Giants Shoulder

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqe

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulder

Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

Kirsten Cherian is the Stanford neuropsychologist who gave Special Forces veterans with traumatic brain injuries a single dose of ibogaine — a psychedelic root used in African shamanic ritual for millennia — and watched their injury scores collapse from severe to normal in a month. It's a weak agonist for nearly every receptor in the body, yet it somehow delivers a tailor-made result to each person — a form of pharmacology science has never seen before.

Expect to learn why veteran suicide outpaces combat deaths, how one dose collapsed PTSD, depression, and anxiety at once, why users describe their brains being "defragged," a researcher's 12-hour "conversation" with the ibogaine molecule itself, the bizarre phenomenon of "DMT blocking" by hostile entities, why ibogaine has no single receptor target — "matrix pharmacology," how brain age dropped by over a year in a single month, and why the results contradict science's leading theory of consciousness.

Timestamps

0:00:00 Trailer

0:02:11 How This Ibogaine Study For Veterans Began

0:04:06 Veteran Suicide Now Outpaces Combat Deaths

0:07:31 The 30-Veteran Study With Staggering Effect Sizes

0:12:22 Ibogaine Isn't A Trip, It's A Waking Dream

0:13:14 Vivid Trip Imagery: Slideshows And "Defragged" Brains

0:15:02 Reconciling Trauma By Talking To The Dead

0:20:01 What A Bad Ibogaine Trip Actually Looks Like

0:24:50 Purging "Black Demons" In A Room Full Of Strangers

0:27:23 The Scientist Who Talked To The Ibogaine Molecule

0:33:36 Why Elite Special Forces Veterans Still Broke

0:34:30 DMT Blocking: When Entities Refuse To Let You In

0:41:22 The Psilocybin Researcher Who Believes In Telepathy

0:43:00 Why Ibogaine Has No Single Target In The Brain

0:46:25 The 1920s Thought Experiment That Proves We're Too Skeptical

0:49:38 Ibogaine As A Full-System Diagnostic, Not A Drug

1:03:36 Measurable Brain Change From An African Tree Fruit

1:05:19 Brain Age Dropped Over A Year After One Dose

1:17:21 The Finding That Contradicts The Leading Theory Of Consciousness

1:20:28 If Ibogaine Research Got A Blank Billion-Dollar Check

1:23:21 Could Ibogaine Help Parkinson's And ALS Patients?

... Email for sponsorship enquiries: [email protected]

GS Episodes Mentioned

Dalibor Sames — Meet The Greatest Ibogaine Psychedelic Scientist You've Never Heard Of: https://www.youtube.com/watch?v=K9whp_wtCoc

Andrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDA

David Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5o

Matthew Johnson — Consciousness Expert Explains The 5 Levels Of The Psilocybin Experience: https://www.youtube.com/watch?v=FHyy3aW09sk

Robin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://youtu.be/t-GkE4YtLRk

Guest LinksStanford Profile: https://profiles.stanford.edu/kirsten-cherian

Stanford Brain Stimulation Lab: https://bsl.stanford.edu/

MISTIC Study (Nature Medicine, 2024): https://pubmed.ncbi.nlm.nih.gov/38182784/

ResearchGate: https://www.researchgate.net/profile/Kirsten-Cherian

VETS — Veterans Exploring Treatment Solutions: https://vetsolutions.org/

Download the most scientifically rigorous nutrition app MacroFactor!

Use code GIANTS for a 2 week FREE trial: https://app.macrofactor.com/mfgiants

Try Mind Lab Pro, The Universal Nootropic For A Sharper Brain: https://www.mindlabpro.com/?a_aid=67fd1cb8d9ad3&a_bid=6d45f5c3

Andrés Gómez Emilsson is a consciousness mathematician at the Qualia Research Institute, and he's back for round two of ranking altered states of consciousness by sheer intensity. He and Evan spend two hours ranking every substance and practice they can think of — arguing that ibogaine may be the most ethically urgent drug on Earth, that a hardcore meditation retreat can rival 5-MeO-DMT, and that an obscure nootropic produces psychedelic visuals through a mechanism nobody understands.

