Flashing lights offer hope for a radical new non-drug treatment for Alzheimer’s disease, according to research at Massachusetts Institute of Technology. It found that flickering at a frequency of 40 times per second induced brain waves that helped clear toxic proteins in a study on mice. John Murray-Brown talks to Clive Cookson, the FT's science editor, about the breakthrough.

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Matteo Renzi has lost his referendum on constitutional reform, plunging the country into political and financial crisis. Patrick Jenkins, the FT's financial editor, discusses the fallout for the banking sector with Martin Arnold, banking editor, Rachel Sanderson, Milan correspondent, and Davide Serra of investment fund Algebris. Music by Kevin MacLeod

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Mexico has invited outside investors into its energy sector after a gap of nearly 80 years. It sold several deep water exploration blocs in the Gulf of Mexico, with China being one of the big winners. Jonathan Wheatley talks to David Sheppard, the FT's energy markets editor, about the reforms, with clips from an interview they conducted recently with José Antonio Meade, Mexico's finance minister, and José Antonio González Anaya, chief exec of state oil company Pemex.

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A fierce Russia-backed aerial assault on Syria’s rebels in Aleppo has helped regime forces capture more than a third of rebel-held districts. Now it appears the rebels are in secret talks with Russia to end the fighting in the city. John Murray-Brown talks to Erika Solomon, FT Middle East correspondent about what's behind this latest development in the conflict

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Italy's prime minister Matteo Renzi has vowed to step down if, as polls suggest, he loses Sunday's referendum on constitutional reform. Some fear this could hit the economy and banking sector hard. John Murray Brown discusses the likely repercussions with Tony Barber, the FT's Europe editor, and James Politi, Rome bureau chief.

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Earlier this month, Narendra Modi, India’s prime minister, declared 86 per cent of the country’s bank notes invalid in a measure aimed at curbing the country’s black market. But the immediate effect was to slam the brakes on the economy. Jonathan Wheatley discusses the longer term consequences with Kiran Stacey, FT correspondent in New Delhi.

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There have been encouraging signs recently that tech companies are expanding their operations in London, despite Brexit. Chris Nuttall discusses whether the trend can last with Madhumita Murgia, the FT's European technology correspondent, and Judith Evans, property correspondent.

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In his first Budget statement, Philip Hammond said he wanted to get the economy 'match fit' for Brexit, but admitted that worsening public finances would mean the UK needed to borrow more. Barney Thompson talks to Chris Giles, FT economics editor, and George Parker, political editor, about the chancellor's most striking announcements.

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Brussels plans to tighten rules for overseas banks operating in the EU in a tit-for-tat step against the US that will raise costs for big foreign lenders. Does this mean the global consensus on bank rules is breaking down? Patrick Jenkins, FT financial editor, discusses the issue with colleagues Martin Arnold and Caroline Binham, and hears the view of Andrea Enria, chairman of the European Banking Authority. Music by Kevin MacLeod

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Saudi Arabia is preparing to lift the lid on one of the global energy industry's most closely guarded secrets - how much crude lies beneath the desert kingdom's sands. David Sheppard interviews the FT's oil and gas correspondent Anjli Raval

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