MrBeast and his team undertake a mission to find loving homes for 100 abandoned and rescued dogs from kill shelters. They set up a massive dog sanctuary, bringing in trainers, walkers, and a team dedicated to providing care and love to the dogs. Through various strategies, including a statewide ad campaign, offering free pet food and insurance for life, and celebrity appearances, they work to get every dog adopted. The video highlights the challenges of adopting out older and special needs dogs like Buffett, who has three legs. Ultimately, all 100 dogs find homes, and MrBeast provides additional surprises like cash rewards for adopters and a large donation to the dog sanctuary.