Expect to learn why ibogaine seems to "scan" your whole nervous system instead of hitting one receptor, how advanced jhana meditation can go toe-to-toe with 5-MeO-DMT in depth, why ordinary DMT produces far more alien entity encounters than its "stronger" cousin, the topology behind why feeling like God and feeling like there's no self are almost the same state, why cannabis's real danger isn't addiction but a specific schizophrenia risk in young men, how combining LSD and ketamine produces "freewheeling hallucinations" you can consciously direct, why mescaline might be the best nootropic for doing actual math yet never caught on, and where MDMA, salvia, and a little-known nootropic called coluracetam land on the scale, and much more…

Timestamps

0:02:53 Ibogaine

0:17:28 5-MeO-DMT

0:36:05 Meditation

0:46:33 DMT

0:58:41 Cannabis

1:05:15 Psilocybin

1:11:41 Ayahuasca

1:18:42 Coluracetam

1:21:09 MDMA

1:29:26 Salvia

1:44:21 Ketamine

1:54:37 Mescaline

1:58:48 LSD......

Email for sponsorship enquiries: [email protected]

Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

GS Episodes Mentioned

David Nutt — Neuroscientist Ranks Every Drug By How Hard They Are to Quit! Tier List Part 2: https://www.youtube.com/watch?v=CEgbv6IHYaYMichael

Levin & Earl Miller — Platonic Space of Minds, Bioelectricity, Cell Intelligence & Neurobots: https://www.youtube.com/watch?v=6mU5nN5nlLA

Guest Links

Qualia Research Institute: https://qri.org

Qualia Computing (blog): https://qualiacomputing.com

Substack: https://andrsgmezemilsson.substack.com

X (Twitter): https://x.com/algekalipso

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulder

Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

Dr. Reshanne Reeder is a cognitive neuroscientist at the University of Liverpool and creator of the Ganzflicker — a flickering screen that makes most people hallucinate complex scenes within a minute, no drugs required. Her research suggests hallucinations themselves are just disordered mental imagery, and that the most vividly imaginative among us may be the closest normal-range group to a psychotic break.

Expect to learn why a simple red-and-black flicker makes most people hallucinate faces and landscapes within a minute, the accidental lab discovery that led to the Ganzflicker experiment, why she believes hallucinations are simply "disordered mental imagery," why psychedelic and clinical hallucinations come from entirely different brain mechanisms, the 1960s art device built to replace the television, why almost nobody hallucinates their own phone, how aphantasia may carry a hidden cost to face recognition, how she's trying to predict psychosis risk years before it ever develops, and much more…

Timestamps

0:00:00 Trailer

0:02:29 How She Discovered Imagery Isn't One Thing

0:08:43 Can You Decode Images in an Aphantasic's Brain?

0:10:37 The Truth About "Unconscious" Mental Imagery

0:16:01 Imagery vs Imagination: Why They Aren't the Same Word

0:18:55 Imagery, Perception, Hallucination, Dreaming: Where's the Line?

0:20:36 The Hyperphantasics Who Project Images Into the Real World

0:22:23 Her Bold Claim: Hallucinations Are Disordered Imagery

0:23:37 Can Aphantasics Hallucinate on Psychedelics?

0:27:55 The DMT Study Where 90% Said It Felt More Real Than Reality

0:29:39 Why Mental Imagery Breaks the Predictive Brain Theory

0:32:21 The Irish Castle Test: Are Mental Images Just Priors?

0:38:58 She Made People See Faces in Pure Random Noise

0:42:04 The Illusion That Turns Faces Into Monsters

0:45:48 Why Aphantasia Might Come With a Face-Recognition Cost

0:47:35 His Sister Went 31 Years Without Knowing She Had Aphantasia

0:49:59 The Accidental Origin Story of Ganzflicker

0:51:26 The 1700s Origin of the "Whole Field" Hallucination Effect

0:57:41 "I See a Lighthouse": The Moment Ganzflicker Was Born

1:00:28 Why Aphantasics Barely Hallucinate on Ganzflicker

1:05:31 The Sharp Cliff Between Zero and Weak Mental Imagery

1:12:30 Why Nobody Hallucinates Their Phone

1:19:45 The Hypnosis Session That Left His Arm Frozen in the Air

1:22:13 The 1960s "Dream Machine" That Was Supposed to Replace TV

1:35:59 Can This Predict Psychosis Before It Happens?

...

