The Longevity Loop Podcast

Dr. Aleksandra Gajer spent 10 years in the ER before moving into prevention. She and Brent cover what to do first when you hit midlife, feel off, and your blood work looks fine. If you are 40 to 60 and tired of treating health like a shopping cart, this gives you a clear order of operations.

What you'll hear in this episode
Why she left the ER: the same chronic disease patients kept coming back sicker
What she checks first (metabolic health, inflammation, hormones) and why high insulin blocks fat loss
Her budget answer: build your foundations and move every day
Spotting hormone-related fatigue and mood changes in women and men
Why she stays on bioidentical hormones, and when she would rethink treatment
Her view on peptides, and the screening she does first
How AI and wearable data may personalize care
Why real food and colorful plants beat a supplement stack

Guest
Dr. Aleksandra Gajer is an emergency-trained physician who leads The Gajer Practice in Northern Virginia. She trained at the University of Maryland and George Washington University, then spent 10 years in the ER. She focuses on metabolic health, hormones and longevity, sees patients in Virginia, Maryland and DC, offers telemedicine coaching in other states, and teaches clinicians about peptide medicine.

Links and resources mentioned
Dr. Gajer
The Gajer Practice: https://thegajerpractice.com
Free intro call: https://thegajerpractice.as.me/free-intro-call
Instagram: https://www.instagram.com/thegajerpractice
Clinician peptide courses: https://thegajerpractice.com/clinician-peptide-education
Mentioned in the episode
Bryan Johnson, Blueprint: https://blueprint.bryanjohnson.com
The Doctor's Kitchen, Dr. Rupy Aujla: https://thedoctorskitchen.com
Stanford aging study (ages 44 and 60), likely the source of Brent's "aging cliffs": https://www.nature.com/articles/s43587-024-00692-2 [VA: verify this detail]
Friendly clarifications
Dr. Gajer said people rarely lived past 45 until recently. Past averages look low mostly because many children died. Adults in hunter-gatherer groups often lived into their late 60s and 70s: https://doi.org/10.1111/j.1728-4457.2007.00171.x
She said the black box warnings on estradiol and testosterone were removed. Only part of each was: testosterone lost its cardiovascular language and gained a blood pressure warning (https://www.fda.gov/drugs/drug-alerts-and-statements/fda-issues-class-wide-labeling-changes-testosterone-products), and estrogen-only products keep the endometrial cancer warning (https://pubmed.ncbi.nlm.nih.gov/41687116/).
She said BPC-157 should come from a compounding pharmacy. It is not FDA approved, and a July 2026 FDA panel vote to recommend compounding it is advice only: https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks [VA: verify this detail]
She said peptides need not be metabolized by the kidneys. Many small peptides are cleared there: https://www.eurekaselect.com/article/90794 [VA: verify this detail]

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Looking for a vetted longevity clinic or practitioner? Spannr.com is the most comprehensive longevity directory on the internet. Brent is the Owner and Publisher. (https://spannr.com)

Disclaimer
Disclaimer: The Longevity Loop is for educational and entertainment purposes only and does not constitute medical advice. Brent Wallace is not a physician, and nothing shared on this channel should be taken as a diagnosis, treatment, or prescription. The host and guests share personal experiences, opinions, and general information about longevity and precision medicine. Always consult a qualified healthcare professional before making any changes to your diet, supplements, medications, exercise, or health protocols. Any protocols, products, or practices discussed are shared for informational purposes and reflect individual results that may not apply to you.
This channel may contain affiliate links, and we may earn a commission on qualifying purchases at no extra cost to you. Some products featured may be sponsored, gifted, or provided free of charge, and some segments may be paid promotions. We only share products and services we believe add value, and all opinions remain our own.
Guest opinions are their own and do not necessarily reflect those of the host, The Longevity Loop, Longevity Clinic Marketing, or Spannr.com. By watching, you acknowledge that you are responsible for your own health decisions.

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Dr. Michael J. Hall: What Actually Earns a Spot in Your Protocol

Episode Summary

Brent Wallace speaks with Miami Beach longevity physician Dr. Michael J. Hall, author of *Infinite Youth: Solving the Aging Equation*, about what deserves a place in a longevity protocol. They examine supplement hype, rapamycin, methylene blue, growth hormone, resveratrol, and why sleep, nutrition, and movement come first.

