Can you train hard on GLP-1 medications without sacrificing strength, muscle, or performance? Miles and Amara unpack what these drugs actually do in active bodies, using the Serena Williams ambassador news and WADA’s interest as the backdrop for a bigger conversation about lifting, running, and competing on GLP-1s.

Listeners learn how GLP-1s change fullness, slow digestion, and create a quiet calorie deficit that can derail fueling. They learn what current research and coaching experience say about muscle loss and how resistance training plus protein can protect lean mass. They also learn how to use mechanical eating and scheduled hydration to avoid low energy availability and RED-S while training. Released on a Tuesday, this conversation grounds the GLP-1 trend in a full-spectrum view of strength, health, and performance.

Does adding cardio actually kill your strength gains, or has gym culture been wrong for decades?

Miles and Amara revisit the classic interference studies, explain what is really happening at the molecular level between mTOR and AMPK, and show how easy Zone 2 bike sessions can support rather than sabotage lifting. Listeners learn how the Hickson study and a 2012 meta-analysis shaped the “cardio kills gains” myth, how training order and a simple three-hour window after hard cardio reduce interference, and how to choose between running and cycling based on eccentric stress and recovery. A practical weekly hybrid template and small, actionable programming tweaks help you plan strength and cardio together with confidence every Tuesday and beyond, supporting a genuinely full-spectrum approach to training.