This is Episode 1: Prostate – Anatomy, Pathology, Risk Groups, and Natural History. This foundational episode covers everything in the prostate series – dose escalation, hypofractionation, brachytherapy, ADT integration, salvage, and oligometastatic management – as we delve deep into three key areas. First, prostate anatomy, including zonal architecture, lymphatic drainage, and adjacent structures that influence local cancer extension and target volume design. Second, risk stratification using Grade Group, PSA, T stage, and biopsy tumor volume – the four key variables for prostate cancer patient classification. Third, natural history, examining landmark data to identify aggressive cancers, understand non-lethal cases, and apply competing-risk thinking to determine appropriate treatment strategies.