What You'll Hear

- How Dr. Hall weighs clinical evidence and before-and-after labs over trends, and why he considers many supplements a waste.
- Vitamin D dosing and sun exposure. Note: Adult RDA is 600 IU (800 IU over 70); 400 IU applies to infants.
- Rapamycin's possible biomarker effects, with no proven human lifespan extension.
- His "heliotropic" approach: light breakfast, protein at midday, root vegetables at dinner; plus 10–12 deep squats before meals.
- Why he cautions against refined white flour, sugar, and rice.
- His personal COVID experience with methylene blue, not a treatment recommendation.
- His "Aging Funnel": foundational habits before peptides or supplements, plus managing wearable anxiety, longevity fatigue, and recovery.
- How an ophthalmology residency dispute led him toward family medicine, New Zealand's health system, and preventive care.
- His top three: sleep, nutrition, movement.

Meet the Guest

Dr. Michael J. Hall, MD, MSc, is a board-certified physician, Senior FAA Aviation Medical Examiner, and founder of Hall Longevity Clinic in Miami Beach (established 2006). His background includes ophthalmology training at New York Hospital/Cornell, a master's in healthcare management and law from NYU, and family medicine. His patients have included entertainers and professional athletes. He is developing WellSkor, a dashboard combining labs and wearable data.

Guest Links

- Clinic: https://hallongevity.com
- Bio: https://hallongevity.com/about
- Book (paperback): https://www.amazon.com/Infinite-Youth-Solving-Aging-Equation/dp/B0H486YDD3
- Book (Kindle): https://www.amazon.com/Infinite-Youth-Solving-Aging-Equation-ebook/dp/B0H9JPFM75
- WellSkor: [Sign-up link to verify]
- Contact: [email protected] | 866-937-4255 [Verify]

Research and Context

- TRIIM, Fahy et al. (2019), growth hormone/DHEA/metformin and thymus/epigenetic-age findings in a small trial: https://onlinelibrary.wiley.com/doi/10.1111/acel.13028 [Verify zinc mention]
- PEARL, low-dose rapamycin (2025), 48-week safety and selected functional outcomes, not lifespan: https://www.aging-us.com/article/206235/text [Confirm this is Dr. Hall's study]
- NIH vitamin D guidance: https://ods.od.nih.gov/factsheets/vitamind-consumer/
- Consumer Reports, phthalates in kids' snacks: https://action.consumerreports.org/nb-20260826-anniescheddarbunnies [Find main article]
- Calorie restriction: CALERIE and NIA/Wisconsin primate studies [Add sources]. Human lifespan extension is not established.
- Methylene blue and light for COVID [Research link needed]. Evidence is limited; interactions are possible.
- Resveratrol/Sirtris: GSK bought Sirtris for $720M in 2008; its site closed in 2013. https://www.fiercebiotech.com/biotech/gsk-buys-sirtris-for-720m | https://newrepublic.com/article/112706

Other Mentions

XYMOGEN: https://www.xymogen.com

Also discussed: Thorne, Pure Encapsulations, Ortho Molecular Products, GI-MAP, CellCore, Oura Ring, WHOOP, David Sinclair, Peter Attia [name to verify], the French paradox, Blue Zones, Hippocrates' disputed "food is medicine" quote, and Wills Eye Hospital [name to verify].

Films: Forever Young (2025): https://tv.apple.com/us/movie/umc.cmc.4t1561uviumw4ofcri0ufql7v ; Elysium (2013).

Spannr.com

Find a vetted longevity practitioner: https://spannr.com — owned and published by Brent Wallace.

Disclaimer

The Longevity Loop is for education and entertainment, not medical advice. Brent is not a physician. Experiences, opinions, studies, and protocols discussed are not diagnoses, prescriptions, or guarantees of results. Consult a qualified healthcare professional before changing medications, supplements, diet, or exercise. Individual outcomes vary.

Affiliate links or sponsored, gifted, or paid placements may appear; commissions may be earned at no extra cost. Opinions are those of the speakers, not necessarily The Longevity Loop, Longevity Clinic Marketing, or Spannr. You are responsible for your health decisions.

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Sanjiv Lal spent twenty years building pharmaceutical, diagnostic, and laboratory companies. Then at forty, he became the patient, and the system he helped build told him to manage his decline.
In this episode, Brent talks with Sanjiv about what happened next, and about the peptide boom nobody is explaining honestly. They get into what peptides actually are, why the FDA is reconsidering its restrictions on roughly nineteen of them, and what's really inside the vials people buy online.

