Healio Minute

In this edition, multicancer detection tests show promise; lifestyle counseling appointments benefit cancer survivors; use of low-value drugs for patients with cancer, and more.

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Multicancer detection tests show promise, but questions linger about their accessibility

Shared medical appointments for lifestyle counseling benefit cancer survivors

Industry payments to physicians spur use of low-value drugs for patients with cancer

Study shows link between ultraprocessed foods and mortality risk

Radiation oncologist appointed to leadership role at NYU Langone's Perlmutter Cancer Center

References:

Mitchell AP, et al. BMJ. 2023;doi:10.1136/bmj-2023-075512. Press Release Westgate C, Fischer J. What primary care physicians need to know about multicancer early detection tests. Presented at: OMED; Oct. 5-8, 2023. Winters LN. The development of an advanced practice nurse and registered dietician-led lifestyle medicine shared medical appointment program for cancer survivors. Presented at: Lifestyle Medicine 2023; Denver; Oct. 29-Nov. 1, 2023. Zhao Y, et al. Am J Prev Med. 2023;doi:10.1016/j.amepre.2023.09.005.

In this edition, FDA approves Bimzelx for plaque psoriasis; roflumilast foam improves quality of life in patients with seborrheic dermatitis and more. Read the full coverage here:

FDA approves Bimzelx for treatment of moderate to severe plaque psoriasis

Roflumilast foam improves quality of life in patients with seborrheic dermatitis

Opzelura effective, well tolerated in children aged at least 2 years with atopic dermatitis

Treatment for onychomycosis prescribed at only 20% of visits, impacting quality of life

Study: Important to weigh berdazimer gel benefits vs. risks in molluscum contagiosum

References:

Calvi IP, et al. Pediatr Dermatol. 2023;doi:10.1111/pde.15419.

Chu D. et al. Poster. Effect of roflumilast foam 0.3% on quality of life in patients with seborrheic dermatitis: patient-reported outcomes from the STRATUM phase III trial. Presented at: AMCP Nexus; Orlando.

Peck GM, et al. J Drugs Dermatol. 2023;doi:10.36849/JDD.6770.

Press Release

Press Release

In this edition, FDA issues complete response letter for relabotulinumtoxinA; mucocutaneous manifestations may signal COVID-induced inflammatory disease in children and more. Read the full coverage here:

FDA issues complete response letter for relabotulinumtoxinA for frown lines, crow's feet

Mucocutaneous manifestations may signal COVID-induced inflammatory disease in children

FDA approves Zoryve for pediatric psoriasis

Colloidal oatmeal, prescription cream comparable in Black children with atopic dermatitis

FDA issues complete response letter for lebrikizumab for eczema treatment

References:

Imam B. Mucocutaneous clinical manifestation of multi-system inflammatory syndrome in children (MIS-C). Presented at: Skin of Color Update; Oct. 6-8, 2023; New York.

Lisante TA, et al. J Dermatolog Treat. 2023;doi:10.1080/09546634.2023.2241587.

Press Release

Press Release

Press Release

In this edition, precision navigators reduce racial disparities in genomic testing; cancer diagnoses fell sharply during early days of pandemic; Prostate Cancer Awareness Month updates, and more.

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Precision navigators reduce racial disparities in genomic testing for prostate cancer

Cancer diagnoses fell sharply during early days of pandemic, NCI report shows

Prostate Cancer Awareness Month: Financial hardship common, exercise beneficial

Researchers identify 11 genes linked to aggressive prostate cancer

Black men less likely to receive targeted therapy for metastatic prostate cancer

References:

Allen AJ, et al. Abstract 122. Presented at: ASTRO Annual Meeting; Oct. 1-4, 2023; San Diego. Darst BF, et al. JAMA Oncol. 2023;doi:10.1001/jamaoncol.2023.3482. Healio Coverage Hwang C, et al. JAMA Netw Open. 2023;doi:10.1001/jamanetworkopen.2023.34208. Negoita S, et al. Cancer. 2023;doi:10.1002/cncr.35026.

In this edition, retinoids and OTC products for photoaged skin; fractional lasers show promise in skin cancer prevention; a botanical drug for severe thermal burns and more. Read the full coverage here: Prescription retinoids, OTC products positively impact photoaged skin

Fractional lasers show promise in skin cancer prevention

Botanical drug may outperform standard of care for treatment of severe thermal burns

5-fluorouracil cream noninferior to surgery for Bowen's disease

Perifollicular linear projections aid in early diagnosis of facial lentigo maligna

References:

Ahmady S, et al. J Am Acad Dermatol. 2023;doi:10.1016/j.jaad.2023.08.076.

McCormick ET, et al. J Drugs Dermatol. 2023;doi:10.36849/JDD.2023.NVRN0923.

Navarrete-Dechent C, et al. J Am Acad Dermatol. 2023;doi:10.1016/j.jaad.2023.07.1036.

Press Release

Sadick N, et al. J Drugs Dermatol. 2023;doi:10.36849/JDD.7753.

