Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Healthy aging starts with physical resilience, the body’s ability to withstand and recover from stress. Maile Young Karris, M.D., defines the concept and sets the stage for practical strategies that match real-world needs. Ryan J. Moran, M.D., M.P.H., recommends simple routines such as wall push ups, posture alignment, and chin tucks, and he links posture and vision to fall prevention; social connection helps people stick with movement. Theodore Chan, M.D., F.A.C.E.P., F.A.A.E.M., explains that age alone is a poor predictor of outcomes in acute care and that functional resilience strongly influences decisions. Gail Levine emphasizes accountability, community, and balanced nutrition. Moran highlights protein needs of about 1 to 1.2 grams per kilogram plus calcium with possible vitamin D, and he favors plant focused eating with limited processed foods.

Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40960]

Dr. Rahul Aggarwal presents emerging treatments for advanced prostate cancer, highlighting rapid advances in drug development. He outlines therapies targeting cancer cell surface proteins beyond PSMA, including CD46, B7-H3, and DLL3, and explains how antibody-drug conjugates deliver potent chemotherapy directly to tumors. He also discusses bispecific T-cell engagers designed to trigger immune attacks on cancer cells, including promising results from agents like Talquetamab. Aggarwal explores new isotopes such as actinium-225 for radioligand therapy, which may offer stronger and more durable responses than current treatments. He emphasizes continued innovation in targeting the androgen receptor, with drugs that degrade the receptor or block androgen production more effectively than existing therapies. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40813]

Heather E. Whitson, MD, MHS explores how resilience—the ability to recover and adapt after stress or illness—changes across the lifespan. She explains that bounce back slows with age and that people age at different rates, influenced by biology, lifestyle, and environment. Studies connect lower inflammation, stronger cellular health, and emotional well-being to better recovery, such as regaining mobility after hip fracture or coping with persistent pain. Whitson also highlights how changes in the brain, like the buildup of amyloid and tau proteins, begin years before memory problems, underscoring the importance of early prevention. She points to practical steps that support resilience at any age: staying active, eating a Mediterranean style diet, managing blood pressure and blood sugar, protecting vision, engaging socially and mentally, prioritizing sleep, avoiding harmful exposures, and preventing injuries. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40959]

Scott A. Armstrong, M.D., Ph.D., of the Dana-Farber Cancer Institute, studies how certain aggressive forms of acute myeloid leukemia (AML) develop and survive. His work centers on a protein called menin, which helps leukemia cells keep cancer-promoting genes switched on. Armstrong’s team has found that blocking menin with specially designed drugs can shut down these gene programs, push leukemia cells to mature, and slow or stop the disease in lab models and patients. While some leukemias adapt by developing mutations in menin or finding other ways to survive, his research is revealing why certain genes are especially dependent on menin and how to target them more effectively. These discoveries are now shaping new treatments, drug combinations, and potential strategies for other cancers that rely on similar mechanisms. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40875]

Danielle K. Glorioso, LCSW, explores the complex nature of grief, emphasizing that it is a lifelong, evolving response to loss rather than something to “get over.” She explains the differences between acute grief, integrated grief, and prolonged grief disorder, highlighting how factors like attachment, personal history, and circumstances of death can influence the grieving process. Glorioso outlines how prolonged grief can impair daily functioning and discusses effective treatments, including a structured therapy program that facilitates adaptation. She also examines resilience as a skill that can be strengthened through emotion regulation, cognitive flexibility, social support, and meaning-making. Drawing on both professional expertise and personal loss, Glorioso offers practical strategies for coping, supporting others, and finding hope while honoring the memory of loved ones. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40332]

Dr. Lindsay Hampson discusses urinary incontinence and sexual dysfunction following prostate cancer treatment, emphasizing that both are common and treatable. She explains the different types of incontinence—stress, urge, mixed, and overflow—and outlines how understanding the cause helps guide treatment. Options include pelvic floor physical therapy, medications, surgical interventions like slings or artificial sphincters, and supportive devices. Dr. Hampson also reviews effective strategies for managing erectile dysfunction, such as oral medications, vacuum devices, injections, and penile implants. She highlights the importance of shared decision-making and reassures patients that even small symptoms can significantly affect quality of life and deserve attention. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40814]

Why does amber light ease stress and anxiety? One theory is that it’s similar to the natural orange light experienced in nature, like sunsets and campfires. Thanks to interest and funding in color psychology research, discoveries like this will improve emotional and mental health for everyone, especially those who need it most like hospital patients and those in elder care housing. Series: "UC Davis News" [Health and Medicine] [Science] [Show ID: 41054]

Radiologist Dr. Julian Hong plains how stereotactic body radiation therapy (SBRT) is used to treat oligometastatic prostate cancer—cases where cancer has spread but only to a few limited sites. This approach targets small clusters of metastases with high-dose, image-guided radiation in five or fewer sessions. Hong reviews clinical trial evidence showing that adding focal radiation can improve outcomes, especially when all visible metastases are treated. He highlights the value of modern imaging, like PET scans, in identifying lesions and shaping personalized treatment plans. Studies suggest SBRT offers effective disease control with low toxicity and minimal impact on quality of life, making it a promising option for patients with limited metastatic spread. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40807]

Stanley Chodorow, Emeritus Professor of History at UC San Diego, traces the evolution of food preservation, preparation, and production from ancient times to the modern era. He explores early methods such as drying, salting, and ice cellars, advances like iceboxes, refrigeration, and flash freezing, and innovations in cooking technology from open fires to gas and electric stoves. Chodorow examines the domestication of animals, the development of agriculture, and transformative tools like the wheeled plow and horse harness. He highlights the rise of industrialized food, refrigerated transport, and global trade in products such as sugar, chocolate, and processed foods. Concluding with the health impacts of dietary changes since the shift from hunter-gatherer to agricultural societies, he offers a sweeping view of how technology has shaped what—and how—we eat. Series: "Osher UC San Diego Distinguished Lecture Series" [Health and Medicine] [Science] [Show ID: 40966]