Il sistema immunitario riveste un ruolo fondamentale durante lo sviluppo di un tumore. Se da un lato è un severo controllore che individua ed elimina sul nascere la maggior parte delle cellule alterate presenti nel nostro organismo, dall’altro, è in grado di creare un microambiente favorevole alla crescita e allo sviluppo di quelle pochissime cellule che riescono a sfuggire a questo controllo. Come avviene questo processo? E quali armi possiamo mettere in campo per contrastarlo?

(Registrato presso IFOM il 7 aprile 2016)

L'evento fa parte del ciclo di incontri organizzato da Youscientist, il programma divulgativo di IFOM, nel 2016.

Per info: https://www.ifom.eu/it/scienza-societa/conferenze-scientifiche/video-conferenze.php

Stefano Casola talks about the structure and the goals of the IFOM research program in Genome Diagnostics.

Recorded during the 1st Symposium IFOM-EMBL Monterotondo, June 2015

For more info visit https://www.ifom.eu/en/cancer-research/programs/genetics-bcells-lymphomas.php

Vincenzo Costanzo talks about vertebrate genome stability, focusing on the DNA replication and repair in vertebrate cells.

Additionally he discusses his research using extracts derived from Xenopus laevis eggs, which allow extensive biochemical analysis which can be reproduced in vitro complex cell cycle events such as chromatin formation, nuclear assembly, semi-conservative DNA replication, chromosome assembly and mitotic spindle formation.

Recorded during the 1st Symposium IFOM-EMBL Monterotondo, June 2015

For more info visit https://www.ifom.eu/en/cancer-research/programs/dna-metabolism.php

Elisabetta Dejana talks about her work on one of the innovative aspects of anti-cancer therapies, inhibiting tumour growth by blocking blood supply.

Her study takes a particular focus on brain tumours that currently don't have a effective treatment method.

Recorded during the 1st Symposium IFOM-EMBL Monterotondo, June 2015

For more info visit https://www.ifom.eu/en/cancer-research/programs/angiogenesis-cancer.php

Pier Paolo Di Fiore talks about his work looking at how stem cells can become cancer stem cells, as well as how differentiated cells can revert back to cancer cells, with particular reference to the role of p53.

Recorded during the 1st Symposium IFOM-EMBL Monterotondo, June 2015

For more info visit https://www.ifom.eu/en/cancer-research/programs/cellular-logistics-cancer.php

Valter Longo talks about his study of the positive effects of fasting, extreme diets and drugs that mimic them on the prevention and treatment of cancer.

Recorded during the 1st Symposium IFOM-EMBL Monterotondo, June 2015

For more info visit https://www.ifom.eu/en/cancer-research/programs/longevity-cancer.php

Giorgio Scita talks about his work looking at tumour cell migration and the ability of the tumour cells to use different motility modes to disseminate as well as allowing the cells to 'escape' pharmacotherapeutic intervention.

Recorded during the 1st Symposium IFOM-EMBL Monterotondo, June 2015

For more info visit https://www.ifom.eu/en/cancer-research/programs/mechanism-tumor-cell-migration.php

Marco Foiani talks about his study of the mechanisms which control chromosome integrity which in turn prevent genome instability and their pivotal importance for the cell.

Recorded during the 1st Symposium IFOM-EMBL Monterotondo, June 2015

For more info visit https://www.ifom.eu/en/cancer-research/programs/genome-integrity.php

Norbert Perrimon - James Stillman Professor of Developmental Biology, Department of Genetics, Harvard Medical School, Boston (MA-USA). For more info visit https://www.ifom.eu/en/

Le cellule hanno una straordinaria capacità di mantenere stabile nel tempo il loro genoma, ma a volte i meccanismi che tutelano l'integrità del DNA smettono di funzionare correttamente e le cellule accumulano mutazioni. Perché questo avviene? Quale relazione esiste tra mutazioni e cancro?

(Registrato presso IFOM il 22 aprile 2015) L'evento fa parte del ciclo di incontri organizzato da Youscientist, il programma divulgativo di IFOM, nel 2015.

Per info: https://www.ifom.eu/it/scienza-societa/conferenze-scientifiche/