Genefitletics

By Sushant Kumar

This podcast is hosted by biotech entrepreneur Sushant Kumar, Founder & CEO of Genefitletics. Through this exclusive health podcast, he addresses the information asymmetry in the preventive health... more

· Health & Fitness

Download on the App Store

Download on the App Store

Get it on Google Play

FAQs about Genefitletics:

How many episodes does Genefitletics have?

The podcast currently has 117 episodes available.

Genefitletics episodes:

February 15, 2024 Health Discourse with Sakshi & Sushant- Episode 7
Sexual health issues among male population, specifically, Erectile Dysfunction(ED), has become one of the major chronic health conditions with over 50% of male population in the age band of 40-70 years facing ED.
Research has found that men having obesity or suffering from type 2 diabetes &/or high blood pressure are at high risk of Erectile dysfunction. Besides, chronic stress can also lead to ED.
All these are interconnections with a common underlying cause- Nitric Oxide(NO) Deficiency.
NO is the most important gas produced inside our body which plays a key role in cellular communication, acts as vasodilator, regulates blood flow, oxygen uptake & delivery & facilitates insulin signalling.
Infact Erectile Dysfunction is caused by lack of vasodilation & blood flow attributed to NO deficiency
NO is produced through two pathways
-Endothelial Cell : ENOS, enzyme when coupled with Endothelial cell produces NO by metabolising L-arginine in presence of oxygen. L-arginine is a semi essential amino acid produced inside our body through the Urea Cycle. We do not need to consume excess L-arginine as it could activate Arginase Enzyme & NOS could produce Superoxide, causing oxidative stress. Oxidative stress, inflammation, high glycemic diet as well as oxidation of Tetrahydrobiopterin(BH4 to BH2) which uncouples ENOS, thereby shutting down NO production. As we age ENOS’s ability to produce NO reduces by 10% every year & therefore by the time we reaches age of 50, ENOS ability to produce reduces by 50% & therefore second pathway becomes more important
Oral microbiome triggers Nitrate-Nitrite-NO pathway: Microbes in our mouth can metabolise nitrate in green leafy vegetables into nitrite which when mixed with stomach acid produces NO. If your oral microbiome is imbalanced, it could reduce its ability to produce NO.
Certain lifestyle choices can disrupt NO production including use of mouthwash, Fluoride in toothpaste, processed foods & deficient sleep
If you think Supplements /Drugs such as Viagra, Ashwagandha & Shilajit could help in curing erectile dysfunction, you are in for the biggest shock.
Drugs such as Viagra is not a NO donor but is NO dependent. NO when produced activates a messenger cyclic GMP which is a vasodilator. Viagra makes sure that cGMP does not break down. However if your body is not producing NO, Viagra will never work as the substrate on the basis of which it functions is not activated. DO not fall for these supplements as they will never work if your body is not production NO.
Our today’s talk deep dive into role of NO & oral microbiome in Erectile Dysfunction.
...more
31min
February 12, 2024 Health Discourse with Sakshi & Sushant- Episode 6
Obesity is a global epidemic with more than a quarter of the population dealing with this metabolic syndromeWhile there are tens of thousands of solutions to suppress your weight/make you lose weight, 99% of them are band-aid solutions & do not focus on what makes you obese.
Those companies &/or coaches, it is a financial model! You need to maintain your weight, you need to pay them every month to subscribe to their fad diet solutions & working schedules/plans.
What causes Obesity? It is low grade chronic inflammation! So you must be wondering how inflammation in your intestines can make you gain weight? There is whole science behind & most of the biological decisions inside our body are driven by our microbiome.
You may blame energy metabolism & try to create that energy deficit by eating less & burning more but energy metabolism is not about this mathematical equation. There is a web of molecular features & pathways driven by interaction between your microbiome & external environment & nutrition choices.
These microbes impact/produce certain protein /hormones such as GLP-1, PYY Ghrelin & Leptin that impacts your satiety & hunger responses. While these are not the only pathways! There are multiple other interactions such as production of nitric oxide & expression of Nitric Oxide synthase that can impact your weight management & make you develop obesity
However, new age medical weight loss companies have made you believe that anti-obesity drugs such as GLP-1 receptor agonists can make you lose weight. This is far away from reality
-Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs
-Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help
-It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more.
In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression.
Today we discussed what could render GLP-1 drug ineffective.
We at Genefitletics measures each of these gut & oral microbiome pathways to understand the changes in biology & chemistry before & during disease onset & provide interventions to bring your body back into homeostasis position.
...more
31min
February 09, 2024 Health Discourse with Sakshi & Sushant- Episode 5
Exercise has a vital role to play in fine tuning our physiology & overall health. A moderate exercise with 60-75 minutes per day , 3-5 days a week is important for various biological processes including regulating satiety level, cardiovascular disease, stress response & more.
However, an important aspect is exercise performance. Right nutrition choices play a key role in improving skeletal muscle performance. However, in the name of nutrition, there are a number of supplements such as L-Arginine, Creatinine, Beta-alanine & more being sold.
However, do we really require supplements? If yes, how much, which supplement? What is the molecular /biological mechanism that makes sure the supplement confers the intended benefit? Can’t such food molecules come from foods? How those molecules are synthesised.
On the back of these pertinent questions, most fitness service providers miss the relevance of the most important gas produced inside our body every millisecond- Nitric Oxide. NO is a key molecule for various biological processes including metabolic health, cardiovascular health, sexual health, brain health & more. Without NO, you lose the cardiovascular benefits of exercise. NO is said to improve exercise performance, improve delivery of Oxygen & nutrients to working tissue & more.
There are two pathways which stimulates nitric oxide production
-Nitric Oxide Synthase(NOS): Endothelial cells line every blood vessel & via NOS facilitates production of NO. NOS converts L-Arginine in presence of oxygen into L-Citrulline & NO. NO is oxidised into nitrate which is stored in skeletal muscle where it gets converted into NO when required & elevates vasodilation effects, thereby improving exercise performance.
Consider this, most of these fitness companies would ask you to take L-arginine supplement which is the starting point of disaster. L-Arginine is a semi essential amino acid which our body itself produces. Excess L-Arginine production can lead to overexpression of Arginase Enzyme which competes with NOS for L-Arginine & therefore it is diverted & not put to use for NO production. Instead, it leads to production of superoxide which triggers oxidative stress. Besides, inflammation due to gut microbial dysbiosis can trigger endothelial cell dysfunction & reduces the ability to produce NO. However as we age, ability of our endothelial cells to produce nitric oxide reduces & therefore the second pathway becomes more important
-Oral microbiome: Microbes in our mouth that synthesise nitrate in various green vegetables into nitrite which mixes with stomach acid. A portion of nitrite is stored in various tissues including skeleton muscle where it is converted into NO.
Rather than just subscribing to supplements, you should understand your biology & functions your oral microbiome perform. Wrong oral hygiene practices such as Mouthwashes can imbalance your oral microbiome & impacts NO producing, thereby directly influencing your exercise performance.
Today we discuss the role of oral microbiome & gut microbiome in improving exercise performance.

