sensitivity to red and blue light in the electron transport chain, and circadian biology’s role in melatonin and cortisol regulation. Dr. Ammous offers practical solutions, such as paleo diets and sunlight exposure, to optimize health, while advocating for decentralized systems, including Bitcoin, to empower patients over profits.

Modern Medicine is Profits over Humanity

THIS IS NOT MEDICAL ADVICE

Centralized Medicine = PROFITS over HUMANITY

Dr. Ammous X https://x.com/AmmousMD

Dr. Ammous website https://ammousmd.com/?v=eb65bcceaa5f

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0:00 Dr. Ahmad Ammous, MD; Internal Medicine Medical Doctor

5:22 The Harms of Medical School

8:13 The Profit Mill in Centralized Medicine & Banks; Rockefeller Medicine & Fed Reserve; Flexnor Report; Big Harma (Pharma)

14:21 The Role of Light in Life & Health; Isolated Blue Light is the new smoking

17:09 Melanin

20:13 Melanin's Role as an Antioxidant & Detoxing

23:07 Autism & Sensitivities

26:24 Melatonin's Additional Roles

29:10 The Harms of Artificial Light on Health; POMC; Cortisol

31:18 Artificial Light at Night & Sleep; Massive Hormone Disruptor

33:21 The Electron Transport Chain & OXPHOS; Cytochromes; Biological Energy; ROS; Red Light & Cytochrome C Oxidase

38:21 The Massive Scams of Heart Prescriptions, Guidelines, Cholesterol and Statins & a leading cause of death is still Heart Disease, Heart Attacks; Big Harma

49:19 Environmental Factors & Modern Diseases

53:55 Covert Push:Pull Tactic on Humans from Medicine & Health Insurance; The Profit Mills

58:38 Autism & Lifestyle; Circadian Rhythms, Diet, & GI

59:35 Daylight Computer Company, use "autism" for $50 discount

1:03:00 Chroma Light Devices, use "autism" for 10% discount

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

Today's episode is all about Autism and its associated communication disorders, as outlined in the DSM-5-TR, focusing on social communication disorder (SCD), childhood onset fluency disorder (stuttering), speech sound disorder, and developmental language disorder (DLD), which affect 50-70%, 4-22%, 20-30%, and up to 50% of Autistic individuals, respectively. We explore neural underpinnings, highlighting hypoactivation in brain regions and brain waves are discussed that are critical for social cognition, alongside disrupted connectivity in networks like the arcuate and superior longitudinal fasciculi. Two genes- FOXP2 and CNTNAP2 are also discussed.

Other relevant episodes:

Decoding the Brain: How Reading works in Autism and Dyslexia https://youtu.be/s1-7HZchy84?si=-r9foWP8Gmw-Wsx2

Autism and Speech & Language https://youtu.be/jhAA-UWduKg?si=TfVWi9AfbFZgv8XV

Autism and Sensory Processing part 2 https://youtu.be/iWy9Rligzic?si=2LATDK0bPl6jjat9

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00:00 - Introduction to Autism and Communication Disorders; DSM-5-TR, social communication, pragmatic deficits, stuttering, speech sound disorder, developmental language disorder

04:02 - Brain Regions and Social Cognition; medial prefrontal cortex, temporal parietal junction, superior temporal sulcus, "theory of mind", hypoactivation

06:01 - Autistic Phenotype and Neural Connectivity; Mirror neurons, sensory processing, under-connectivity, arcuate fasciculus, superior longitudinal fasciculus

11:38 - Brainwave Patterns and Measurement Techniques; EEG, MEG, gamma band, alpha band suppression, fMRI, DTI & Factional Anisotropy

16:27 - Genetic Contributions to Communication; FOXP2, CNTNAP2, neural circuits, synaptic plasticity, language processing

19:56 - Social Communication Disorder (SCD); Overview pragmatic language, non-verbal cues, autism differentiation

24:45 - Childhood Onset Fluency Disorder (Stuttering); basal ganglia, motor planning, rTMS, dopamine signaling, Go-Stop, Go-Stop, Go-Stop...

