This is Episode 2: Foundations II — Cranial Nerves, PNI Highways, and the Skull Base.**Last episode, we mapped lymphatics. Today, we map nerves.Because in head and neck oncology, **perineural invasion is not just a pathology word. It is geography.** It is a route problem. When tumor gets into a nerve, it can travel **from a peripheral skin site or gland to the skull base foramina**, and from there into deeper skull base compartments. That is why PNI changes your clinical target volume.