Your Genes by Design

If cognition feels different than it used to and focus feels less steady at times, this episode can help explain why.

You’ll learn how:

• Cognitive patterns are influenced by genetics, not just age
• Hormonal shifts affect memory, focus, and stress tolerance
• Mitochondrial efficiency plays a bigger role in mental clarity after 45
• Key genes like APOE, COMT, SOD2, and PPARGC1A shape energy use, inflammation, and cognitive resilience
• Practical, biology-aligned support can improve clarity without extremes or overcorrection

This episode is especially helpful if you’ve noticed mental fatigue, word-finding issues, sensitivity to stress or poor sleep, or clearer patterns tied to movement, food, or daily rhythm. Or if these experiences have always been part of your life but feel harder to ignore now.

Visit my website at inspiredlivingforwomen.com to learn more about me and the work I do.

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

If digestion feels different than it used to — foods sitting heavier, more bloating, stronger reactions to stress, or less tolerance for certain fibers — this episode helps explain why.

This episode explores how gut health has always been shaped by your genes, and why those patterns often become more apparent after 45 as hormonal, microbial, and digestive supports shift.

You’ll learn how:

• Gut health is influenced by genetics 
• Hormonal changes affect motility, microbiome balance, and digestive comfort
• The microbiome becomes more sensitive to stress, sleep, and medications after 45
• Key genes like FUT2, BCMO1, and ADRB2 shape food tolerance, gut lining support, and stress-related digestion
• Simple, biology-aligned strategies can support digestion without extremes or restriction

This episode is especially helpful if you’ve noticed bloating, slower digestion, food sensitivities, stress-related gut symptoms, mixed results from probiotics after 45. Or maybe some of these patterns have always been present but feel harder to ignore now.

Visit my website at inspiredlivingforwomen.com to learn more about me and the work I do.

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

If your sleep feels lighter, your mood responds differently to stress, hot flashes seem unpredictable, or foods and supplements affect you in new ways, this episode helps explain what’s happening.

This episode explores how estrogen behaves after 45 — not simply as a hormone that declines, but as one that shifts roles — and why genetics play a key role in how those changes are experienced.

You’ll learn how:

• Estrogen influences more than reproduction, including inflammation, glucose balance, circulation, and stress response
• Hormone shifts change how receptors, detox pathways, and cortisol interact after 45
• Three key biological shifts make hormone patterns feel more noticeable in midlife
• Genes like ESR2, CYP1B1, SHBG, and COMT shape sensitivity, stability, and stress tolerance
• Simple, consistent foundations support estrogen metabolism and hormone balance without extremes

This episode is especially helpful if you’ve noticed fluctuating energy, changing stress tolerance, mixed hormone signals, or increased sensitivity to foods, supplements, or environmental triggers after 45.

To learn more about the work behind this podcast, visit inspiredlivingforwomen.com

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

If you’ve noticed that caffeine, alcohol, supplements, stress, or even fragrances affect you differently than they used to, this episode will help explain why.

In this episode, Lauri explores how detox and methylation pathways work behind the scenes — and why these systems can feel more noticeable after 45 as hormones and genetics interact differently than before.

You’ll learn how:

• Detox and methylation function as daily biological systems, not cleanses
•  Estrogen changes increase the importance of detox pathways in midlife
•  Stress chemistry places added demand on clearance pathways
•  Key genes like COMT, GSTM1, MTHFD1, and NAT2 shape tolerance and recovery
•  Simple, consistent habits support detox without extremes

This episode is especially helpful if you’ve experienced increased sensitivity to caffeine or alcohol, stress that lingers longer, stronger reactions to supplements, or changes in sleep quality after 45.

Resources Mentioned:

View the Midlife Genomics Series — a six-part article series explaining what genomics is and how to understand your own results.

Visit my website at inspiredlivingforwomen.com to learn more about me and my work.

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

If your morning glucose feels higher than expected — or your energy shifts dramatically depending on how well you slept — this episode will help connect the dots. In the final episode of the Glucose & Insulin by Design series, Lauri breaks down how sleep, cortisol, and genetics work together to shape your overnight glucose rhythm.

You’ll learn how:

• Nighttime cortisol affects your morning glucose
• Sleep stages influence insulin sensitivity and recovery
• Midlife hormone changes reshape your stress rhythm
• Key genes like COMT, IL6, SOD2, and PPARGC1A impact overnight repair and energy
• Simple shifts can support a steadier morning pattern
  
  

This episode is especially helpful if you’ve noticed the “wired at night, sluggish in the morning” cycle, early-morning glucose spikes, or changes in how your body responds to stress and sleep after 45.

View the first article in "The Midlife Genomics" series, Genetics vs. Genomics: The Difference — and Why It Matters After 45

Visit my website at inspiredlivingforwomen.com to find out more about me and what I do.

