In this session join Drs. Peter Kotanko, Research Director of the Renal Research Institute & Jeroen Kooman, Professor at Maastricht University in the Netherlands, discuss the pathophysiology of hypoxemia and hypoxia in patients on dialysis will be discussed, as well as the mechanisms by which these phenomena are related to adverse outcomes. The maladaptive responses in patients on dialysis will be discussed in the context of comparative physiology, with the example of Sherpa, which shows a highly adaptive response to ambient hypoxia. It will also be discussed how lessons from comparative physiology might be of potential benefit to patients on dialysis.

This session discusses Dr. David Keane's (Leeds Teaching Hospitals' Clinical Scientist) research interests in general and particularly a piece of research that aimed to describe the time of onset of intradialytic hypotension during hemodialysis sessions. This will lead to discussions, with Dr. Peter Kotanko (RRI's Research Director) of what the research can teach us about how we prescribe the length and frequency of hemodialysis sessions.

A discussion between Drs. Peter Kotanko and Richard Weller on the latter's research into the effects of sunlight on systemic health. Dr. Weller describes two recent epidemiological studies he has performed in which he demonstrated an inverse relationship between sunlight exposure and blood pressure, and COVID mortality. He has previously demonstrated NO release from UV exposed skin to the circulation which may account for these effects.

Frontiers in Kidney Medicine and Biology is an interview series presented by the Renal Research Institute (RRI) and hosted by Research Director, Peter Kotanko, MD, FASN. Each episode of the Frontiers in Kidney Medicine and Biology series showcases an in-depth conversation with thought leaders from around the world. These foremost scientists and doctors share their insights into the latest advances in renal research and beyond, and assert how they are taking medicine, research, and science to exponentially higher levels. Each episode of the is available on the RRI website, YouTube channel, and wherever you listen to your podcasts.