Log on to www.genefitletics.com
...more
18min
February 07, 2024 Health Discourse with Sakshi & Sushant- Episode 4
Oral Illness continues to be a huge burden in India with more than 95% of Indians having dental caries & over 50% have periodontal diseases.
Most of the current set of dental interventions are band aid solutions resorting to root canals, tooth fillings & more but misses out the most important aspect- the microbes living inside our mouth- ORAL MICROBIOME. One of the important aspect that maintains a healthy oral microbiome is SALIVA
The current hygiene practices & oral products, which are meant to upkeep our oral health, are just doing the opposite
-Disrupting Oral Microbiome
-Impacting oral pH
-Interfering with remineralisation
One of the common ingredients found in most oral products- Fluoride , assumed to be safe, has been found to be a major culprit.
Fluoride is not naturally found in the body & is not biocompatible with our oral biology. If we look back, Decades ago, Fluoride was found to cause less cavities & we have seen dentistry recommending fluoride as a part of oral hygiene. It is not deficient Fluoride but excess Fluoride which is the major culprit.
Fluoride is an antiseptic, anti-microbial, neurotoxin & works against our oral microbiome. It has been found that Fluoride is said to impact our brain, IQ, thyroid functions, increase risk of arthritis & more. It has also been found that it is inversely related to melatonin levels & fluorosis is said to reduce our melatonin levels.
Besides, Fluoride is electron negative & therefore it is a strong oxidising agent & accepts electrons from other elements. As such Fluoride can combine with other minerals such as sodium ,Phosphate & can enter into every single tissue. In Fact it could interfere with every single cellular process & can even alter our metabolism
Fluoride is even said to make oral pH level acidic, creating an opportunity for opportunistic pathogens to grow & thrive. Besides, when consumed in excess amounts, it could replace Hydroxyapatite which is naturally found inside our body and is needed to remineralise our teeth.
Sadly most toothpastes & municipal water supply have a lot of Fluoride which is directly impacting not only our oral health but also triggering waves of systemic health issues.
Today we discussed at length on the role of Fluoride in impacting various biological processes inside the body. Worth listening.