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

If your energy feels unpredictable — steady one day, wired or restless the next — stress chemistry could be the reason. In this episode of Your Genes by Design, we look at how cortisol responds to everyday pressure, why that response changes after 45, and how your COMT type shapes the way your body clears stress signals and resets.

You’ll discover how:
• Cortisol frees up glucose any time your brain senses pressure
• Slow or prolonged stress chemistry can keep glucose elevated
• Estrogen fluctuations after 45 make stress responses feel less predictable
• COMT influences how quickly you recover after stress
• Daily patterns — like 3 a.m. wakeups, evening alertness, or carb cravings — reflect your stress-glucose rhythm

You’ll also learn practical, gene-informed ways to support your natural rhythm based on your COMT variant — whether your system needs more transitions, more structure, or more intentional reset moments throughout the day.

If you don’t yet know which gene variants you have or how to find out, I’ll be publishing a three- to four-part series in my Your Genes by Design newsletter on Substack that explains how these genes work, what they influence, and how to start exploring your own results. I’ll link to it in the show notes.

If you’ve been wondering why stress, sleep, or energy feel different after 45, this episode connects the dots between cortisol, COMT, hormones, and glucose balance — helping you work with your biology, not against it.

Follow Your Genes by Design for short, science-based insights made practical for real life after 45.
 And if it resonates, please share it with another woman who might benefit.

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

If your energy feels unpredictable — steady one day, scattered the next — cortisol could be the reason. In this episode of Your Genes by Design, we explore how cortisol sets your body’s daily rhythm, why that rhythm often shifts after 45, and how your genetic makeup influences recovery, metabolism, and glucose control.

You’ll discover how:
• Cortisol acts as the body’s natural rhythm regulator
• Chronic stress can flatten the daily energy curve
• Midlife hormone shifts amplify spikes and crashes
• Genes like COMT, IL6, SOD2, and PPARGC1A affect stress recovery, inflammation, and fuel balance
• Everyday signals reveal when your cortisol rhythm is drifting off track

You’ll also learn practical, gene-informed ways to steady mornings, calm evenings, and restore a more natural flow to your day.

If you don’t yet know which gene variants you have or how to find out, I’ll be publishing a three- to four-part series  in my Your Genes by Design newsletter on Substack that explains how these genes work, what they influence, and how to start exploring your own results. 

If you’ve been wondering why stress feels different after 45, this episode connects the dots between cortisol, genetics, hormones, and glucose balance — helping you work with your biology, not against it.

Follow Your Genes by Design for short, science-based insights made practical for real life after 45.
And if it resonates, please share it with another woman who might benefit.

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

Energy isn’t just about what you eat — it’s about how easily your body switches between glucose and fat for fuel. In this episode, we explore metabolic flexibility — the ability to shift between fuel sources — and why that flexibility becomes more important after 45.

You’ll hear how genes like PPARGC1A, FADS1, FADS2, and ADIPOQ shape insulin sensitivity, energy stability, and how efficiently your cells use the fuel you already have.

If you’ve noticed more hunger between meals, afternoon dips, or less steady energy than before, this short episode helps you understand why those changes happen — and what they reveal about your unique design.

Please share this episode with other women 45+ if you think they'd benefit from it.

🎧 Explore the free resource mentioned in this episode — The Oxygen Connection — for practical ways to support your energy system and balance glucose naturally.

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

Feeling steady energy isn’t luck — it’s the result of how efficiently your cells use oxygen to turn fuel into power.
 In this episode, we trace the path from breath to mitochondria to blood sugar, showing how oxygenation influences glucose and insulin balance after 45.

You’ll hear how genes like PPARGC1A, SOD2, and NOS3 shape mitochondrial function, antioxidant defense, and blood flow — and why those factors can make the difference between clean, steady energy and afternoon crashes.

If you’ve noticed slower recovery, more fatigue, or brain fog that coffee doesn’t fix, this short episode helps you understand what’s happening at a cellular level — and how small shifts in movement, breathing, and sleep can help your energy stay steady.

Please share this episode with other women 45 + if you think they'd benefit from it.

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

Glucose and insulin come up often in health conversations, but many of us were never really taught how they work together. Once you understand that connection, things like mid-afternoon crashes and sudden cravings start to make a lot more sense.

In this episode, we look at the glucose–insulin relationship in simple, practical terms — and how genes like TCF7L2, FADS1, and PPARGC1A can influence how your body handles carbs, fats, and energy after 45.

You’ll hear why two people can eat the same meal and feel completely different, and what those differences reveal about your own metabolism.

If you’ve ever felt your energy crash a few hours after eating, this short episode helps you see what’s really happening — and how small, everyday shifts can bring your system back into balance.

Know someone 45+ who’d benefit? Share this.

After 45, energy balance depends on more than blood sugar — it depends on oxygen use inside your cells. The Oxygen Connection expands on this link and helps you see how small shifts in oxygen delivery improve glucose control and daily energy. 

Free resource:

It’s Not Just About Estrogen Levels

A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.

Get the guide here.

This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.