In this episode, we delve into the Italian Wars, a sweeping series of Renaissance-era conflicts fought between 1494 and 1559 that turned the Italian Peninsula into the central battleground for Europe’s great powers. Sparked by French territorial ambitions and a broader rivalry with the Habsburg dynasty, the wars drew in Spain, the Holy Roman Empire, England, and even the Ottoman Empire, while local city-states constantly shifted alliances in a complex struggle for dominance. We explore how these campaigns helped drive a military revolution, as portable firearms and advanced artillery began to reshape warfare, and how the era’s proximity to the invention of the printing press left an unusually rich record of contemporary accounts. The episode concludes with the Peace of Cateau-Cambrésis, which cemented Spanish influence over Italy and forced France to abandon its southern ambitions, redefining the balance of power in early modern Europe.