In this episode of GI101, host Dr. Christina G. Gonzales, DMSc, MPAS, PA-C, reviews Zollinger-Ellison Syndrome (ZES), a rare disorder caused by gastrin-secreting tumors (gastrinomas) that lead to excessive gastric acid production. You’ll learn how ZES presents with refractory peptic ulcers, chronic diarrhea, and abdominal pain, understand its association with MEN1, and review diagnostic testing such as fasting gastrin levels and secretin stimulation testing. We’ll also cover imaging strategies to localize gastrinomas and management approaches, including acid suppression and surgical resection.
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