Dr Amar Kishan (Radiation Oncologist, UCLA, USA), made lots of headlines recently when he presented data from the phase II randomised LUNAR trial of SABR +/- LuPSMA in patients with oligometastatic prostate cancer. So we were very happy when he turned up in Melbourne recently and popped into the GU Cast studio for a chat. We discuss metastasis-directed therapy and bring up our favourite Pokemet analogies, and ask should we not just be offering these patients and ADT/ARPI doublet?! 

Regular hosts Declan Murphy and Renu Eapen, also joined by Prof Wee Ong, Radiation Oncologist at Alfred Health in Melbourne. 

This is a Themed Podcast supported by our Gold Partners, Johnson & Johnson. 

Even better on our YouTube channel 

Fun today as we go to the OR to test drive some high-fidelity radical prostatectomy models and chat with the team behind UroTrainer - world leaders in urologic simulation. Urologists Gonzalo Vitagliano and Maxi Ringa join us from Buenos Aries to tell us all about UroTrainer and why they have worked hard to create these beautiful models for trainees to improve their skills in minimally-invasive prostate and kidney surgery. 

They also tell us about their range of hands-on courses around the world and their innovative remote laparoscopic training courses so trainees can do training from home while being proctored remotely. 

Declan Murphy also joins senior trainees Christa Babst and Eoin Dinneen in the OR as they test the construct validity of three prostatectomy models using a da Vinci surgical robot. These are beautiful simulation models, best in the business in our view! Well done to the UroTrainer team and keep up the good work.

Thsi one best appreciated on our YouTube channel

Links:
Urotrainer website 

One of our favourite meetings of the year! The EAU Robotic Urology Section (ERUS) Annual Meeting took place in London recently and was an unashamed exposition of robotic surgery in urology. More than 30 amazing live surgeries, and some fantastic plenary sessions focussing on technical aspects. Multiple different robots, and spectacular telesurgery with surgeons sitting in London, performing robotic surgery up to 8000km away! 

Join Host Declan Murphy to get a flavour of this year's meeting, and to hear from many of the surgeons involved.

With thanks to our Silver Partners, Device Technologies. 

This one best appreciated on our YouTube channel.

Episode 3 of our monthly GU Cast Journal Club and today we focus on one classic paper in Urology, and one from recent times - the ERSPC randomised trial of screening in prostate cancer, and the NIAGARA trial evaluating peri-operative immunotherapy in muscle-invasive bladder cancer. 

We are delighted to welcome back our GU Cast Journal Club Editors, Dr Carlos Delgado (Melbourne, AUS), and Dr Elena Berg (Munich, GER), along with main GU Cast Hosts, Renu Eapen and Declan Murphy. Watch out for Declan getting all misty-eyed recalling when the ERSPC was published back in 2009 (the rest of the team are too young to remember this)!

Links to papers below:
1. Screening and Prostate-Cancer Mortality in a Randomized European Study NEJM 2009

2. Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer NEJM 2024

GU Cast Journal Club is supported by our Partner, MSD, through an unrestricted educational grant.

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About GU Cast Journal Club:
Each month, two papers are discussed, each of which are of importance to the GU Oncology community. These may be recent papers, or occasionally we will chose a classic landmark paper in GU Oncology
. The objective is to draw attention to important papers in GU Oncology, and critique these in a robust manner
. The key target audience is trainees working in Urology, Medical Oncology, Radiation Oncology, Nuclear Medicine, and diagnostic specialties such as Radiology and Pathology. But any of our regular audience are likely to enjoy this Journal Club series.

Another of our deep-in-the-weeds theranostic webinars in conjunction with our friends at ProsTiC, and the Prostate Cancer Foundation. This one focussed on Terbium-161, a very exciting new option in metastatic prostate cancer. 
Your hosts are Dr Renu Eapen and Professor Michael Hofman, with Dr Howard Soule and Dr Andrea Miyahira from the Prostate Cancer Foundation. Special guests include Dr James Buteau (Peter Mac, Melbourne, Australia), Dr Alin Chirindel (Universitätsspital Basel), Prof Dr Samer Ezziddin (Saarland University Hospital, Germany) and Prof. Cristina Müller (Paul Scherrer Institute, Switzerland)

Is Terbium-161 superior to Lutetium-177? You'll hear about the latest clinical trials, experience and translational research from world leaders using Terbium-161.