... Email for sponsorship enquiries: [email protected]

GS Episodes Mentioned

Adam Zeman — The Blind Mind's Eye: How Aphantasia Is Rewriting Consciousness ! Dr Adam Zeman: https://www.youtube.com/watch?v=SgA2up6-Bok

Alfredo Spagna — Meet The Neuroscientist Proving We Got Imagination & Aphantasia WRONG!: https://www.youtube.com/watch?v=k8SBHefDnEk

David Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5o

Karl Friston — Meet The Neuroscientist Who Created The Best Universal Theory Of Brain Function: https://www.youtube.com/watch?v=R-IZOFs4qmY

Anil Seth — No. 1 Consciousness Expert: Optical Illusions that Prove Reality is a Lie, Emotions, Books and AI!: https://www.youtube.com/watch?v=lOSA06K0l1o

Guest Links

University of Liverpool Faculty Page: https://www.liverpool.ac.uk/people/reshanne-reeder

Personal Website (Ganzflicker Demo): https://www.reshannereeder.com/

Bluesky: https://bsky.app/profile/kerblooee.bsky.social

Google Scholar: https://scholar.google.com/citations?hl=en&user=DfdUB3UAAAAJ

LinkedIn: https://uk.linkedin.com/in/reshanne-reeder-53182123b

Check out Scispace: (JNGIANT35: Get 35% off on the Max plan) https://scispace.com/?via=jun1giantshoulder

Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

David Resnik is the NIH's Senior Advisor for Research Integrity and a philosopher of science who has spent his career defending careful, sober naturalism. He just co-authored a paper with biologist Michael Levin arguing that the shape of your body — and maybe your mind — is pulled from a nonphysical space of mathematical forms.

Expect to learn why cicadas evolved to emerge only in prime-numbered years to dodge predators, why a mule's infertility comes down to simple odd-and-even chromosome math, why mathematics might be a "free lunch" baked into the universe rather than something we invented, why there may be no real difference between an electron and the equation that describes it, why Michael Levin's leap to calling certain mathematical forms "minds" might be the biggest jump in modern biology, why a Xenobot growing eyes and ears it doesn't need raises the question of where biological information actually comes from, why even a few lines of sorting-algorithm code can behave in ways nobody predicted, and why David thinks it might not matter whether Platonism is literally true, as long as it keeps producing good science.

Timestamps

0:00:00 Trailer

0:02:52 Is Math Discovered or Invented?

0:15:48 Why Cicadas Emerge in Prime-Numbered Years

0:19:45 Why Mules Can't Reproduce (It's Just Math)

0:21:19 Michael Levin's "Free Lunch": Math That Isn't Physical

0:24:16 Is Materialism Actually Incomplete?

0:29:43 Xenobots: Where Did the Information Come From?

0:35:08 Why Do Xenobots Grow Ears and Eyes They Don't Need?

0:43:40 The Magnet and Iron Filings Experiment

0:45:26 Is There Really a Difference Between an Electron and Math?

0:46:40 Michael Levin's "Grand Canyon Jump" to Platonic Minds

0:48:03 What Is a Cognitive Light Cone?

0:54:26 Cutting a Triangle: What "Ingression" Actually Means

0:59:40 Michael Levin's Biological Compiler Idea

1:01:27 The Two-Headed Worm and the Eye That Shouldn't Exist

1:02:02 A Sorting Algorithm That Does the Unexpected

1:05:17 Laplace's Demon and the Limits of Prediction

1:09:43 Does It Matter If Platonic Space Is Real?

1:16:00 Could AI Access Minds Human Brains Can't?

1:17:36 The Limits of Any Mind in the Universe

... Email for sponsorship enquiries: [email protected]

GS Episodes Mentioned

Michael Levin — Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://youtu.be/LTBZRVKUwyM

Michael Levin & Earl Miller — Meet the Scientist Showing Every Cell In Your Body is Conscious!: https://youtu.be/eNi-_2cOVtc

Julian Barbour — Meet The Greatest Mathematician You've Never Heard Of: https://youtu.be/LcYdhjcFnzA

Guest Links

David Resnik — NIH Office of Intramural Research: https://oir.nih.gov/about/leadership-staff/david-resnik

Levin & Resnik — "Mind Everywhere" Part One (Biological Theory): https://doi.org/10.1007/s13752-025-00523-6

Levin & Resnik — "Mind Everywhere" Part Two (Biological Theory): https://doi.org/10.1007/s13752-025-00524-5

