Your brain can be drifting in the wrong direction long before you notice a single memory slip, and that’s the scary part of cognitive decline. We sit down with physician-neuroscientist Dr Christin Glorioso, CEO of NeuroAge, to get concrete about brain aging, Alzheimer’s risk, and what prevention actually looks like when you stop relying on vibes and start relying on data. 

We talk about why genetics like APOE4 matter, why they’re not destiny, and how lifestyle still drives a huge part of dementia risk. Dr Christin explains how brain age can be measured using a combination of brain MRI (including shrinkage in key regions like the hippocampus), online cognitive testing, and blood biomarkers that reflect core mechanisms of brain aging like synapse health, mitochondrial function, inflammation, and DNA damage. A big theme is timing: cognition is a lagging indicator, so waiting until you “feel off” often means you’re already late. 

We also get practical about interventions that move the needle. We dig into exercise that supports memory regions (including why HIIT can be uniquely helpful), why VO2 max is an underrated brain-health metric, and how sleep, stress, and community can be the missing links for high performers. Finally, we clear up the lithium conversation: lithium orotate vs lithium carbonate, what the human evidence actually supports, and why supplement stacks and polypharmacy can quietly work against you. 

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