Dr Toni Choueiri, Chief of GU Oncology at Dana-barber Cancer Institute (Boston, USA) returns to GU Cast with members of his team at Dana Farber Cancer Institute to discuss our favourite lists of top GU Oncology papers for 2024. Toni has posted these now legendary lists at the end of each year on Twitter/X since the start of Covid, and they have become essential reading for anyone wanting a superb overview of top trials. Each tweet contains a top line summary of each trial and key images such as K-M curves, plus links to the original papers. A huge amount of work and a great resource.

Today we are joined by Toni along with Dr Marc Eid and Dr Emre Yekeduz who helped compile this year's lists. We hear about the process behind it all, and we run through their Top 10 Bladder and Renal Cancer papers, and their Top 5 Prostate Cancer papers. The team also post their Top 10 Translational papers and Their Top 10 non-GU Oncology papers.

Well done again to Toni, Marc, Emre and team! Links to the tweets below.

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Links:
Top 10 Bladder and Renal Cancer Papers

Top 5 Prostate Cancer Papers 

Part 2 of our GU Cast Conference Highlights from Shanghai including discussions with Dr Stephen Freedland (Los Angeles), Dr Liang Liang (Shaanxi), Dr Andrea Necchi (Milano), Dr Xiaojie Bian (Shanghai), and Dr Hongkai Wang (Shanghai).  Declan Murphy travelled to Shanghai for the 14th GU Oncology Academic Meeting hosted by Fudan University Shanghai Cancer Centre, and to meet up with our GU Cast China Editor, Dr Yao Zhu. This is an excellent meeting in one of our very favourite cities. In Part 1 we spoke to Conference Chair, Dr Dingwei Ye, Dr Karim Fizazi, Dr Peng Wu, and Dr Axel Merseburger, to overview the latest stories in GU Oncology. 
Special thanks to our Conference Highlights Partner, Bayer China, who set up an amazing GU Cast studio for us in Shanghai. Thanks to Hexun and all the local Bayer team in China.  

Also available as an audio podcast - just search GU Cast wherever you get your podcasts

Declan Murphy travels to Shanghai for the 14th GU Oncology Academic Meeting hosted by Fudan University Shanghai Cancer Centre, and to meet up with our GU Cast China Editor, Dr Yao Zhu. This is an excellent meeting in one of our very favourite cities, and this year Declan joins International Faculty including Dr Stephen Freedland (Los Angeles), Dr Karim Fizazi (Paris), Dr Axel Merseburger (Lubeck). and Dr Andrea Necchi (Milano) to overview the latest stories in GU Oncology. Top Chinese experts from across the country also join and the meeting includes some landmark consensus statements from multidisciplinary panels.
Today we post Part 1 of our GU Cast Conference Highlights from Shanghai including discussions with Conference Chair, Dr Dingwei Ye, Dr Karim Fizazi, Dr Peng Wu, and Dr Axel Merseburger.
Special thanks to our Conference Highlights Partner, Bayer China, who set up an amazing GU Cast studio for us in Shanghai. Thanks to Hexun and all the local Bayer team in China.

Even better on our YouTube channel 

Our final episode of the year! And we end with a very seasonal celebration of single-port surgery and the Boxing Day Test with Australia playing India in one of the world's most famous cricket matches. We coaxed Dr Mihir Desai (University of Southern California, Los Angeles) and A/Prof Daniel Moon (Peter Mac, Melbourne) out of the Melbourne Cricket Ground and into our nearby studio at the close of play on Day 2 to talk all things single-port surgery (and cricket). Cricket-mad Mihir flew in from LA to tick off his bucket list ambition of attending a Boxing Day Test. We reminisce about the early days of single-port laparoscopy and talk about what robotic surgery does (and does not) bring to single-port surgery.
Plus we remember the day that Indy Gill met Shane Warne at the MCG ten years ago while attending a meeting here! Two legends of their games.
And to end season 5 of GU Cast, your hosts Declan Murphy and Renu Eapen thank our amazing Partners for supporting our ever expanding pool of content from GU Cast.

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Links:
BJUi Blog about when Indy met Warnie 

Have you ever found the choice of agents in metastatic kidney cancer just a bit perplexing??! Well then this is the podcast for you! To celebrate a fantastic review paper recently published in European Urology, we chat with first author Dr Regina Barragan-Carillo (City of Hope, California), and second senior author Dr Tian Zhang (UT South-Western, Texas). The title of the paper is "First and Second-line Treatments in Metastatic Renal Cell Carcinoma", and it's about the best paper we have read on this topic, with a proper who's who in renal cancer contributing. Plus completely up to date with a literature review up to October 2024. 

