General Medicine and Primary Care

Host: Ivy Ka Man Law, PhD

A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice

Marina Liso, Stefania De Santis, Giulio Verna, Manuela Dicarlo, Maria Calasso, Angelo Santino, Isabella Gigante, Rajaraman Eri, Sathuwarman Raveenthiraraj, Anastasia Sobolewski, Valeria Palmitessa, Antonio Lippolis, Mauro Mastronardi, Raffaele Armentano, Grazia Serino, Maria De Angelis, Marcello Chieppa

Background: Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is a multifactorial disorder characterized by chronic inflammation and altered gut barrier function. Dysbiosis, a condition defined by dysregulation of the gut microbiome, has been reported in patients with IBD and in experimental models of colitis. Although several factors have been implicated in directly affecting gut microbial composition, the genetic determinants impacting intestinal dysbiosis in IBD remain relatively unknown.

Methods: We compared the microbiome of normal, uninflamed wild-type (WT) mice with that of a murine model of UC (ie, Winnie strain). Winnie mice possess a missense mutation in Muc2 that manifests in altered mucus production as early as 4 weeks of …

Host: Kathy King, RDN

Guest: Teresa Pangan, PhD, RDN

Joining Kathy King to discuss the possible benefits and precautions of using supplemental doses of vitamin D to help fight COVID-19 is Dr. Teresa Pangan, a registered dietitian, health counselor, and keynote speaker.

Host: Charles Turck, PharmD, BCPS, BCCCP

To give us a better look into how counties and cities across the nation are reacting to the racial disparities in healthcare that were brought into the limelight by the COVID-19 pandemic, Dr. Charles Turck reviews the declaration made by officials in Ohio’s most populated county that racism is a public health crisis.

Host: Charles Turck, PharmD, BCPS, BCCCP

To find out how different racial and ethnic groups are being affected by the COVID-19 pandemic, Dr. Charles Turck joins us to analyze data that was collected by the COVID Racial Tracker.

Published July 24, 2020

Host: Abdullah Abdussalam, MD

Proactive Vs Reactive Therapeutic Drug Monitoring of Infliximab in Crohn’s

Diana M Negoescu, Eva A Enns, PhD, Brooke Swanhorst, Bonnie Baumgartner, James P Campbell, Mark T Osterman, MD, Konstantinos Papamichael, PhD, Adam S Cheifetz, MD, Byron P Vaughn, MD

Background: Therapeutic drug monitoring (TDM) is increasingly performed for Infliximab (IFX) in patients with Crohn's disease (CD). Reactive TDM is a cost-effective strategy to empiric IFX dose escalation. The cost-effectiveness of proactive TDM is unknown. The aim of this study is to assess the cost-effectiveness of proactive vs reactive TDM in a simulated population of CD patients on IFX.

Methods: We developed a stochastic simulation model of CD patients on IFX and evaluated the expected health costs and outcomes of a proactive TDM strategy compared with a reactive strategy. The proactive strategy measured IFX concentration and antibody status every 6 months, or at the time of a flare, and dosed IFX to a therapeutic window. The reactive strategy only did so at the time of a flare.

Results: The proactive strategy led to fewer flares than the …

Host: Jennifer Caudle, DO

Guest: Kathleen Blake, MD, MPH

Guest: Peggy Chen, MD

Behavioral health integration has proven to be an effective solution to improving access to treatment for many mental health conditions… So why is it not more prevalent in the medical community? Joining Dr. Jennifer Caudle to dive into the findings and implications of the joint AMA-RAND Corporation study recently published in the Annals of Internal Medicine are Dr. Kathleen Blake with the AMA and Dr. Peggy Chen from the RAND Corporation.

And, click here to listen to a conversation regarding Behavioral Health Integration and its effect on clinical practice.

Guest: Gregory J Kubicek, MD

When caring for patients who are at greater risk of complications from COVID-19, what extra precautions are needed to help keep them safe and healthy? That’s what staff radiation oncologist Dr. Gregory Kubicek from the MD Anderson Cooper Cancer Center shares with us.

Published June 23, 2020

Guest: Michael Greenberg, MD

The chaos and uncertainty brought on by the COVID-19 pandemic may make us forget the simple actions we can all do to connect with others and make the world a better place. Listen in as Dr. Michael Greenberg shares three of those simple actions.

Published June 15, 2020

Host: Jennifer Shu, MD, FAAP

Since the COVID-19 pandemic began, children have adjusted their schedules and way of living like everyone else, but what effects has this massive shift had on our young patients? That’s the question Dr. Jennifer Shu is here to answer.

Published June 12, 2020

Guest: Jennifer Shu, MD, FAAP

Tune in to hear Dr. Jennifer Shu describe what her life as a pediatrician is now like due to the COVID-19 pandemic and the steps she has taken to keep her patients and colleagues healthy.

Published June 12, 2020