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Hyaluronic acid is everywhere, in skincare, in supplements, and in injectable fillers. But do we really understand how it works?

Today, I explain what hyaluronic acid actually is, how it functions in our body, and why it is far more than just a “moisture magnet.” We discuss the difference between high and low molecular weight hyaluronic acid, how it behaves on the skin surface, and whether it can truly penetrate deeper layers. I also address important questions about oral supplementation, injectable fillers, and their long-term impact on skin aging. We explore the role of hyaluronic acid in inflammation, skin regeneration, and even active longevity research inspired by the naked mole rat. This is a science-based conversation about benefits, risks, and what realistic expectations should look like.

Learn more from the previous episodes:

The Truth About Skin Absorption and Safety

Episode resources:

Longevity gene from naked mole rats extends lifespan of mice

Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs

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