Co-hosts Declan Murphy and Renu Eapen really enjoyed this one! 

This is a Themed Podcast supported by our Bronze Partner, Ipsen Pharmaceuticals.

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Links:
European Urology paper (paywall) 

Legendary British cyclist Sir Chris Hoy (48) recently shocked the world by announcing that he has progressive metastatic prostate cancer. His specialists have given him a 2-4 year life expectancy. The dreadful news that no prostate cancer patient wants to hear.
Today, hosts Prof Declan Murphy and Dr Renu Eapen welcome their good mates A/Prof Ben Challacombe (Guy's Hospital, London), and A/Prof Daniel Moon (Peter MacCallum Cancer Centre, Melbourne) to the GU Cast studio, and patient advocate Andrei Norris who joins on Zoom to discuss the huge publicity this has generated, and the importance of family history in assessing men's risk of prostate cancer.

This is a Themed Podcast supported by our Silver Partners, Bayer Pharmaceuticals.

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Part 2 Highlights from a GU Cast Live Event! Dr Kim Chi (Medical Oncologist, Vancouver) and Dr Carmen Mir (Urologist, Valencia) joined the PROSPECT meeting in Melbourne to discuss high-risk prostate cancer and mHSPC, along with many experts from around Australia. On the eve of the meeting over dinner, Declan Murphy led a GU Cast-themed panel discussion on five hot topics in prostate cancer, featuring snippets from GU Cast over the past few months.Part 2 today features controversies in PLND, the somewhat notorious ARPI switch control arm beloved of mCRPC trials, and teh importnt topic of de-escalation in advanced prostate cancer. Part 1 recently in your feeds included PSMA conundrums and triplet vs doublet therapy.

Even better on our YouTube channel

This is a Themed Podcast supported by our Gold Partners, Johnson & Johnson, who also support the PROSPECT meeting. 

Special thanks to David Chen for help with videography

What are we to make of this large RCT of extended vs standard pelvic lymph node dissection (PLND) for prostate cancer?? Despite it not meeting its primary endpoint of improving biochemical recurrence, the authors now report in European Urology that it does reduce the incidence of distant metastases 10 years later! Go figure!
We chat with Dr Karim Touijer (MSKCC) and try to figure it out. We ask about data dredging, p-hacking and statistical shenanigans, and how adding two minutes and two extra lymph nodes to a PLND could possibly lead to reduced metastases.
Plus guest comments from Dr John Yaxley (Brisbane). What do you think??!! Will this change practice?? Will this change guidelines? Tune in and share your thoughts!

Even better on our YouTube channel
Links:
Paper in European Urology
Previous GU Cast with Karim discussing earlier paper (Feb 2022) 

Highlights from a GU Cast Live Event! Dr Kim Chi (Medical Oncologist, Vancouver) and Dr Carmen Mir (Urologist, Valencia) joined the PROSPECT meeting in Melbourne to discuss high-risk prostate cancer and mHSPC, along with many experts from around Australia. On the eve of the meeting over dinner, Declan Murphy led a GU Cast-themed panel discussion on five hot topics in prostate cancer, featuring snippets from GU Cast over the past few months. Part 1 today features PSMA conundrums and triplet vs doublet therapy.

Even better on our YouTube channel

This is a Themed Podcast supported by our Gold Partners, Johnson & Johnson, who also support the PROSPECT meeting. 

Special thanks to David Chen for help with videography

A GU Cast Live Event!! Everything you need to know about treatment intensification in mHSPC!! Doublet vs Triplet. Who should have radiotherapy? PSMA PET/CT conundrums, e-escalation, case discussions and more. Featuring GU Cast Hosts Declan Murphy and Renu Eapen, Medical Oncologist Ben Tran, Nuclear Medicine Physician Louise Emmett, and Radiation Oncologist Amy Hayden. Plus lots of interaction from our live audience around Australia.
Watch the full webinar including presentations on our YouTube channel

This GU Cast Live Event was an interactive educational webinar supported by our Gold Partners, Mundipharma.

Learning objectives:
1. Provide an overview of the landscape of mHSPC today, with a particular focus on intensification of therapy
2. Provide an overview of the role of novel and conventional imaging in diagnosis of mHSPC, both synchronous
 and metachronous
3. To better understand options for intensification of systemic therapy in mHSPC
4. To better understand the role of radiotherapy in mHSPC