Hva gjør du når tretinoin ikke fungerer – eller når forskningen faktisk viser økt dødelighet i en stor studie? I denne episoden går jeg gjennom hva som egentlig skjedde, hva tallene betyr, og hvorfor funnene fortsatt diskuteres. Vi ser også på adapalen: kan den faktisk måle seg med tretinoin når det gjelder rynker og pigmentering? Og til slutt: hvordan skiller vitamin C seg totalt fra retinoider – og hvorfor noen får dramatisk bedre effekt enn andre.
En episode for deg som vil forstå forskningen litt bedre.
Kilder:
Kang S, Goldfarb MT, Weiss JS, Metz RD, Hamilton TA, Voorhees JJ, Griffiths CE. Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial. J Am Acad Dermatol. 2003 Jul;49(1):83-90.
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Bagatin E, Gonçalves HS, Sato M, Almeida LMC, Miot HA. Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging. Eur J Dermatol. 2018 Jun 1;28(3):343-350.
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Lin L, Chen X, Liu C, Wang Q, Lian W, Xu X, Guo Y, Zhong H, Zhong J, Zhao N, Cheng W, Shu P, Xu Z. Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis. Sci Rep. 2025 Jul 24;15(1):26889.
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Sadick N, Pannu S, Abidi Z, Arruda S. Topical Treatments for Photoaged Skin. J Drugs Dermatol. 2023 Sep 1;22(9):867-873.
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Weinstock MA, Bingham SF, Lew RA, Hall R, Eilers D, Kirsner R, Naylor M, Kalivas J, Cole G, Marcolivio K, Collins J, Digiovanna JJ, Vertrees JE; Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial Group. Topical tretinoin therapy and all-cause mortality. Arch Dermatol. 2009 Jan;145(1):18-24.
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Shapiro S, Heremans A, Mays DA, Martin AL, Hernandez-Medina M, Lanes S. Use of topical tretinoin and the development of noncutaneous adverse events: evidence from a systematic review of the literature. J Am Acad Dermatol. 2011 Dec;65(6):1194-201.
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Berry K, Hallock K, Lam C. Photoaging and Topical Rejuvenation. Clin Plast Surg. 2023 Jul;50(3):381-390.
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Sachs DL, Rittié L, Chubb HA, Orringer J, Fisher G, Voorhees JJ. Hypo-collagenesis in photoaged skin predicts response to anti-aging cosmeceuticals. J Cosmet Dermatol. 2013 Jun;12(2):108-15. doi: 10.1111/jocd.12037.
Correia G, Magina S. Efficacy of topical vitamin C in melasma and photoaging: A systematic review. J Cosmet Dermatol. 2023 Jul;22(7):1938-1945. doi: 10.1111/jocd.15748.
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