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Welcome to the latest Series of Supportive Care Matters, a podcast hosted by Medical Oncologist and International Cancer Survivorship Expert, Professor Bogda Koczwara AM.

"If it were a pill, we would all want it." This powerful opening statement captures the essence of ground-breaking research that's transforming our understanding of cancer survivorship care. The CHALLENGE Study has delivered what many considered impossible: definitive evidence that structured exercise significantly extends the lives of colorectal cancer survivors.

The results are nothing short of remarkable. Colorectal cancer patients who participated in a structured exercise program for three years after completing surgery and chemotherapy showed an 80% disease-free survival rate at five years, compared to 74% in those who received only health education materials. The results showed that structured exercise provides a significantly longer disease-free survival. Even more impressive, overall survival improved from 83% to 90% - a 37% decrease in risk. To put this in perspective, for every 14 patients who followed the exercise program, one additional life was saved.

What makes this intervention unique is its sophisticated approach to behaviour change. Participants received individualised exercise prescriptions targeting 150 minutes of moderate aerobic activity weekly, combined with regular supervision and motivational support. Exercise physiologists conducted environmental scans to identify accessible opportunities, established accountability through regular check-ins and helped participants overcome barriers to physical activity. This wasn't simply about telling people to exercise - it was about teaching them how to make sustainable lifestyle changes.

The implications for clinical practice are profound. To discuss this ground-breaking paper in detail, Professor Bogda Koczwara is joined by the Australian Principal Investigators - Professor Haryana Dhillon and Professor Janette Vardy.

Visit www.oncologynews.com.au for show notes and more information about Supportive Care Matters.

This conversation is proudly produced by the Podcast Team at The Oncology Podcast, part of the Oncology Media Group Australia.