In our final episode of the series, Kiruthikah and Llywelyn are joined by Dr. Alex Georgiou, consultant medical oncologist at Guy’s and St. Thomas’, to discuss the rapid advancements in lung cancer treatment and what they mean for patients and clinicians.

Alex shares insights on:

• how neoadjuvant and adjuvant immunotherapy are transforming early-stage lung cancer treatment
• the role of liquid biopsies in expediting genomic testing and guiding treatment decisions
• emerging innovations, including bispecific antibodies and mRNA cancer vaccines.

Listen in to explore the latest breakthroughs in lung cancer care and how evolving research is shaping the future of diagnosis and treatment.

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In this episode, Kiruthikah and Llywelyn are joined by Dr Emma Beddowes, consultant medical oncologist at Guy’s and St. Thomas’ NHS Trust, to discuss the latest developments in breast cancer treatment, from early-stage interventions to metastatic care.

Emma shares insights on:

• how immunotherapy is transforming outcomes in triple-negative breast cancer
• the emerging role of circulating tumour DNA in guiding treatment decisions
• the impact of exercise and lifestyle factors on breast cancer survival.

Listen in to explore the cutting-edge advances shaping breast cancer care and what’s on the horizon for patients and clinicians alike.

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In this episode, Kiruthikah and Llywelyn are joined by Dr Miguel Ferreira, consultant clinical oncologist, clinician scientist at King’s College London and NIHR Research Delivery Network cancer lead.  

In this episode, Miguel discusses the current landscape of head and neck cancer treatment and the emerging role of the gut microbiome in cancer treatment including

• the critical connection between gut health and cancer development
• how differing microbial profiles across populations affect outcomes
• Miguel’s own original research looking at specific bacteria in head and neck cancers.

Listen in to discover how advancing microbiome research is reshaping cancer treatment and paving the way for personalised therapeutic strategies.

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In this episode, Kiruthikah and Llywelyn are joined by Dr Nirupa Murugesu, Principal clinician for Cancer Genomics and clinical studies at Genomics England and consultant medical oncologist. 

Nirupa shares insights from her work on the 100,000 Genomes Project and discusses how genomic data is transforming cancer care. This episode explores:

• the integration of whole genome sequencing into routine NHS practice
• equity in access to cutting-edge genomic testing and therapies
• how circulating tumour DNA and AI-driven tools are shaping the future of oncology.

Listen in to discover how genomics is redefining cancer diagnostics, treatment pathways, and patient outcomes.

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In this episode, Kiruthikah and Llywelyn are joined by Dr. Julien de Naurois, a consultant medical oncologist specialising in colorectal cancer at Guy’s and St. Thomas’.

Julian shares insights into the evolving trends in lower GI cancers, with a particular focus on the rising incidence of early-onset colorectal cancer.

This episode explores:

• the potential factors driving increased cases in younger patients
• the importance of tailored, multi-professional support for younger patients
• updates on innovations like liver transplantation for metastatic colorectal cancer and the latest in systemic and immunotherapy treatments.

Listen in to learn how these advancements are shaping the future of lower GI cancer care.

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In this episode, Kiruthikah and Llywelyn are joined by Dr Debra Josephs and Linda Gomm. Debra is a medical oncologist and clinical lead for advanced therapies, while Linda is an Advanced Nurse Practitioner – Cell Therapy/Early Phase Trials, both at Guy's and St. Thomas' NHS Foundation Trust.

Debra and Linda talk us through the future of cell therapies, covering the latest advances in ATIMPs for solid tumours. This includes:

• the differences between CAR T-cell and TIL therapies
• practical challenges in setting up cell therapy services
• handling toxicities and required expertise for these advanced treatments.

Listen in to learn how these emerging treatments are reshaping cancer care.

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In this episode, Kiruthikah and Llywelyn are joined by Dr Yin Wu. Yin is an honorary consultant medical oncologist at Guy's and St Thomas' NHS Foundation Trust and a clinician scientist at King's College London.

Yin talked to us about the current landscape of melanoma treatment, novel targets as well as his own career path and research interests as a melanoma academic. 

This includes 

• the biomarkers and associated therapies used for advanced melanoma
• novel therapeutics in melanoma management 
• the potential of microbiome manipulation and adoptive cell therapy.

Listen in to discover how these innovations are enhancing melanoma care.

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