Longevity medicine is full of exciting ideas: rapamycin, peptides, supplements, and emerging therapies. But before worrying about any of them, have you actually assessed the diseases most likely to kill or disable you?
In this episode, Jon Brudvig, PhD and Dr. Grant Fraser walk through Dr. Fraser's approach to longevity-focused primary care: identifying disease early, measuring risk more directly, and addressing the fundamentals before moving on to more speculative interventions.
From cardiovascular imaging and metabolic health to cancer screening, bone density, frailty, infections, hearing loss, and cognitive decline, this conversation lays out a practical framework for understanding where you stand today—and what may be worth doing about it.
In this episode:
• Why “normal” labs and conventional risk scores don’t necessarily mean you’re disease-free
• Why Dr. Fraser puts cardiovascular and metabolic health at the top of the longevity hierarchy
• The role of coronary CT angiography, brain and vascular MRI, and other advanced imaging
• ApoB, lipoprotein(a), insulin sensitivity, blood pressure, omega-3 index, hsCRP, and other biomarkers
• Whole-body MRI for cancer screening—and the real tradeoff between early detection and false positives
• Why Grant uses low-dose lung CT even in some nonsmokers
• DEXA scans for bone density, visceral fat, body composition, and sarcopenia
• How infections and vaccination become increasingly important with age
• Hearing loss, dental health, vascular disease, and other overlooked contributors to cognitive decline
• Why diet, exercise, sleep, stress, and conventional prevention should come before the “clever” longevity interventions
Follow the hosts:
Jon Brudvig, PhD — Translation on Substack
https://jonbrudvig.substack.com
Grant Fraser, MD — Longevity & Precision Primary Care
https://www.grantfrasermd.com