30:05 - Speech Sound Disorder Speech; Broca’s area, superior temporal gyrus, articulation errors, PROMPT therapy

35:25 - Developmental Language Disorder (DLD); Broca’s area, Wernicke’s area, language comprehension, early intervention

40:56 - Importance of Early Intervention; speech therapy, neural connectivity, personalized interventions, neurofeedback.

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

This week's episode is all about Reading. We will go through the entire process from the moment light hits the retina (50-100ms) to formulating speech (600ms or so). That is, either speaking out loud or silently speaking while reading, a phenomena called subvocalization. We do this when reading to the self. Either way, we speak while reading.

We will compare so called normal readers, the Autistic phenotype, and dyslexia, and at times the odd contrasts of the Autistic phenotype AND dyslexia. Lots of neurobiology, measurement instruments, brain waves (oscillations, frequencies), however, I will hopefully provide easy to understand analogies.

The entire reading process is covered.

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00:00 - Overview of reading process and neurobiology

03:28 - Visual processing in V1 (primary visual cortex), V2-V4 (secondary visual cortex)

4:42 - Neuroplasticity of Blind using V1-V4 for Braille

07:17 - Neural oscillations (Delta, Theta, Alpha, Beta, Gamma)

10:07 - Visual word form area (VWFA) recognizes patterns, begins sequencing letters & recognizes the word, Example: "d-o-g" & 'd' not 'b', 'o' not 'c,' 'g' not 'p.'

13:01 - Phonological processing in temporal-parietal cortex

15:54 - Fractional anisotropy (FA) & Diffusion Tensor Imaging (DTI) and arcuate fasciculus; Myelination, Water Flow, Garden Hose example

18:06 - Detailed discussion of orthographic processing begins (VWFA’s role in recognizing visual word forms)

21:26 - Detailed discussion of cerebellum’s role in eye movements begins (Purkinje cells and saccades)

24:07 - Detailed discussion of spelling difficulties begins (orthographic processing challenges in autism/dyslexia)

27:41 - Detailed discussion of semantic integration begins (delays in dyslexia, inferior frontal gyrus)

30:55 - Detailed discussion of orthographic confusion begins (e.g., "except" vs. "expert")

33:30 - Detailed discussion of phonological processing begins (temporal-parietal cortex mapping words to sounds)

34:18 - Cerebellum mentioned regarding tongue movements (Purkinje cells refine timing for speech)

36:10 - Subvocalization in silent reading

37:07 - Oscillations in VWFA for autistic phenotype; Comprehension lags in Autism due to delayed N400

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41:40 Chroma Light Devices, use "autism" for 10% discount

44:52 Reviews/Ratings, Contact Info

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

Today's episode continues with visual thinking. We will learn more about the accelerated learning patterns with visual thinking and the Autistic phenotype. Autistic individuals create detailed mental "catalogs" of images and experiences, much like AI’s data processing. We explore Temple Grandin’s vivid descriptions of thinking in pictures, alongside early observations from Kanner (1943) and Asperger (1944), who noted autistic intelligence in their "little professors." The discussion covers weak central coherence theory & specific details drives exceptional learning but can complicate social interactions and broader contextual understanding.

We will discuss the Autistic brain and machine learning, from pattern recognition to iterative refinement. Enhanced neural connections, like those linking the visual and frontal cortex, enable Autistic individuals to excel in tasks requiring precision, such as spotting subtle differences or memorizing facts. The episode contrasts this unique cognitive style with societal norms, advocating for embracing these strengths.

Frith & Happe Weak Central Coherence https://link.springer.com/article/10.1007/s10803-005-0039-0

Visual Thinking part 1: Neurobiology & Autistic's Intense Inner World https://youtu.be/XqQ8jCvWzYc?si=3cEIm1omi0JUAKSK

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00:00 - Introduction to Visual Thinking; "movies" in the mind, and its impact on learning.

