Your Genes by Design

How Your Genes Impact Overnight Glucose Regulation and Sleep Patterns After 45


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If your morning glucose feels higher than expected — or your energy shifts dramatically depending on how well you slept — this episode will help connect the dots. In the final episode of the Glucose & Insulin by Design series, Lauri breaks down how sleep, cortisol, and genetics work together to shape your overnight glucose rhythm.

You’ll learn how:

  • Nighttime cortisol affects your morning glucose
  • Sleep stages influence insulin sensitivity and recovery
  • Midlife hormone changes reshape your stress rhythm
  • Key genes like COMT, IL6, SOD2, and PPARGC1A impact overnight repair and energy
  • Simple shifts can support a steadier morning pattern

This episode is especially helpful if you’ve noticed the “wired at night, sluggish in the morning” cycle, early-morning glucose spikes, or changes in how your body responds to stress and sleep after 45.


View the first article in "The Midlife Genomics" series, Genetics vs. Genomics: The Difference — and Why It Matters After 45

Visit my website at inspiredlivingforwomen.com to find out more about me and what I do.


If you’ve ever looked at lab results and felt like they didn’t fully explain what was happening in your body, you may find this helpful.

Download the free guide When “Normal” Lab Results Don’t Feel Normal, which explains how genomics adds context to bloodwork, hormone panels, and other health tests by showing how genes influence the body’s underlying processes.

Download the guide


This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

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Your Genes by DesignBy Lauri Wakefield