You'll hear about:
- What it's like to become a patient inside the industry you built your career in
- Why the future of regenerative medicine might be the signals cells send, not the cells themselves
- Which peptides have real evidence and which ones people are taking on faith
- The honest risk of gray-market "research use only" compounds
- How a clinic decides what goes on its menu, and the red flags to walk out on
- What to do about all of this on a normal budget

Guest: Sanjiv Lal, pharmaceutical scientist, co-founder of RegenTherapy and Cell Factors, and Chief Innovation Officer at Beverly Hills Rejuvenation Center.

Links:
cell.health
regentherapy.com
linkedin.com/in/sanjiv-lal-456985149
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Disclaimer:
This podcast is for educational purposes only and is not personal medical advice, diagnosis, or treatment. Nothing in this conversation creates a clinician-patient relationship. Always work with your own licensed clinician before making decisions about your health.

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#longevity #biohacking #antiaging #healthoptimization

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Episode summary

Dr. Quinto Pauletti joins Brent Wallace to discuss a challenge he sees in high-performing executives: some have neglected their health for years, while others have accumulated mountains of health data without knowing what it means. His approach starts with the fundamentals, then looks for missing pieces through health history, testing, wearables, lifestyle, oral health, and other tools.

For people in their 40s and 50s trying to optimize everything at once, the takeaway is simple: more testing and more biohacks are not always the answer. Sometimes the next step is rebuilding the foundation first.

What you'll hear in this episode

• The two high-performer profiles Dr. Pauletti commonly sees: the burned-out executive and the health optimizer overwhelmed by data.
• Why adding cold plunges, saunas, hard training, and other stressors can backfire when someone is already depleted.
• Why sleep, diet, exercise, hydration, stress management, sunlight, prayer, and meditation remain foundational.
• How Biostrap, HRV, Oura, WHOOP, and CGMs can add useful context without letting data become noise.
• Why oral health, biological dentistry, CBCT imaging, root canals, extraction sites, and amalgam fillings enter the longevity conversation.
• Dr. Pauletti's “Triad of Health”: structure, chemistry, and emotional stress.
• His Missing Link Protocol: calm, clear, then challenge/optimization.
• His take on full-body MRI screening, cold plunges, CGMs, and executive physicals in Brent's “Loop Filter.”

Guest

Dr. Quinto Pauletti, DC, is a chiropractor and executive health practitioner based in Pennsylvania. He holds a BS in Human Nutrition, Foods, and Exercise from Virginia Tech and a Doctor of Chiropractic degree from Palmer College of Chiropractic. His work focuses on executives and entrepreneurs using health history, testing, lifestyle assessment, and wearable data.

Credential note: Public professional sources identify Dr. Pauletti as a DC, Doctor of Chiropractic, rather than an MD or DO.

Links and resources mentioned

Doc-Q — Dr. Pauletti's executive health practice:
https://doc-q.com/

Running on Empty at the Top — Dr. Pauletti's upcoming book:
https://runningonemptybook.com/

Biostrap — wearable and HRV monitoring platform:
https://biostrap.com/

Oura Ring: https://ouraring.com/

WHOOP: https://www.whoop.com/

Function Health: https://www.functionhealth.com/

Bryan Johnson / Blueprint: https://blueprint.bryanjohnson.com/

Dr. Daniel Pompa: https://drpompa.com/

IABDM biological dentist directory:
https://iabdm.org/location/

Dr. Dominik Nischwitz (“Dr. Dome”):
https://linktr.ee/dr.dome

Applied Kinesiology: https://www.icak.com/

Neuro Emotional Technique: https://www.netmindbody.com/

Quantum Neurology: https://www.quantumneurology.com/

Root Cause Protocol: https://therootcauseprotocol.com/

John Wooden’s “basics first” story:
https://newsroom.ucla.edu/magazine/john-wooden-tie-shoes-teaching-basketball

Evidence notes

Dr. Pauletti discusses jaw “cavitations” or NICO as possible hidden sources of chronic infection. Evidence in this area remains disputed, with reviews noting limited-quality evidence and a lack of accepted diagnostic standards.

He also discusses CBCT imaging and amalgam fillings. Current dental guidance recommends CBCT based on clinical need rather than routine use. The FDA does not recommend removing intact amalgam fillings solely to prevent disease when there is no decay or medical reason for removal.

Whole-body MRI screening also comes up in the Loop Filter. Research suggests it can detect abnormalities in asymptomatic people, but incidental findings, inconsistent protocols, and limited long-term outcome data remain important limitations.

