Dr. Lawenda advocates for hormone replacement therapy (HRT), emphasizing its benefits beyond menopause symptom relief. The podcasters discuss his FaceBook post that highlights the early onset of hormonal changes in women's 30s and 40s, advocating for early intervention via targeted testing and personalized HRT. He details various FDA-approved and compounded HRT options, including estrogen and progesterone therapies, addressing the Women's Health Initiative controversy and emphasizing the importance of timing and individual needs. Finally, he discusses testosterone replacement therapy (TRT) for women and outlines contraindications for HRT.