Episodes 3 through 7 covered definitive treatment. This episode covers what to do when definitive treatment fails. After prostatectomy, earlier salvage RT at lower PSA is associated with better outcomes. After prior RT or focal therapy, salvage can still be curative in selected patients, but it requires careful restaging and biopsy confirmation before local retreatment. Today we will cover four things: the shift from routine adjuvant RT to early salvage RT after prostatectomy, the selective role of ADT and pelvic nodal coverage in the salvage setting, the workup for recurrence after RT or focal therapy, and the major salvage options for radiorecurrent disease.