Spannr.com

Looking for a vetted longevity clinic or practitioner? Spannr.com is a longevity directory owned and published by Brent Wallace.
https://spannr.com/

Disclaimer

The Longevity Loop is for educational and entertainment purposes only and does not constitute medical advice. Brent Wallace is not a physician. Nothing shared should be taken as a diagnosis, treatment, or prescription. Always consult a qualified healthcare professional before changing your diet, supplements, medications, exercise, or health protocols.

This channel may contain affiliate links, sponsorships, gifted products, or paid promotions. Guest opinions are their own and do not necessarily reflect those of the host, The Longevity Loop, Longevity Clinic Marketing, or Spannr.com.

 Watch the video version: youtube.com/@TheLongevityLoop

Think you're ready to revolutionize your clinic's first impression?

Let's chat about some strategy!

Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation.

We're here to help you shine from the moment patients reach out!

We talk with Dr Ron Primas about what actually improves healthspan when you strip away expensive hype and focus on the basics that work. We dig into prevention, training, testing, and the social support that helps people stay resilient as they age. 
• Lessons from caring for ultra-wealthy patients, including why money does not replace sleep, exercise, nutrition, and fasting 
• Why social support and built-in care teams can extend functional years in extreme old age 
• The Manhattan bubonic plague case, how it presented, and why catching it early matters 
• Health literacy in Harlem, food deserts, and the Good Food in the Hood approach to changing what stores stock 
• The three Es of preventive medicine: engineering, education, enforcement 
• Why concierge medicine grew from insurance reimbursement pressures and the need for time-intensive prevention 
• How longevity medicine overlaps with preventive medicine and why safety and fall prevention still count 
• Intrinsic capacity as a real-world measure: grip strength, sit-to-stand, walking tests, cognition, mood 
• Epigenetic clocks and other aging tests as motivation tools, plus which basic labs matter most 
• Strength training as the key lever, with zone 2 and HIIT to support VO2 max 
• Dr Primus’ routine: full-spectrum light, training split, Norwegian 4x4, lactate-guided zone 2, fasting adjustments 
• Ancestral eating, fiber-rich tubers, and the role of organ meats in nutrient density 
• Where to learn more: drprimus.com and a4li.org 
share it with someone else, you know, especially if someone's in their 40s, 50s. subscribe so you don't miss your next longevity loop, and we'll see you there.

 Watch the video version: youtube.com/@TheLongevityLoop

Think you're ready to revolutionize your clinic's first impression?

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We're here to help you shine from the moment patients reach out!

You can buy a “longevity stack” in 30 seconds, but you can’t buy your way around biology. Today we sit down with Sergei Yakimov, a longevity-focused VC who has reviewed thousands of companies and only funded a handful, to unpack what actually earns conviction when real money and real outcomes are on the line.

We dig into the difference between evidence-based biotech and consumer longevity hype: why clinics, stem cell storefronts, peptide trends, and easy app plays often fail the defensibility and data test, and why serious teams obsess over focus, endpoints, and a realistic FDA and clinical trials roadmap. Sergei also explains why venture capital is still educated guesswork, why “smart money” can be an absurd label, and how “fake it till you make it” collapses once new data packages have to survive external scrutiny.

Then we go bigger: the influencer marketing engine and the human craving for shortcuts, why “aging is a disease” works as a catchy narrative but breaks down under measurement and trial design, and a more practical framework for longevity that targets the barriers that cause premature death disease by disease. We also get hands-on with what helps right now, from biomarker tracking to at-home blood testing that removes friction, plus a rapid-fire filter on resveratrol, NMN, senolytics, and plasma exchange.

If you care about healthspan, biotech investing, and cutting through longevity misinformation, hit subscribe, share this with one person who loves a shortcut, and leave a review with the single idea you’re changing after listening.

 Watch the video version: youtube.com/@TheLongevityLoop

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We're here to help you shine from the moment patients reach out!

Biohacking for longevity often hits a wall because critical pieces are missing from your daily routine. Learn to identify the silent gaps stalling your progress.

Most people approach health optimization with a incomplete checklist. Dr. Thomas and Brent examine why standard wellness protocols frequently fail to deliver the expected results. By analyzing the overlooked factors in physical and mental performance, this conversation highlights exactly why your current habits might not be yielding the vitality you expect.

Whether you are a newcomer or a dedicated biohacker, this session provides a practical framework to audit your lifestyle. We focus on the nuance of healthy aging, moving past surface-level advice to address the foundational elements required for true system efficiency.

