In this episode, we explore the complex world of hematologic malignancies, focusing on leukemia, lymphoma, and multiple myeloma. We’ll break down how these cancers are classified by cell lineage and disease progression, and review key diagnostic tools such as bone marrow biopsy, cytogenetic analysis, and molecular testing. You’ll learn how treatment strategies range from intensive chemotherapy and stem cell transplantation to advanced targeted therapies, including tyrosine kinase inhibitors. Nursing priorities are emphasized throughout, including vigilant prevention of infection and hemorrhage, management of treatment-related toxicities, and monitoring for complications like tumor lysis syndrome. We’ll also address the essential psychosocial and ethical aspects of oncology care—covering patient education, survivorship planning, and principles guiding palliative and end-of-life decision-making. This episode equips nurses with the clinical knowledge and compassionate framework needed to care for patients facing complex blood cancers.