Log on to www.genefitletics.com for more info.
...more
25min
February 05, 2024 Health Discourse with Sakshi & Sushant- Episode 3
100 million people in India are dealing with type 2 diabetes & counting!
India is called Diabetic capital of the world.
We have all science & technology & even healthcare to address range of chronic diseases including type 2 diabetes but still the number of Diabetic population seem to increase with current healthcare industry having no clue how to eradicate this epidemic
Do you know why? The industry is too much focussed on managing type 2 diabetes through generic nutrition & pharmaceutical approach rather than going deep down to understand & decode hard to detect signals & asymptomatic molecular targets involved in onset & progression of this metabolic syndrome
& now we have these new age health tech companies who are promoting diabetes reversal programs!Are these programs really worth it? Do they really reverse diabetes?
Answer to these questions is NO . More so as none of these companies address 99% of our biology epigenetically- our microbiome
It is important to understand the mechanics behind onset & progression of type 2 diabetes
Imbalanced biology triggered by gut /oral microbial dysbiosis creates a situation where first fasting insulin spikes, then fasting glucose spikes & finally Hba1c spikes. The focus has to be to prevent fasting insulin from spiking. If you are suppressing Hba1c or blood glucose levels, the damage has been done. You are just suppressing these plasma level biomarkers.
So what regulates insulin response. There are multiple molecules that come into play , produced both by gut & oral microbiome. The most important one that makes sure that glucose is not left in circulation & is transported into your cells for performing various biological processes is NITRIC OXIDE.
Nitric oxide is produced via two pathways
-Endothelial cells which line every single blood vessel. However our cells ability to produce NO reduces as we age.
Oral Microbiome Certain microbes synthesises nitrate into nitrite which is precursor for NO production
If you are not able to measure NO production & other relevant gut microbiome derived metabolites such as Butyrate, GLP-1, PYY, Fucose Pathway, LPS & more, you can never solve diabetes.

Just think over it. Do you want to manage a condition you already have or would like to understand what makes me/going to make me develop a disease & how I can eliminate the chemicals involved in the disease before the disease onset.

Listen to the complete episode
...more
32min
February 02, 2024 Health Discourse with Sakshi & Sushant- Episode 2
Solving & finding the underlying cause why people develop metabolic disease trilogy- Type 2 diabetes-Cardiovascular Diseases- Chronic Kidney Disease has been a nightmare.
More so as our modern healthcare system, treat all three diseases separately & treat separate organs.
What if all these three diseases are connected? Why are our healthcare professionals missing out on this?
Why we just end up managing these diseases which becomes more dangerous given the fact that they are silent killers
With 10% of the Indian population dealing with CKD, cardiovascular disease number one killer & 100 million people dealing with diabetes, why do we not have a solution?
Can we just manage them through pharmaceutical interventions, tracking plasma level markers through blood works, fad diets, & endless dialysis sessions?
What if it roots from the most neglected organs- Gut & Oral microbiome?
As year 2023 comes to close , we decode the interconnection between these 3 diseases & how oral & gut microbial sub optimal functions triggers onset & progression of type 2 diabetes, Chronic Kidney Disease & Cardiovascular disease.
While you could listen to this exciting conversation, summary of few molecular signals involved in develop of these diseases
- Low Nitric Oxide production caused by inflammation, oxidative stress, decreased transport of L-arginine to endothelial cells, increased circulatory level of NO inhibitor- ADMA & oxidation of NOS cofactor tetrahydrobiopterin
-Competition between NOS & Arginase for L-arginine in case of excess L-arginine supplementation which makes Arginase trigger oxidative stress.
-Elevated TMAO, LPS, p-Cresol & Indoxyl Sulphate levels released by gut microbiome
& more,
Log on to www.genefitletics.com

