John and Steve ask: Are we in a paradigm shift where no one writes code anymore — or is that just hype? What happens when you can reprogram aging at the cellular level? And if AI agents can run your life in the background, what's left for humans to actually do?

Topics:

• The coding agent revolution: Claude Code, Opus 4.5, and whether engineers are becoming system architects or just prompt engineers
• Vibe coding reality check: Why non-technical people are shipping apps, and the era of personalized computing
• Hyper-personalization: From algorithmically fractured media diets to genetics-informed nutrition via your phone
• GLP-1s and the longevity frontier: Why these molecules do more than suppress appetite, and the case for leapfrogging the Anglosphere back to baseline health
• David Sinclair's ER-100: The information theory of aging, Yamanaka factors, and why the eye is the least reckless place to start reprogramming cells
• The clinical trials bottleneck: We don't need more molecules — we need faster trials. Why AI in drug discovery is mostly hype
• AI personal assistants: ClawBot, ambient agents, and the future where your phone does everything while you focus on what matters

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(0:00): Opening

(0:50): The coding agent shift — interviews, Claude Code & Opus 4.5

(9:00): Vibe coding and personalized computing

(12:00): Hyper-personalization and the fragmentation of culture

(15:00): Health data, genetics, and the future of nutrition

(21:00): Getting back to baseline — longevity and GLP-1s

(25:00): The information theory of aging and GLP-1 deep dive

(39:00): David Sinclair's ER-100 gene therapy

(50:00): Clinical trials, the bottleneck problem, and AI in drug discovery

(1:13:00): AI personal assistants and ambient agents

John and Steve ask: Why do pessimists always sound smart but optimists make money? How did one chemical process (Haber-Bosch) enable half of humanity to exist? Why is playing whack-a-mole with progress actually a good sign?

Topics:

• Solutionism: William Crooks, Paul Ehrlich & the false dichotomy of optimism vs. pessimism
• The Haber-Bosch process: Why a third of humanity owes their existence to ammonia synthesis
• France's nuclear triumph: When electricity prices dropped to zero and civilizational capacity pays off
• AI coding reality check: Hundreds of hours of vibe coding, the bug whack-a-mole problem, and what actually works in finance
• Safety as progress: From Underwriters Laboratories to the FDA, why solutions create new problems
• Why doesn't this exist yet: Colic research, liquid biopsies, and the false positive cascade in cancer screening

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(0:00): Opening

(2:30): What happened this week

(2:30): GPT 5.2

(7:20): Specialisation of AI Models

(12:30): AI Enterprise Use Cases

(20:50): Maximising LLM value

(24:00): Free Energy in France

(31:00): Crawford's Techno-Humanist Manifesto - Solutionism, Part 1

(55:00): Solutionism, Part 2

(1:12:00): Why doesn't this exist yet?

John and Steve ask: If modernity gives us more choice than any generation in history, why do so many people feel worse off? What does a “good life” actually look like in 2024?

Topics:

• AI scientists & the future of discovery: Can tools like Cosmo (Edison/Future House) remake how science is done?
• Wealth taxes, billionaire flight & network effects: Will New York and London actually depopulate, or are they too “sticky” to leave?
• Jason Crawford’s “good life”: Beyond GDP and happiness surveys — what values should progress really be judged on?
• Work, love, knowledge & beauty: From bullshit jobs and trad-farm aesthetics to dating apps, Duolingo and AI art.
• Modernity as a bundle: Supermarket abundance, Ozempic, distraction-free tech and “protect me from myself” products.
• Millennials, housing & fertility: Are we genuinely worse off than our grandparents despite a century of progress?
• Choice, agency & templates: Why some people thrive on infinite options — and why others need structured paths.
• Why doesn’t this exist: A cognitive fitness tracker and a minimalist Spotify “iPod” for deep work.

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(0:00): Intro

(2:01): NYC elections & exodus of wealth

(7:21): AI, Edison scientific, & equalising the scientific playing field

(18:00): Jason Crawford and defining the ‘good life’

(24:11): Freedom and autonomy as the core of the good life

(26:51): Core values of the good life

(35:21): Progress has afforded us a bundle of choice

(39:30): Progress is relative to the periods of comparison

(52:52): Why doesn’t this exist?

(57:20): Wrap-up

John and Steve explore: Are humans a cancer on Earth, or the most remarkable species? What future are we building with AI?

