A career in juggling, organisation and guilt management Professor Helen McShane has been working on a new TB vaccine for 10 years. There are about 9 million new cases and 1.7 million deaths every year from tuberculosis. She developed MVA85A, a vaccine with the aim to boost the cellular immune response induced by BCG. Developing countries are especially in need of a new vaccine since HIV and TB epidemics overlap and show a devastating synergy.