...more
32min
December 22, 2023 Health Discourse with Sushant & Sakshi- Episode 1
When it comes to chronic diseases, we are living in the dark. We do not know how it developed, why it developed & if someone develops a chronic disease say diabetes, cardiovascular disease, depression or more, he/she blames it on bad genes or bad luck.
Well it's not bad genes or bad luck, it's some change in biology + chemistry going on before & during the onset & progression of chronic diseases which our modern healthcare system has still not understood.
Trillions of $ have been spent on making pharmaceuticals that can manage the disease we already have, rather than investing in application of science & technology to understand the pathogenic process involved in a range of chronic diseases.
While, it is no brainer that nutrition by far is the most important determinant of health & disease, science behind nutrition has still not been understood. The fallacy in adopting nutrition choices is driven by three major factors
-Nutrition choices are driven by population studies that assume that every individual is average, which is not the case. Everyone has 95% unique biochemical individuality which is driven by functions of the microbiome. Unfortunately, these population studies does not take into account uniqueness of our biology
-Nutrition choices/plan carved out by nutritionists & coaches is driven by anecdotal evidence, guess work & belief systems which misses out evaluating biochemical functions of each individual.
-Health influencers, VC funded disease management & fitness companies that promote fad diets such as high protein, low carb, atkins, ketosis etc without any scientific evidence & assuming it is beneficial for everyone. If these diets would have worked, we would as a society have overcome diseases such as type 2 diabetes.
-. When it comes to scientific data, the vast majority of food and supplement research does not account for the specific and unique contributions of an individual’s microbiome.
This is where Genefitletics comes in- we have adopted a data driven approach towards precision nutrition driven by tech + computational biology which measures molecular data aka chemistry from human microbiome-oral, gut & vaginal & analyse it using mathematics. Our system biology + maths platform convert molecular data & features into biology pathways that determines which food substrates we should feed
We open our platform as our founder Sushant Kumar & co-founder Sakshi Balideep dive into science behind precision nutrition. Worth spending 30 minutes on this exciting talk.

Log on to www.genefitletics.com for more information.

