COVID-19 is a multisystem disease, and cardiac injury has been identified as a major contributor to the pathology.

Antoine Vieillard-Baron is an intensivist and researcher from Boulogne in France, and he joins the podcast to talk about key echocardiographic patterns of disease found in COVID-19

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Thrombotic microangiopathies are uncommon disorders, and can result in significant patient morbidity.  With the introduction of effective new therapies, the outlook for those suffering from these diseases is increasingly optimistic.

Elie Azoulay is a professor of medicine, intensivist and board member of the French National Reference Centre for Thrombotic Microangiopathies.

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Surgical site infections are a dreaded complication of all surgery, no more so than in cardiothoracics.  Antibiotics at the time of surgery has an established role in the prevention of infections, but the duration of therapy remains contentious.

The CALIPSO trial will explore different approaches to this question, and chief investigator Trisha Peel joins Todd on the podcast to discuss the issue.

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Does my patient need bolus IV crystalloid fluids?

This is a conundrum faced on a daily basis for clinicians working in the ICU.  As time goes by, more evidence of the harm fluids do becomes available, so how can we be sure the fluids we give benefit our patients?

Xavier Monnet is an intensivist and fluids researcher, and he joins Todd on the podcast to discuss fluid responsiveness.

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The development of antimicrobial agents is one of the most influential achievements of modern medicine. However, where once we thought the days of sepsis deaths could be numbered, antimicrobial resistance has given us pause for pessimism.

Professor Jan De Waele is a surgery-trained intensivist and clinical researcher from Ghent, Belgium, working on several aspects of optimizing antimicrobial use in the ICU, including Antimicrobial Stewardship.

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The impact of resuscitation strategies on the gut is often neglected, as attention to circulatory and respiratory support takes priority.

Leading ICU dietitian Varsha Asrani joins Todd to chat about the implications of gut ischaemia for the longterm recovery of our patients.

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Plasmapheresis can be a life saving intervention in a number of ICU conditions.  Two potential methods are available – centrifugal plasmapheresis and membrane therapeutic plasma exchange.  But what do we know about the applicability, utilisation and complications of the latter?

On this episode, Todd is joined by Mitul Chavda and Alpesh Patel, who recently published 6 years worth of prospective data from their service, run from the Flinders Medical Centre in South Australia.

Baxter Healthcare has provided an educational grant to sponsor this podcast. The content was developed independently of Baxter Healthcare and opinions expressed are those of the presenting healthcare professionals.

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Part 2 of this interview with CLIP-2 chief investigator Michael Reade explores the structure of CLIP-2, some of the challenges the project has had to overcome, and the workings of a non-inferiority trial.

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Platelets are a critical component of haemostatic resuscitation, but there are significant challenges involved in their use, most notably, their short shelf life.

Could frozen platelets be the answer?

Michael Reade is an anaesthetist, intensivist and clinical researcher from the University of Queensland and the Australian Defence Force, and he joins Todd to discuss his research program in this area, known as CLIP

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Ketamine is regarded as a bit of a wonder drug in emergency and critical care areas, but is it all that it’s cracked up to be.

Andrew Casamento is an Intensivist  / Emergency Physician at the Northern, Austin, Warringal Private and Bendigo Hospitals in Victoria, and is the author of a recent review of the role of ketamine in mechanically ventilated ICU patients.  He joins Todd on the podcast to discuss some of the important points.

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