GasGasGas - Anaesthetic Science for Anaesthesia!

This FRCA Primary Podcast episode establishes the scientific foundation for understanding how Local Anaesthetic drugs work, why they behave differently and how to use them safely. By the end, you'll understand nerve physiology, sodium channel blockade, drug classification, and the basics of local anaesthetic toxicity.

Show notes at: https://gasgasgas.uk/local-anaesthetic-fundamentals-for-the-frca/

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GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

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Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

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Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

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"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

Opioids are a significant cornerstone of anaesthetic practice, forming part of the triad of anaesthesia with their analgesic properties. We utilise these analgesic properties not just because "surgery hurts," but also because our interventions cause physiological upset - laryngoscopy being a prime example.

Show notes at: https://gasgasgas.uk/comparing-opioids-for-the-frca-primary/ 

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GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

Remifentanil is an anaesthetist’s dream: ultra-short acting, reliably titratable, and deeply potent. This episode takes a dual-pronged approach, covering both the FRCA-relevant pharmacology of remifentanil and introducing the Minto target-controlled infusion (TCI) model. 

Show notes at: https://gasgasgas.uk/remifentanil-and-minto-tci-model/

================================================

GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

In this explainer episode of GasGasGas, we make our descent into the joyful complexities of neuraxial opiate pharmacology.

Why do we bother putting opiates into this space at all? What governs their journey, how do they behave once administered, and what clinical pearls can be drawn from their behaviour? This episode follows the journey of a single opioid molecule through the fatty labyrinth of the epidural space, across barriers, and into its final destination: the dorsal horn of the spinal cord, before it potters away to realms of mischief in the brainstem.

Show notes at: https://gasgasgas.uk/neuraxial-opiate-kinetics-for-the-frca-primary/

================================================

GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

In this episode of Gas, Gas, Gas, we drill a figurative oil well into the pharmacology of diamorphine — also known by its more notorious street name, Heroin/Smack/Golden Brown. Diamorphine is a synthetic diacetylated derivative of morphine, and this episode details its mechanism of action, clinical applications, pharmacokinetics, pharmacodynamics, and side effect profile. The episode is structured to support FRCA Primary revision with an irrelevant clinical anecdote (but sound advice I would argue) and exam-focus.

Show notes at: https://gasgasgas.uk/diamorphine-for-the-frca-primary/ 

================================================

GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

We are plunging into the pharmacology of oxycodone, a potent semi-synthetic opioid analgesic widely used in perioperative and chronic pain settings. We explore oxycodone's mechanism of action, pharmacokinetics, and pharmacodynamics

We dissect its action on mu-opioid receptors, compare it to morphine and other opioids, and review evidence regarding oral vs intravenous formulations, metabolism via CYP450 enzymes + implications for renal and hepatic impairment.

It's lost is license for prolonged release versions in acute pain!

Show notes at: https://gasgasgas.uk/oxycodone-for-the-frca-primary/

================================================

GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

In this episode of the GasGasGas Primary FRCA podcast, we explore methadone, its pharmacology (pharmacodynamics and pharmacokinetics), diverse receptor activity, and its clinical uses.

While traditionally associated with managing opioid dependency, methadone’s unique pharmacodynamics and potential utility may have been overlooked given its other uses…

Show notes at: https://gasgasgas.uk/methadone-for-the-frca-primary/

================================================

GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

This episode takes a dive into the detailed pharmacology of Tramadol focussing on the content  for the FRCA Primary exam. We explore its unique multi-mechanism analgesic action, pharmacokinetics, clinical uses, and key points.

Show notes at: https://gasgasgas.uk/tramadol-for-frca-primary-exam/

================================================

GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

In this episode of GasGasGas, we explore Alfentanil, a short-acting μ-opioid receptor agonist pivotal for anaesthetic practice. Discovered in 1976 by Janssen Pharmaceuticals, Alfentanil remains a super handy agent, especially for (modified) rapid-sequence inductions and acute pain management.

Show notes at https://gasgasgas.uk/alfentanil-for-the-frca-primary/ 

================================================

GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025

TIVA Models for Propofol particularly the: Marsh, Schnider, and Eleveld TCI models.

Avoid the classic pitfalls of blindly trusting a pump. If you’re prepping for the FRCA or just want to master the ‘why’ behind TCI behaviour, you’re in the right place. Sorry to the USA folks stuck with mcg/kg/min!

Show notes at: https://gasgasgas.uk/tiva-models-for-propofol/

================================================

GasGasGas - Covering Anaesthetic Science for Anaesthetists!

Sponsored by Teach Me Anaesthetics

Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]

Contributions to keep the lamps lit here

================================================

Dr Gas Lurks On: 

> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)

> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X

> FaceBook: Facebook - Gas Gas Gas

> Website: www.gasgasgas.uk

================================================

Disclaimer / Sage Advice

> All content is educational in nature and never intended to be acted upon.

> This information is not a suitable substitute for medical advice.

> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 

> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.

================================================

Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 

Sassy Jazzy - La Faena - Free music archive

================================================

"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."

© GasGasGas-Podcast 2025