Priyanka and Hari dive into the surprisingly complicated world of drinking water, from tap water safety and filters to spring water, mineral water, and electrolytes. They unpack how water access and quality affect health, why some bottled waters are worth it and others are pure marketing, and what you should really be drinking day to day. Then Hari shares his pickleball injury story, and they discuss what draws people to the growing sport and what people can do to help prevent injuries.

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What is ayahuasca and what happens after the ceremony ends? Priyanka and Hari sit down with physician and plant-medicine guide Dr. Joe Tafur to explore the realities behind one of the world’s most talked-about sacred medicines. From first-time fears and safety concerns to spiritual healing, trauma, and integration, they unpack what ayahuasca is, who it may or may not be for, and why it is not a magic cure. Along the way, they reflect on anxiety, and self-love. This episode offers a grounded look at psychedelics, mental health, and the long, imperfect work of healing.

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Why does laughter feel so good, and why do we need it so much? Priyanka and Hari explore laughter as medicine, social glue, and survival instinct. From the science of Duchenne laughter to the strange magic of laughing in groups, they unpack how laughter can heal even when it is forced, awkward, or imperfect. They also share personal experiences with art therapy and discuss how creativity can help process pain, restore agency, and calm the nervous system.

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Hari and Priyanka talk with double board certified reproductive endocrinologist and infertility expert Dr. Lucky Sekhon, author of The Lucky Egg. Together, they break down the biggest fertility myths and explain what is actually happening inside our bodies, from why orgasm has nothing to do with conception to what IVF really does. They also explore how much men contribute to infertility and the ethics of embryo testing, genetic screening, and so-called “designer babies.” It is a crash course in fertility every adult should hear.

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Why do we drink, even when it harms us? Priyanka and Hari explore our complicated relationship with alcohol, from first drinks to long term habits. Colorectal surgeon and author Dr. Charles Knowles joins them to discuss the research behind his book, Why We Drink Too Much. They examine how alcohol hijacks the brain’s reward system, why some people are more vulnerable to dependency, and the long overlooked risks of moderate drinking. The conversation spans dating culture, marketing myths, and mental health. Dr. Knowles also shares his own journey to sobriety and evidence based approaches to changing drinking behavior, including self compassion, community, and education.

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On this mini episode, Dr. Priyanka Wali does a rapid fire health check to close out the year. She breaks down common symptoms and answers the questions we all worry about. Is it a cold or the flu? What to do when you suspect you have a UTI. What blood in your stool can mean. Why fatigue and anemia often get mixed up. And what to know about headaches, foot fungus, chest pain, dizziness, and blood pressure. This is your practical, no panic guide to the health stuff you want clarity on going into the new year.

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Hari and Priyanka are joined by Science Stuff host Jorge Cham to talk about advances in robotic-assisted surgery, including how robots are already helping surgeons operate with greater precision and what the future of automated surgery could look like. They also explore how artificial limbs are becoming more responsive and humanlike as AI systems learn to better interpret signals from the body. Finally, they dig into the downsides of these technologies, from growing data and energy demands to ethical questions about where AI belongs in medicine and who might be left out as it advances.

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Priyanka and Hari are joined by Dr. Neil Vora, a global health expert who has spent his career fighting infectious diseases around the world. They talk about why human health is inseparable from the health of the environment and nature, what horror movies and TV shows get right about outbreaks, how misinformation and disinformation spread just as fast as viruses, and why we need more imperfect activists. It is a hopeful, clear-eyed conversation about showing up even when we do not have all the answers, staying curious instead of fearful, and remembering that protecting each other and the planet are deeply human acts.

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Hari and Priyanka unpack why some medications may increase your risk of falling, what a new LSD study reveals about anxiety treatment, and the the pros and cons of curling up in bed with your pets.

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Could sunlight be the key to better sleep? Hari and Priyanka talk with science journalist Lynne Peeples about circadian rhythms, light exposure, and simple ways to work with you body's natural clock. As Lynne puts it: "Be clockwise."

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