David Resnik — ResearchGate: https://www.researchgate.net/profile/David-Resnik-2

David Resnik — NIEHS Bioethics: https://www.niehs.nih.gov/research/resources/bioethics/bioethicist

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulder

Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

Elliot Murphy is a neurolinguist at UTHealth Houston who records language directly from inside the human brain, placing electrodes deep in the cortex of epilepsy patients and watching meaning get built in real time. His claim is unsettling: every time you speak, your brain performs an operation no other cognitive system — and no AI — can do, and the structure of grammar may be something the brain discovers rather than invents.Expect to learn why the phrase "old men and women" proves language breaks the laws of algebra, how "red boat" and "barco rojo" hide the same secret structure, what it means to record single words forming inside a living brain, why the deepest things you feel are impossible to put into words, how one word like "lunch" can be food, an event, and a time all at once, where Elliot stands on Michael Levin's idea that meaning lives in a Platonic space, why he thinks large language models don't understand a word they produce, what really separates human intelligence from pattern-matching, and much more…

Timestamps

0:00:00 Trailer

0:01:56 From Liverpool Bookworm to Brain Scientist

0:10:25 The Phrase That Breaks the Laws of Logic

0:12:36 Why "Red Boat" and "Barco Rojo" Are Secretly Identical

0:15:14 Where Language Actually Lives in Your Brain

0:20:02 Recording Single Words Inside a Living Brain

0:23:38 The Surgery That Changed How We Study Language

0:36:12 Does Anything Else Work Like Language? Even Music?

0:40:28 The Feelings No Words Can Ever Reach

0:42:19 The Nietzsche Line Elliot Can't Shake

0:44:52 How "Lunch" Is Three Contradictory Things at Once

0:57:47 Does Meaning Have a Mathematical Shape?

1:03:34 Is Grammar Invented — or Discovered in a Platonic Space?

1:13:54 What Even Is Agency?

1:25:00 What Actually Separates You From an AI

1:30:12 Where to Start With Nietzsche and Dostoevsky...

Email for sponsorship enquiries: [email protected]

GS Episodes Mentioned

Michael Levin — Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://www.youtube.com/watch?v=LTBZRVKUwyM

Michael Levin & Earl Miller — Meet the Scientist Showing Every Cell In Your Body is Conscious!: https://www.youtube.com/watch?v=eNi-_2cOVtc

Guest Links

Elliot Murphy — Website: https://elliot-murphy.com

Elliot Murphy — Google Scholar: https://scholar.google.co.uk/citations?user=4AYNRj0AAAAJ

Elliot Murphy — UTHealth Profile: https://www.uth.edu/people/profile?id=a676259c-6b83-45de-bba3-f9ce464344a6

Try Mind Lab Pro, The Universal Nootropic For A Sharper Brain: https://www.mindlabpro.com/?a_aid=67fd1cb8d9ad3&a_bid=6d45f5c3Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutAdam Butler is a DMT researcher and author who has taken the molecule over 100 times and completed the same Monroe Institute consciousness program the CIA funded during the Cold War. He went from suicidal alcoholic to sober and mission-driven through a molecule his own brain already produces -- and then, one day, found himself completely locked out of the DMT space with zero pharmacological explanation for why.Expect to learn why DMT stops working for some people with no pharmacological explanation for it, how the body produces its own DMT internally, what the Monroe Institute's Hemi-Sync binaural beats protocol has in common with a DMT trip without any substance at all, why a declassified CIA-linked report took remote viewing seriously enough to fund it for decades, what DMT entities actually look like across 100+ trips, the controversial DMT laser experiment that claims to reveal a rigid code-like grid in the visual field, why effect sizes in psychedelic-assisted therapy trials are becoming impossible to ignore, and much more…Timestamps0:00:00 Trailer0:02:17 Who Is Adam Butler? From Rock Bottom to a Mission0:07:18 The Story That Changed Everything0:13:21 Inside His First DMT Session0:24:22 Why DMT Doesn't Build Tolerance0:31:56 Blocked: The Night DMT Just Stopped Working0:38:22 The Telepathy Tapes and the DMT Laser Experiment0:40:38 Huxley's Reducing Valve and the DMT "Cheat Code"0:44:29 What Is a DMT Entity, Really?0:48:21 Jesters, Mantis Beings, and the Entity Portfolio0:54:48 Carhart-Harris's Theory vs Alien World-Building1:02:52 Do DMT Entities Have Their Own Agency?1:09:20 The Mantis "Technicians" and the Body Upgrade1:11:23 Meeting His Future Self on DMT1:17:28 Inside the Monroe Institute1:32:17 The Declassified CIA Gateway Project1:41:10 Temporal Lobe Epilepsy and DMT-Like States1:44:27 The DMT Laser Experiment Explained1:53:21 Debating the "Code of the Simulation" Claim1:58:37 Near-Death Experience and Why It All Matters... Email for sponsorship enquiries: [email protected] Episodes Mentioned:Robin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://youtu.be/t-GkE4YtLRkAndrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDAAndrés Gómez Emilsson — Consciousness Expert Explains The 6 Levels Of The DMT Experience: https://youtu.be/xMdl7zF2MWEGuest Links:Instagram: https://www.instagram.com/booksbyadambutlerYouTube: https://www.youtube.com/@ButlersDMTFieldGuidePatreon: https://www.patreon.com/BooksByAdamButlerBook — Butler's DMT Field Guide: https://www.amazon.com/dp/196050505XBook — Butler's Psychedelic Integration Field Guide: https://www.amazon.com/dp/B0H4GL8H6V...Email for sponsorship enquiries: [email protected]