Enjoy multi-disciplinary discussion covering nuclear medicine, radiopharmaceutical sciences, medical oncology, urology, radiation oncology, medical physics, translational sciences & industry.

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Hot off the press in the Presidential Plenary at #ESMO25, we chat with Dr Scott Tagawa (Weill-Cornell, USA) about the positive data he just presented from the PSMAddition trial. This is an eagerly awaited phase III randmosied trial of patients with mHSPC, to see if the addition of six cycles of Lu-PSMA-617 to a control arm of ADT and an ARPI, could improve rPFS and other endpoints. We are also joined in the studio by Prof Michael Hofman (Peter MacCallum Cancer Centre, AUS), co-PI of the UpFront PSMA trial which also explored a similar concept, plus some comments from our other colleague, prof Arun Azad, who was the Discussant in the Presidential at ESMO25. 
Declan Murphy hosting GU Cast solo today while Renu Eapen was in the OR doing surgery. 

Even better on our YouTube channel

This is a Themed Podcast supported by our Silver Partners, Novartis.

Never heard of Common Sense Oncology?? Well if you enjoy this podcast then we think you will might find the Common Sense Oncology (CSO) movement to be very interesting indeed!

Declan Murphy caught up recently with Dr Bishal Gyawali, Medical Oncologist at Queen's University, Kingston, Ontario, to talk about CSO which he co-founded in 2023. They are on a mission to ensure that cancer care and innovation, should focus on results that are meaningful to patients (eg survival, quality of life, equity), rather than just regulatory approval, commercial success, or statistical endpoints. "Outcomes that matter", is their battle cry.

They are also very focussed on communication, and are quick to call out when stakeholders make ridiculous claims for their product or innovation. And Bishal happens to be one of the very best communicators out there. Great to have him on GU Cast and we at GU Cast are 100% supportive of their mission.

You can visit their website and join the movement for all the latest updates

The Urological Association of Asia (UAA) Annual Meeting is always a great cultural event with a focus on the local community. And Taipei certainly put on a great show! Lots of fantastic entertainment and great local cuisine, plus of course a great scientific program, with a focus on AI, single port robotic surgery, novel robot systems, and lots more across the breadth of Urology.

Join hosts Renu Eapen and Declan Murphy, who bring you a great flavour of UAA in Taipei, speaking to many local and international guests. 

Even better on our YouTube channel

GU Cast Conference Highlights are supported by our Conference Highlights Partner, Bayer China. 

They started off by introducing themselves as The Three Horsemen of the Apocalypse - what could possibly go wrong!! Declan couldn't resist the opportunity to invite three very eminent radiation oncologists into the studio when they all happened to be in Melbourne, even if he was particularly outnumbered while Renu was away! Vedang Murthy (Tata Memorial, India), Andrew Loblaw (Sunnybrook Hospital, Canada), and Sarat Chander (Peter Mac, Melbourne) are all highly specialised in prostate radiation, so Declan invited them into the GU Cast studio to pick their brains on three big areas in prostate radiation:
1. Hypofractionation in 2025 - Who and How?
2. Who needs ADT and for how long when having prostate radiation?
3. Metastasis-directed therapy for oligometastatic disease - is there any point??

Tune in to find out how Urologist Declan Murphy fared up against these three Radiation Oncologists!!! Even better on our YouTube channel

This podcast is supported by our Bronze Partner, Icon Cancer Centre.

We never need an excuse to visit Sydney, and for sure when one of our favourite meetings of the year is in the Harbourside City then count us in! The Annual Meeting of ANZUP is something we try and get to every year and have really enjoyed bringing you highlights. This year we catch up with some international faculty including Roger Li (Moffitt Cancer Centre, USA), ANZUP Prostate Cancer Committee bosses Lisa Horvath (Chris O'Brien Lifehouse) and Jarad Martin (Genesis Care), Dickon Hayne (Fiona Stanley Hospital) regarding his NMICB RCT, and Bernie Reilly (Prostate CAncer Foundation of Australia) about some fantastic resources for prostate cancer patients. 

Big congrats to all at ANZUP for another excellent meeting and for all they do for GU oncology in Australia and New Zealand. 

PS - apologies for some sub-standard audio on this one. 

GU Cast Conference Highlights are supported by our Conference Highlights Partner, Bayer.