02:02 - Historical Context of Autism References to Leo Kanner (1943) and Hans Asperger (1944) highlight early observations of autistic intelligence, with terms like "little professors" and "autism" (from "autos," meaning self)

04:01 - Social Norms vs. Autistic Phenotype The autistic cognitive style contrasts with societal expectations, which favor fitting individuals into predictable "boxes" for evaluation and acceptance, making social integration and education challenging for autistic individuals.

06:01 - Cataloging and AI Parallels; mental catalogs & specific images or experiences, similar to AI & machine learning, catalogs for categories

08:46 Weak Central Coherence Theory; local, detail-oriented processing over global integration, enabling strengths like spotting hidden shapes

10:28 Enhanced Perceptual Functioning, visual and auditory domains, allowing precise cataloging of sensory details, tasks & precision.

12:02 Anecdotal Person Comparison & Associative Learning

15:30 Pattern Recognition and Detail Focus

18:26 Types of Visual Thinkers

20:36 Neural Connectivity

23:22 Perceptual Learning and Neuroplasticity; Accelerated learning

27:04 AI and Autistic Brain Similarities

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35:53 Chroma Light Devices, use "autism" for 10% discount

38:59 Don't underestimate this Autistic Phenotype.

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]

Today's episode is all about visual thinking. We will explore vivid mental imagery and sensory processing. We will cover why Autistic individuals process detailed "pictures and movies" in the mind, exemplified by an anecdote of visualizing oak tree bark with tactile detail. Sensory challenges are highlighted, with a Bee Movie analogy illustrating the intense, efficient visual input. The Autistic sensory journey is described as fast but rocky, contrasting with non-autistic processing. Hyperconnectivity in visual pathways amplifies detail-oriented cognition, often leading to sensory overload.

The episode explains how retinal ganglion cells and visual cortex hyperactivity enhance imagery in Autism. Kanner and Asperger’s observations underscore visual memory strengths and technical interests, like pattern recognition. Increased mini-column density and reduced inhibition boost local processing but risk overload. Temple Grandin’s insights show visual thinking’s strengths in tasks like designing animal pathways, though social tasks challenge due to weaker prefrontal connectivity. The Autistic brain’s wiring is framed as a unique strength, fostering intense, detailed cognition

Temple Grandin https://www.templegrandin.com/templegrandinbooks.html

Sensory Processing part 1 https://youtu.be/HTnFm8nY4oY?si=4Xso_tI_hMwhY_SX

Sensory Processing part 2 https://youtu.be/n31gyLb4ddM?si=CouaBhiVm8KixtG-

Supplementing Relationships part 1 https://youtu.be/lglEGQ7pSlc?si=ncpla784LxOyUcQc

Supplementing Relationships part 2 https://youtu.be/W8E2B7Qu4mg?si=UJE850SwvPmtOmEk

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00:00 Introduction to Visual Thinking

02:00 Anecdote: Oak Tree Visualization; tree bark, tactile

05:50 Sensory Processing Challenges; overload, information rate, avoidance

09:40 Anecdote: Bee Movie Analogy; synchronized, intense, fast

13:30 Autistic Sensory Rates/Speeds

17:20 Eye Biology and Neural Relays; Retinal ganglion, SHANK3; Building Models details-to-general

21:10 Magnocellular vs. Parvocellular Pathways; Motion, color, glutamate, GABA signaling

25:00 Visual Cortex Hyperactivity; V1-V4, fMRI, synaptic pruning, details

28:50 Mini-Columns and Sensory Overload; Neural units, inhibition, dense connections

32:40 Kanner and Asperger Insights; Social isolation, technical interests, patterns

38:39 Daylight Computer Company (and Daylight KIDS !), use "autism" for $50 discount

40:54 Chroma Light Devices, use "autism" for 10% discount

44:07 Reviews/Ratings & Contact Info

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]