For this episode of Hope in the Pipeline, Dr. Wylie is joined by one of our Clinical Research Coordinators, Jessica Watson. They talk about gastroparesis clinical trials, and Jessica explains what a research trial looks like.

Welcome to the third part of our Hope in the Pipeline series on hypersomnolence disorders. In this episode, we dive deep into:

🔹 Medications used to treat narcolepsy – from older stimulants to newer, longer-lasting options

🔹 The role of antidepressants and sodium oxybate in managing symptoms like cataplexy

🔹 Key differences between narcolepsy and idiopathic hypersomnia (IH)

🔹 Current treatment options for IH and why diagnosis can be so challenging

🔹 Exciting ongoing clinical research at Preferred Research Partners, including a new potential therapy targeting narcolepsy and IH

Welcome back to Hope in the Pipeline! In this episode, we continue our deep dive into narcolepsy, exploring:

Have you ever felt overwhelmingly sleepy even after a full night’s rest? Narcolepsy and idiopathic hypersomnia are two central disorders of hypersomnolence that affect millions worldwide — often undiagnosed.

In this episode of Hope in the Pipeline, we explore:

🧠 What narcolepsy and idiopathic hypersomnia are

🧠 Key symptoms and differences between the two

🧠 Causes, diagnosis, and treatment options

🧠 The role of the immune system in narcolepsy

🧠 How current clinical trials and research are bringing hope for better therapies

Narcolepsy is a lifelong neurological disorder caused by the loss of hypocretin (orexin), leading to uncontrollable sleepiness, cataplexy, and fragmented nighttime sleep. Idiopathic hypersomnia, on the other hand, can leave people excessively sleepy even after 10+ hours of rest. If you or someone you know struggles with unexplained sleepiness, this video will help you understand these conditions and where research is headed. 👉 Don’t forget to like, share, and subscribe to Hope in the Pipeline for more episodes on rare and underrecognized conditions.

Did you know that the number of blood pressure medications you take could be a sign of untreated obstructive sleep apnea?

There is a strong connection between obstructive sleep apnea (OSA) and hypertension, including the serious health risks of untreated OSA—from stroke and dementia to heart failure and even death. In this episode, Dr. Paul Wylie discusses a new clinical trial testing a promising medication designed to treat BOTH sleep apnea and high blood pressure.

✅ Learn the warning signs

✅ Understand the science

✅ Hear how you can make a difference through clinical research

#sleepapnea #hypertension #sleepmedicine #sleepstudy #obstructivesleepapnea

Did you know that 12% of women experience chronic or episodic migraines, and for many, they’re tied to hormonal cycles? In this episode of Hope in the Pipeline, Dr. Paul Wylie dives into the causes, symptoms, and treatments of menstrual migraines.

🧠In this episode, you’ll learn:

What causes menstrual migraines (hint: estrogen & hormone changes)

How they differ from common migraines

Why they often respond poorly to current medications What symptoms to look for, and how to track them

Why clinical trials matter—and how YOU can get involved

💊 About the Clinical Trial:

Open to individuals 18 years and older 18-week study, with the option for a 1-year extension

Medication is taken just 7 days a month to help prevent migraines

Compensation provided, plus free medication during the extension period if it helps

🧪 This trial is testing a promising FDA-approved treatment for menstrual migraines

In this episode of Hope in the Pipeline, Dr. Paul Wylie dives deep into chronic insomnia disorder—what causes it, how it affects both children and adults, and the latest research aimed at treating it.

🧠 Learn about: The types of insomnia symptoms Differences in diagnosing pediatric vs. adult insomnia Behavioral vs. pharmacological treatments The real-life impact of chronic sleep disruption Two new clinical trials are now enrolling participants (ages 10–17 and 18–65) Why your participation could help shape the future of insomnia treatment

📚 Plus: We're giving away 3 copies of Dr. Richard Ferber’s Solving Your Child’s Sleep Problems!

#Insomnia #SleepMedicine #ChronicInsomnia #clinicaltrials #clinicalstudy #sleepresearch

Attention Deficit Hyperactivity Disorder (ADHD) affects millions of children — but early diagnosis and the right treatment can make a world of difference. In this episode of Hope in the Pipeline, Dr. Paul Wylie, Neuropsychiatry and Sleep Medicine Specialist, explores the symptoms, causes, and treatment options for pediatric ADHD.

We also dive into an exciting new clinical research trial for children ages 4 to 5 years and 7 months, testing a non-controlled medication already approved for older children and adults. This trial could help shape the future of ADHD treatment — and eligible families may receive a formal diagnosis and compensation for participation.

Learn how ADHD presents differently in boys and girls, the role of genetics and sleep, and why your child’s struggles might have a biological solution.

📍 Visit PreferredResearchPartners.com to learn more or apply for the study.

🔔 Don’t forget to like, share, and subscribe for more episodes on mental health breakthroughs.

In this episode of Hope in the Pipeline, Dr. Paul Wylie discusses pediatric migraines, their prevalence, symptoms, and treatment options. He highlights the importance of understanding how migraines affect children differently than adults and the potential for clinical trials to improve treatment outcomes. The conversation emphasizes the need for awareness and research in managing pediatric migraines effectively.