Your Genes by Design

Metabolic Flexibility: How Your Body Balances Glucose and Fat After 45


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Energy isn’t just about what you eat — it’s about how easily your body switches between glucose and fat for fuel. In this episode, we explore metabolic flexibility — the ability to shift between fuel sources — and why that flexibility becomes more important after 45.

You’ll hear how genes like PPARGC1A, FADS1, FADS2, and ADIPOQ shape insulin sensitivity, energy stability, and how efficiently your cells use the fuel you already have.

If you’ve noticed more hunger between meals, afternoon dips, or less steady energy than before, this short episode helps you understand why those changes happen — and what they reveal about your unique design.

Please share this episode with other women 45+ if you think they'd benefit from it.

🎧 Explore the free resource mentioned in this episode — The Oxygen Connection — for practical ways to support your energy system and balance glucose naturally.


If you’ve ever looked at lab results and felt like they didn’t fully explain what was happening in your body, you may find this helpful.

Download the free guide When “Normal” Lab Results Don’t Feel Normal, which explains how genomics adds context to bloodwork, hormone panels, and other health tests by showing how genes influence the body’s underlying processes.

Download the guide


This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.

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Your Genes by DesignBy Lauri Wakefield