In this edition, CDC issues a health advisory concerning flesh-eating bacterium, staging for melanoma does not represent accurate recurrence and mortality and more. Read the full coverage here:

CDC issues health advisory about recent reports of fatal Vibrio vulnificus

Study finds melanoma treatment costs have increased, but so has survival

Melanoma staging system inaccurately reflects recurrence, mortality risk

Study: Nemolizumab shows promise as prurigo nodularis treatment

Adverse events after ICI treatment linked to improved outcomes in patients with melanoma

References:

Bateni SB, et al. JAMA Dermatol. 2023;doi:10.1001/jamadermatol.2023.3179.

Deng J, et al. JAMA Dermatol. 2023;doi:10.1001/jamadermatol.2023.2609.

Du Y, et al. JAMA Dermatol. 2023;doi:10.1001/jamadermatol.2023.3003.

Helvind NM, et al. JAMA Dermatol. 2023;doi:10.1001/jamadermatol.2023.3256.

Press Release

In this edition, nearly $1 million in grants to aid diversity, equity, inclusion research; topical halcinonide may benefit patients with psoriasis; Asian patients may experience earlier mycosis fungoides diagnosis and more. Read the full coverage here:

Nearly $1 million in grants to aid dermatology research in diversity, equity, inclusion

Topical halcinonide may benefit patients with psoriasis with inadequate biologics response

Asian patients may experience earlier mycosis fungoides diagnosis, better outcomes

COVID-19 pandemic led to delayed melanoma diagnoses, more advanced tumors

Dupilumab use correlates with S. aureus reductions, atopic dermatitis improvements

References:

Bagel J, et al. J Drugs Dermatol. 2023;doi:10.36849/JDD.6830. Chen Z, et al. JAMA Dermatol. 2023;doi:10.1001/jamadermatol.2023.2634. Press Release Simpson EL, et al. J Allergy Clin Immunol. 2023;doi:10.1016/j.jaci.2023.05.026. Xiong D, et al. J Am Acad Dermatol. 2023;doi:10.1016/j.jaad.2023.08.040.

In this edition, 'equitable access' to care may reduce racial disparities in survival; exercise may improve sexual function among men with prostate cancer; image-guided adaptive prostate radiation therapy for short-term toxicities, and more.

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'Equitable access' to care may reduce racial disparities in prostate cancer survival

Exercise may improve sexual function among men with prostate cancer

Image-guided adaptive prostate radiation therapy reduces risk for short-term toxicities

Recent developments in advanced prostate cancer space pave way for future breakthroughs

Radiation plus intensive systemic therapy improves outcomes in prostate cancer subset

References:

Bossi A, et al. Abstract LBA5000. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago.

Galvao DA, et al. Abstract 71. Presented at: ASCO Breakthrough; Aug. 3-5, 2023; Yokohama.

Leeman JE, et al. Cancer.2023;doi:10.1002/cncr.34836.

Sayegh N, et al. JAMA Netw Open. 2023;doi:10.1001/jamanetworkopen.2023.26546.

Sharifi N, et al. J Clin Oncol. 2023;doi:10.1200/JCO.2022.40.16_suppl.5022.

In this edition, M-PDT efficacy similar to isotretinoin in acne vulgaris; Spitz neoplasm diagnosis in adults; immunotherapy treatment shows promise in basal cell carcinoma and more. Read the full coverage here:

M-PDT efficacy similar to isotretinoin in acne vulgaris

Clinicians should not 'shy away' from a Spitz neoplasm diagnosis in adults

Novel nonsurgical immunotherapy treatment shows promise in basal cell carcinoma

Remibrutinib potential first-in-class oral treatment for chronic spontaneous urticaria

Clascoterone cream exhibits significant long-term improvement among children with acne

References:

Eichenfield LF, et al. J Drugs Dermatol. 2023;doi:10.36849/JDD.7592. Hagstrom M, et al. J Am Acad Dermatol. 2023;doi:10.1016/j.jaad.2023.08.005. Press Release Press Release Zhang L, et al. J Am Acad Dermatol. 2023;doi:10.1016/j.jaad.2023.07.1023.

In this edition, nonalcoholic muscadine wine may improve aging skin; atopic disease risk increases in sexually diverse patients; AI doubles diagnostic accuracy among patients with skin of color and more. Read the full coverage here:

Nonalcoholic muscadine wine may improve aging skin in older women

Atopic disease risk increases in sexually diverse patients

AI doubles diagnostic accuracy of skin conditions among patients with skin of color

Post-acne scarring should be treated as primary skin condition

Histologic margin status can help predict lentigo maligna melanoma recurrence

References:

Christman L. Dealcoholized muscadine wine improved skin health, reduced oxidative stress and inflammation in women in a randomized controlled trial. Presented at: NUTRITION; July 22-25, 2023; Boston. Hoang MP, et al. J Am Acad Dermatol. 2023;doi:10.1016/j.jaad.2023.07.008. Rypka KJ, A, et al. JAMA Dermatol. 2023;doi:10.1001/jamadermatol.2023.1934. Schneider JG, et al. J Drugs Dermatol. 2023;doi:10.36849/JDD.7581. Zhou C, et al. Clin Cosmet Investig Dermatol. 2023;doi:10.2147/CCID.S406235.