This is Episode 04: Esophagus Part 3: The Dose Escalation & Adjuvant IO Debates.In our last episode, we laid the foundation with the landmark trials establishing neoadjuvant and definitive chemoradiation. But a key principle in oncology is to always ask: can we do better? Today, we tackle the controversies and innovations that have attempted to improve upon those standards. We’ll dissect the decades-long, and largely disappointing, quest for dose escalation. Then, we’ll pivot to the modern era and explore how adjuvant immunotherapy is revolutionizing outcomes.