Topics:

• Sora vs Thinking: OpenAI's slop engine vs Anthropic's manifesto — who has the mandate of heaven?
• The death of humanism: When did "human extinction might be good actually" become respectable?
• Technology as human nature: Why the iPhone is as natural as the spear
• Malthusians were wrong (again): From famine predictions to obesity epidemics
• Agency vs inevitability: Are we passive observers or active creators of the future?
• The responsibility of builders: Every choice about what to build is a moral choice

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(00:00) Introduction

(00:31) Welcome to Episode 2

(01:11) OpenAI integrations & the last-mile problem

(03:00) Commoditization hell & frontier model economics

(04:52) Concrete examples: Spotify, Zillow, Expedia

(06:40) LLM personalities & brand loyalty

(09:36) The prompt window & memory

(10:40) Sora 2 launch & AI-generated slop

(11:49) Sam's avatar & CCTV memes

(13:40) Meta's Vibes vs Sora's social features

(15:49) Entertainment as slop

(18:31) Anthropic's "Keep Thinking" campaign

(19:54) Say no to slop — the mandate of heaven

(21:00) Machines of Loving Grace manifesto

(22:20) Think Different redux

(22:42) AI encroaching on human territory

(26:00) Honda's Power of Dreams

(27:02) Jason Crawford's "Ode to Man"

(28:00) The death of humanism

(29:20) When did anti-natalism become mainstream?

(30:28) Climate change & anti-human sentiment

(31:20) Malthusians & the fertility trap

(32:20) Haber-Bosch & human ingenuity

(33:00) Progress as stress vs progress as solution

(34:20) Obesity, not famine: The Malthusian surprise

(36:20) Technology as expression of human nature

(37:40) The cumulative human project

(38:20) Brutality without technology

(39:00) Cloud seeding & playing God

(40:04) Backbreaking work & technological relief

(41:16) Lapvona & life before modernity

(42:00) Egyptian agriculture & cosmic theology

(43:40) Controlling our environment

(44:00) Agency vs fatalism

(45:20) Doom vs E/acc vs Crawford's third way

(45:45) How much agency do we really have?

(46:20) Capitalism demands progress

(47:20) Agency can be taught

(48:20) Free will & self-fulfilling prophecy

(48:40) Progress isn't linear: The medieval dark ages

(50:00) Agency is accessible to everyone

(50:38) The Sovereign Individual

(51:32) Who decides what's responsible?

(52:20) Decision funnels & the Network State

(53:40) The Museum of Passion Projects

(55:00) Moral obligation of builders

(56:00) Why doesn't this exist: Neurodegenerative diseases

(57:29) Alzheimer's & personal genetics

(58:20) The 2006 amyloid hypothesis fraud

(59:40) Academic incentives gone wrong

(01:00:27) The man who can't get Alzheimer's

(01:01:20) Gene editing vs mRNA vaccines

(01:02:20) Food allergies & pollen misery

(01:03:40) He Jiankui & the CRISPR babies

(01:05:00) mRNA as the better path

(01:06:00) Pandora's Box & AGI parallels

(01:06:58) Why doesn't this exist yet: AI to-do list app

(01:08:00) Minimalist phone apps

(01:09:00) ChatGPT forgets my weekend tasks

(01:11:00) Proactive AI & location awareness

(01:11:32) Accountability & push notifications

(01:12:40) CBT: Everything is your fault

(01:13:20) Memes vs productivity nudges

(01:13:40) AI doesn't know what time it is

(01:14:20) Wrap-up & Crawford's thesis

John and Steve kick off by asking: What are the real frontiers of progress, and what’s holding us back?

Topics:

• Apple vs Google

• E/ACC vs Philosophy of Progress: Is acceleration always good, or should tech serve human flourishing?

• Why innovation thrives in extremes (war, prosperity) and stalls in the middle.

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(00:00) Introduction
(01:00) Life-fit vs self-fit and Charlie Munger’s “inner scorecard”
(03:00) the “Great Lock-In,” and escaping the permanent underclass
(05:00) Apple vs Google — stagnation, innovation, and Banana by Google
(07:00) Product plateau and the equilibrium state of hardware
(10:00) Apple as luxury brand; design vs technology
(12:00) Enduring design
(14:00) Flip phones vs. brain interfaces
(16:00) Dangers of AI autonomy
(17:00) “Techno-Humanist Manifesto”
(18:00) 1960s optimism
(20:00) Techno-humanism vs effective accelerationism (E/acc)
(23:00) Doom vs E/acc vs Crawford
(26:00) Human well-being as the metric for progress
(29:00) Luddites vs. automation
(31:00) Taking modern infrastructure for granted
(33:00) Automation & translation

(36:00) Why physical tech lags behind software
(40:00) Defense tech as the engine of innovation
(44:00) Conflict as a driver of technological progress
(47:00) Forgetting pre-modern misery
(49:00) Bridging the global development gap
(50:00) Modernity as a bundle
(52:00) Slopware vs. real innovation
(54:00) Hard science vs SaaS
(57:00) Funding moonshots
(59:00) Oddball geniuses
(01:01:00) Anglo-Celtic inventiveness and prosperity cycles
(01:05:00) Ingenuity in prosperity