Download the most scientifically rigorous nutrition app MacroFactor!

Use code GIANTS for a 2 week FREE trial: https://onelink.to/giants

Get Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10Want a full breakdown of your own conscious inner experience?

Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

Dalibor Sames is the chemist who reverse-engineered ibogaine into a version that appears to erase heroin addiction in a single dose, without the cardiac risk that can kill people on the original drug. He also took his own medicine — and says he watched the molecule's exact 3D structure rotate in front of him for 36 hours straight.Expect to learn why ibogaine breaks every rule of classical pharmacology, what "matrix pharmacology" means and why it's heresy to a one-drug-one-target industry, how editing a single atom deletes ibogaine's fatal heart risk, why a common antidepressant turned out to be a secret opioid for thirty years, what it's like to watch a molecule's structure appear during a 36-hour flood dose, why ibogaine seems to erase interest in alcohol overnight, whether the "DMT block" phenomenon researchers describe is real, and much more…

Timestamps0:00:00

Trailer0:02:39

Meet the Chemist Who Fell for a Molecule's Shape

0:04:13 The Dogma That the Adult Brain Can't Heal0:09:00 Why Synapses Might Explain Every Brain Disorder0:10:28 Reverse-Engineering Nature's Own Drugs

0:16:44 The Paper That Changed Everything About Addiction

0:20:01 Why Ibogaine Breaks Every Rule of Pharmacology

0:33:08 The Weakest Drug That Works the Strongest

0:38:21 The Traffic Jam That Explains Matrix Pharmacology

0:44:18 A Human Genome Project — For One Molecule

0:47:48 Deciding to Take Ibogaine Himself

0:50:02 Inside a 36-Hour Flood Dose

0:54:38 The Chapter Called "Treatment"

0:56:26 Ibogaine Shows Him the Future of Design

1:00:01 Seeing Ibogaine's 3D Molecular Structure

1:03:14 High-Fiving a Molecule1:06:47 "This Is a Computational Technology"

1:16:36 The Simulation So Real It Panicked Him

1:24:26 Did He Earn This Experience?

1:30:56 Six Months Later — What Actually Changed

1:36:01 Did This Change His View of Consciousness?......

Email for sponsorship enquiries: [email protected]

GS Episodes Mentioned

Andrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDA

David Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5oGuest

LinksColumbia Chemistry faculty page: https://www.chem.columbia.edu/content/dalibor-sames

Sames Lab: https://www.samesgroup.org/professor-dalibor-sames

Gilgamesh Pharmaceuticals: https://www.gilgameshpharmaceutical.com/

Oxa-Iboga paper (Nature Communications, 2024): https://doi.org/10.1038/s41467-024-51856-y

Beond Ibogaine Clinic (where he took ibogaine): https://beondibogaine.com

Download the most scientifically rigorous nutrition app MacroFactor! Use code GIANTS for a 2 week FREE trial: https://onelink.to/giants

Want a full breakdown of your own conscious inner experience?

Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

Dráulio Barros de Araújo is a physicist who spent twenty years pointing MRI scanners at the ayahuasca experience, and ran the world's first controlled trial proving a single dose of a psychedelic could lift treatment-resistant depression in a week. He thinks DMT entity encounters are not hallucinations, and he wants to know if they could be real.Expect to learn why calling ayahuasca visions "hallucinations" is scientifically wrong, why you can't overdose or build tolerance to ayahuasca the way you can with alcohol or cocaine, why vomiting is considered part of the medicine rather than a side effect, how a physicist measured the entropy of a mystical experience and watched it rise, why your eyes physically won't stay open during a vision, the hippocampal memory glitch that may explain why DMT entities feel real, and why psychedelic science may be measuring altered states with the wrong tools entirely.

Timestamps

0:00:00 Trailer

0:02:50 Who Is the Physicist Studying Ayahuasca Visions

0:05:05 The 1930s Origin of Brazil's Ayahuasca Churches

0:10:13 Why You Can't Buy Ayahuasca Like a Coca-Cola

0:11:22 What a Typical Ayahuasca Trip Actually Feels Like

0:16:53 Why LSD Visions Happen With Eyes Open, Ayahuasca Doesn't

0:17:22 Your Brain on Ayahuasca Looks Like a Dream, Not a Hallucination

0:21:08 Why Ayahuasca Visions Never Feel Like "Just a Dream"

0:22:23 There's No Such Thing as an Ayahuasca Overdose

0:24:18 Why Vomiting and Diarrhea Are Part of the Medicine

0:28:34 The Hippocampus Theory of Why DMT Entities Feel Real

0:33:22 Would Irish People See Snakes on Ayahuasca Too?

0:35:40 We're Measuring Trips With the Wrong Scientific Tools

0:40:44 Speech Analysis: A New Way to Study the Trip

0:44:31 The Flawed Questionnaire Behind Every Psychedelic Study

0:50:23 Why Dráulio Refuses to Ask a Single Direct Question

0:55:19 The Entropic Brain Hypothesis, Explained by a Physicist

1:02:01 Why Psychedelics Dissolve Your Career Ambitions

1:04:02 The Most Important Psychedelic Question Science Avoids: Death

1:06:09 What the West Should Learn From Indigenous Ayahuasca Traditions...

Email for sponsorship enquiries: [email protected]

GS Episodes Mentioned

David Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5o

Robin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://www.youtube.com/watch?v=t-GkE4YtLRk

David Nutt — Neuroscientist Ranks Every Drug By How Hard They Are to Quit! Tier List Part 2: https://www.youtube.com/watch?v=CEgbv6IHYaY

Guest Links

UFRN Brain Institute — Faculty Profile: https://neuro.ufrn.br/institute/members/investigators/draulio

Google Scholar: https://scholar.google.com/citations?user=NoO4Rt0AAAAJ

Centro Avançado de Medicina Psicodélica (CAMP): https://www.camp-sci.com/ptLinkedIn: https://www.linkedin.com/in/draulio-araujo-06ab47125

Get Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10

Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

Dennis McKenna is an ethnopharmacologist who spent fifty years decoding the chemistry of psychedelic plants, producing the first hard pharmacological proof of why ayahuasca actually works. He's also the younger brother of Terence McKenna, and in 1971 the two of them ran an experiment on their own minds in the Colombian Amazon that ended in a two-week psychotic break neither has ever fully explained.Expect to learn why the McKenna brothers thought DMT was a portal to another dimension rather than a drug trip, what happened during Dennis's two-week dissociation from reality in the Amazon, how ayahuasca's DMT and MAO-inhibitor plants actually work together in the body, why Dennis still calls the entire 1971 expedition "an act of science fiction, not science," how his PhD research became the first pharmacological proof of why ayahuasca works, why he thinks his own brother unintentionally seeded the "machine elf" into everyone else's DMT trips, why a career pharmacologist has never personally seen one himself, and why DMT entity encounters may be linked to real mental health outcomes, and much more…

Timestamps

0:00:00 Trailer

0:03:07 How Dennis Got Into Psychedelics

0:06:07 Terence The Philosopher vs Dennis The Scientist

0:11:11 The 1971 Expedition To The Colombian Amazon

0:16:05 Why DMT Was "The Holy Grail"

0:17:50 The Ayahuasca Chemistry Nobody Understood Yet

0:18:45 Hunting For The Legendary Oo-Koo-Hé

0:22:00 Stumbling Into A Mushroom Paradise

0:27:05 When The Mushrooms Started "Talking"

0:28:38 The DNA Resonance Experiment

0:36:01 The Two-Week Psychotic Break

0:40:46 Psychotic Break, Shamanic Initiation, Or Alien Encounter?

