Welcome back to Rad Onc Smart Review, Genitourinary Oncology edition. This is Episode 9: a discussion on prostate cancer across the metastatic continuum, including metastatic hormone-sensitive disease, nonmetastatic castration-resistant disease, metastatic castration-resistant disease, metastasis-directed therapy, and precision systemic therapy. We'll cover how to move from localized to advanced disease by defining the disease state, the burden, and how biomarkers impact management.