...more
36min
September 22, 2023 Say YES to Nitric Oxide & NO to supplements | Myths behind supplements busted
Post COVID, people have become conscious of their health & are looking for solutions that can help them regulate their biology.
However, this has been considered as an opportunity with a number of supplements & nutraceutical companies who have been offering standard OTC supplements- vitamin, mineral, prebiotics, probiotics, synbiotics & more for worse.
The marketing gimmicks used by these companies be it obnoxious claims or using celebrities for promoting are making people fall for it & pushing themselves towards a deep well of chronic diseases. The few things which are important to consider
-These companies assume that OTC supplements having standard ingredients will work for everyone
-They fail to assume each individual’s unique biology is as unique as their fingerprint.
-Most of these are in powdered form which does not confer health benefit as these powder cannot pass through a highly acidic environment in stomach, bile acid or digestive enzymes & even face colonisation resistance in the gut.
-They fail to consider encapsulation techniques which can survive these hostile environments inside our body.
MOST IMPORTANT these supplements have non nutritive or artificial sweeteners such as Sucralose, Sorbitol & more which science has shown can cause Oxidative stress & inhibit nitric oxide production
This nitric oxide is one the most beneficial molecules that is produced inside our body via L-arginine metabolism by NOS enzyme & nitrate metabolism by oral microbiome into nitrite.
This nitric oxide regulate our blood flow, increases its circulation & is said to play a key role in
Nutrient & oxygen delivery to cells
-Regulates blood pressure
-Improves insulin sensitivity
-Improves sexual health -both male & female
-Improves brain health & memory
-Protect from pathogens
-Prevent from plaque build up
-Make arteries flexible & less stiff & rigid
-Excrete toxins
-Mitochondrial Respiration through regulating electron transport chain mechanism
These supplements are going to suppress your ability to produce nitric oxide & make you develop a host of chronic diseases- diabetes, cardiovascular diseases, dementia & more.
Today's talk discusses the science of nitric oxide & how these OTC supplements are going to make you develop these diseases. A MUST WATCH
Video available https://www.youtube.com/watch?v=Cupks7Hf8fk
More details at www.genefitletics.com
...more
29min
September 15, 2023 Oral + Gut Microbiome & Colon Cancer- Interview with Dr Amine ZORGANI
Incidence of cancer is increasing & around 13% of the Indian population is at high risk of developing cancer with more representation from younger population.
It is one of the most complex diseases & the current set of interventions are just on suppressing tumours through modern medicine methods- chemotherapy, immunotherapy, surgery & more with limited success.
Currently resources are scarcely deployed to understanding the onset & progression of various forms of cancer.
Oncology is poised to see a lot of innovation with a number of startups entering this space to address cancer care. However, we still have to innovate in finding molecular signatures way before cancer develops. We started studying molecular interactions for autoimmune diseases, diabetes & more & we are now extending our knowledge footprint to cancer.
Among various forms of cancer, Colon cancer is the top three most common cancer & second leading cause of cancer deaths worldwide
Research has now found that trillions of microorganisms living in our mouth & gut have a role to play in onset & progression of cancer. When it comes to colon cancer, the oral & gut microbiome potentially can develop cancer through their interaction with the human host. Altered gene expression of these oral & gut microbes can lead to production of harmful toxins such as LPS & overexpression of human genes & over activeness of certain proinflammatory molecules such as cytokines, TLR-2 & more.
Some of pathogenic microbes living in the mouth such as Fusobacterium Nucleatum & P GIngivalis can actually alter the composition & functions of gut microbiome & lead to development of cancer. Similarly pro- inflammatory responses of certain microbes in the gut such as E. Facelias, E Coli & Peptostreptococcus are also one of potential causes of colon cancer.
We had a great insightful & thought provoking discussion with Dr.Amine on the connection between oral & gut microbiome & cancer. This is a must listen talk.
Thank you Dr.Amine for shedding light on this concerning topic. I am sure many people will benefit from your insight.
Log on to www.genefitletics.com to know how gut microbiome & oral microbiome could work in your favour.
...more
27min
September 05, 2023 What if your spit could talk?
We recently launched India's first oral microbiome genes expression solution which encompasses molecular insights into dental health, sexual health, reproductive health, metabolic health, brain & cognitive health, heart health & more.
The microbes living in the mouth, the second largest colonised area for microbes after the gut, have been ignored for long.
Our hygiene( including choice of toothpaste & mouthwash), dental practices, environment & above all nutrition choices impacts oral microbial functions. Oral microbial dysbiosis or microbes performing sub optimal activities can trigger a biological war inside your mouth & makes the immune system trigger inflammation. This can lead to inflammation inside the mouth & even allow microbes in the mouth such as P. Gingivalis, S.Mutans & more to translocate to other areas inside your body where do not belong & can trigger inflammatory activities & production of harmful metabolites- leading to systemic inflammation & number of health issues such as Alzhimers, hypertension, heart disease, type 2 diabetes, obesity, erectile dysfunction, reproductive health & more
During our today’ discussion on “ WHAT IF YOUR SPIT COULD TALK”, we discussed every single aspect of the role of the oral microbiome in your oral health & how it impacts systemic & overall health.
Our oral microbiome solution- ORAHYG is live now & we have already started dispatching our kits. We are offering an additional discount of Rs.2,500 on a 6 months subscription( this is available for the first 20 kits). Do not wait any further- Nourish your oral microbiome with us : https://genefitletics.com/orahyg/
...more
29min

FAQs about Genefitletics:

How many episodes does Genefitletics have?

The podcast currently has 117 episodes available.

More shows like Genefitletics

Neurocritical Care Society Podcast by Neurocritical Care Society

Neurocritical Care Society Podcast

47 Listeners