0:47:08 From Psychotic Break Back To The Lab

0:53:16 Proving How Ayahuasca Actually Works

0:58:47 The Book That Seeded Mushrooms Into Society

1:05:39 Sasha Shulgin And The Chemistry Of Psychedelics

1:11:02 "I've Never Seen A Machine Elf Myself"

1:17:56 Pushing The DMT Experience To Five Hours

1:20:02 What Makes DMT Different From Psilocybin

1:26:18 DMT Entities And Mental Health Outcomes......

Email for sponsorship enquiries: [email protected]

Episodes MentionedAndrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDA

David Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5oGuest Links

Heffter Research Institute Bio: https://www.heffter.org/dennis-j-mckenna-phd/

McKenna Academy of Natural Philosophy: https://mckenna.academy/mka-team/dennis-mckenna/

X: https://x.com/DennisMcKenna4Book — The Brotherhood of the Screaming Abyss: http://brotherhoodofthescreamingabyss.com/

ResearchGate: https://www.researchgate.net/profile/Dennis-Mckenna

Get Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulder

Get Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10

Denis Noble is the physiologist who built the first computer model of the heart in 1960 — and has spent the sixty years since using it to dismantle the gene-centric view of life that dominates modern biology. He took Richard Dawkins's Selfish Gene and rewrote its most famous passage word for word in reverse — and every single experiment still fits.Expect to learn why the central dogma of molecular biology is provably wrong, how your immune system rewrites its own DNA to fight off new viruses, why the peppered moth story in every biology textbook turns out to be false, what happened when Denis told Richard Dawkins "Lamarck is back" to his face, why a cell corrects roughly 800,000 DNA replication errors before it's allowed to divide, how epigenetic inheritance can persist indefinitely if the environment stays changed, whether plants might have a form of experience, and where exactly agency ends and pure chemistry begins.

Timestamps

0:00:00 Trailer

0:02:27 Meet The Man Who Modeled The Heart By Hand

0:04:43 Why The Central Dogma Of Biology Is Wrong

0:06:39 The 1866 Split Between Darwin And Wallace

0:09:02 The Infinite Monkey Theorem, Tested For Real

0:17:30 The Peppered Moth Myth Textbooks Still Teach

0:20:19 The Nobel Laureate Textbooks Forgot To Cite

0:22:53 Telling Richard Dawkins "Lamarck Is Back"

0:27:43 Was Lamarck's Giraffe Neck Story Actually Right?

0:29:40 How Your Body Talks To Your DNA

0:38:17 A New Species Evolved In Two Generations

0:44:18 So What's Actually Controversial Here?

0:48:09 Cellular Agency: When Cells Act Like Organisms

0:53:04 Steelmanning The Case Against Cellular Agency

0:55:05 The 17th-Century Prediction That Proved Purpose Works

1:04:20 Your Cells Correct 800,000 DNA Errors Per Division

1:13:14 Life Lives On The Edge Of Order And Chaos

1:15:27 Do Plants Have Experience?

1:27:31 How Does Consciousness Fit Into Systems Biology?......

Email for sponsorship enquiries: [email protected]

GS Episodes Mentioned

Michael Levin — Meet the Scientist Creating New Forms of Synthetic Life! Dr Michael Levin: https://www.youtube.com/watch?v=LTBZRVKUwyM

Philip Ball — Philip Ball: "Biology Is Infinitely Weirder Than We Thought": https://www.youtube.com/watch?v=9SseGx0R0fY

Guest Links

Oxford Faculty Page: https://www.dpag.ox.ac.uk/team/denis-noblePersonal Website: https://www.denisnoble.com

Google Scholar: https://scholar.google.com/citations?user=J6kLmsIAAAAJ&hl=en

Understanding Living Systems (Book): https://www.amazon.com/Understanding-Living-Systems-Life/dp/1009277367

The Third Way of Evolution: https://www.thethirdwayofevolution.com/people/view/denis-noble