Subscribe for weekly longevity breakdowns, and let us know in the comments which health optimization topic you want us to cover next.

#longevity #biohacking #antiaging #healthoptimization

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Want to go deeper into the science behind these conversations? David Donnelly's new course The Long Game covers 21 modules of longevity science with a real-world toolkit for better health decisions. Use code SPANNR for 25% off (brings it from $295 to $221): 

https://foreveryoung.thinkific.com/products/courses/thelonggame?ref=137f61

 Watch the video version: youtube.com/@TheLongevityLoop

Think you're ready to revolutionize your clinic's first impression?

Let's chat about some strategy!

Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation.

We're here to help you shine from the moment patients reach out!

We talk with Dr. Jean Huddleston about what actually goes wrong in hospitals and why the biggest risks are often the quiet “misses,” not the dramatic mistakes. We also share practical ways to spot deterioration early, ask better questions, and advocate for the care we would want for our own family. 
• why “commission” errors are a small slice of patient harm 
• the “nurse worry factor” and why bedside intuition predicts decline 
• two simple deterioration rules to trigger escalation 
• why Mayo built a 100% mortality review and what it changed 
• raw mortality versus adjusted metrics and why the difference matters 
• AI-assisted case review that saves human time without replacing judgment 
• the iceberg of omissions: missed diagnoses, delayed tests, untreated symptoms 
• stopping the “freight train” with goals-of-care conversations 
• full code, DNR, and using plain language for informed consent 
• the Loved One Lens as a reality check for “oh but” excuses 
• family advocacy tactics: bring meds, record talks, correct handoff errors 
• when asking for a second opinion helps and when it backfires 
• rapid response teams and whether families can call them 
• what longevity data is useful in an acute admission and what is not 
• preparing to advocate for parents before the crisis hits 

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Subscribe to the podcast just so you don’t miss the next loop episode. 

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Think you're ready to revolutionize your clinic's first impression?

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We're here to help you shine from the moment patients reach out!

We challenge the biggest misconceptions about GLP-1 medications and explain why many “side effects” are really caused by dosing, behavior, and lack of guidance. We connect semaglutide and tirzepatide to metabolic health, dopamine, and longevity, then lay out a practical framework for using them with better results and less shame.
• why GLP-1 side effects often come from misuse and poor education
• how Bracca pivots from emergency medicine to IV Drips and then HelloDose
• what “food noise” feels like and why quieting it changes behavior
• the reward system, dopamine, and the pause between craving and action
• why Bracca calls GLP-1s “longevity drugs” through insulin and glucose control
• metformin comparison and why GLP-1s feel like a newer tool
• microdosing for longevity goals and using a CGM for feedback
• the DROP method: dose, real-time feedback, own habits, pause factor
• sex drive concerns and why extreme cutting is the real risk
• why people regain weight, body set point, and why tapering matters
• muscle loss myth and why resistance training and creatine matter
• how HelloDose works: virtual consults, shipped prefilled syringes, coaching support
Share it with someone who might be curious about this or curious about longevity in general.

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Think you're ready to revolutionize your clinic's first impression?

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We're here to help you shine from the moment patients reach out!

Your annual physical can tell you that you’re “healthy,” while completely failing to answer the question most of us actually care about: am I aging well. Brent Wallace sits down with Cole Kirschner, co-founder and CEO of Age Rate, to unpack the gap between disease detection and true longevity tracking and why “not sick” is not the same thing as being on a great healthspan trajectory. 

We get into epigenetics and DNA methylation, the science behind modern epigenetic clocks, and why biological age testing can reveal long-term signals that standard blood work often misses. Cole explains how Age Rate turns thousands of methylation data points into actionable categories like chronic inflammation, metabolic health, immune health, cognitive resilience, and frailty resilience, plus lifestyle exposure scores that can reflect tobacco smoke or alcohol history. Brent shares real-world context from years of biomarker tracking, including how a single hard workout can spike CRP and why longer-horizon signals can matter for prevention. 

We also talk about accuracy, validation, and trust, including how some exciting metrics never make it into the report if they fail reproducibility checks. Looking ahead, Cole lays out where longevity tech is going next: AI-driven insights, multi-omics, wearable data integration, and better “now what” guidance so results lead to meaningful change instead of confusion. If you’ve ever wondered whether you should get a biological age test, how to interpret a disappointing number, or what to discuss with a clinician afterward, this conversation gives you a grounded starting point. 

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