In this podcast, we unravel the intricacies of thyroid function and delve into the complexities of hypothyroidism, a condition marked by insufficient thyroid hormone production. The thyroid gland, nestled in the neck and resembling a butterfly, plays a pivotal role in regulating metabolic processes through the synthesis and release of hormones such as thyroxine (T4) and triiodothyronine (T3). Hypothyroidism, with its diverse etiologies including autoimmune thyroiditis and iodine deficiency, poses significant health challenges, manifesting in symptoms ranging from fatigue to cardiovascular complications. While levothyroxine remains the cornerstone of treatment, adjunctive therapies such as T3 supplementation and desiccated thyroid extract like Armour Thyroid are being explored to address persistent symptoms and optimize patient outcomes.

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References:
Biondi, B., & Wartofsky, L. (2014). Treatment with thyroid hormone. Endocrine reviews, 35(3), 433-512. https://academic.oup.com/edrv/article/35/3/433/2354656

Boucai. L., (2024). Overview of thyroid function. Merck Manual, Professional Version. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/thyroid-disorders/hypothyroidism

Boucai. L., (2024). Hypothyroidism. Merck Manual, Professional Version. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/thyroid-disorders/hypothyroidism

Hegedüs, L., Bianco, A. C., Jonklaas, J., Pearce, S. H., Weetman, A. P., & Perros, P. (2022). Primary hypothyroidism and quality of life. Nature Reviews Endocrinology, 18(4), 230-242. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930682/

Wyne, K. L., Nair, L., Schneiderman, C. P., Pinsky, B., Antunez Flores, O., Guo, D., ... & Tessnow, A. H. (2023). Hypothyroidism prevalence in the United States: a retrospective study combining national health and nutrition examination survey and claims data, 2009–2019. Journal of the Endocrine Society, 7(1), bvac172. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706417/