The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode     Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) Engineering immune cells to treat cancer (Cell) Engineering T cells for fungal infections (PNAS) CAR T cells for AIDS (PLoS Path) CAR T cells (NIH) Image credit Letters read on Immune #4     Weekly Science Picks Cindy - What's In A Name? Steph - Novel Targets Vincent - Friendly Penguin Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Immune 4: Putting the immunotherapy CAR T before the cancer

A podcast about the body's defenders against disease.

Science

Life Sciences

Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,  gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode  MicrobeTV Discord Server Adaptive immune responses preserved in hypervaccinated individual (Lancet) Synthetically glycosylated antigens for antigen-specific suppression of established immune responses (Nat Biomed Eng) Gut bacteria–derived serotonin promotes immune tolerance in early life (Sci Immunol) Immune correlates of viral control after SARS-CoV-2 challenge in adults (Sci Immunol) Time stamps by Jolene. Thanks!  Music by Steve Neal. Immune logo image by Blausen Medical  Send your immunology questions and comments to immune@microbe.tv

Immune 78: Tolerance and tolerating many vaccines

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode  MicrobeTV Discord Server Trans endothelial migration activates neutrophil killing (Immunity) Time stamps by Jolene. Thanks!  Music by Steve Neal. Immune logo image by Blausen Medical  Send your immunology questions and comments to immune@microbe.tv

Immune 77: Squeezing the most killing out of neutrophils

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Guest: Juliet Morrison Click arrow to play Download Immune 76 (48 MB .mp3, 67 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode  MicrobeTV Discord Server Publishing is broken (Solving for Science) Pleural macrophages move to the lung during influenza (PNAS) Time stamps by Jolene. Thanks!  Music by Steve Neal Immune logo image by Blausen Medical  Send your immunology questions and comments to immune@microbe.tv

Immune 76: Macrophages to the rescue with Juliet Morrison

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Guest: Ang Cui Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode  MicrobeTV Discord Server Publishing is broken (Solving for Science) Immune Dictionary (Nature) Time stamps by Jolene. Thanks!  Music by Steve Neal. Immune logo image by Blausen Medical  Send your immunology questions and comments to immune@microbe.tv

Immune 75: Ang Cui unveils the cytokine symphony

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Carla R. Nowosad Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode  MicrobeTV Discord Server B cells and the intestinal microbiome (Sem Immunol) B cell selection in gut germinal centres (Nature) B cell antigen internalization (Methods Mol Biol) Immune synapse architecture (Nat Immunol) Time stamps by Jolene. Thanks!  Music by Steve Neal. Immune logo image by Blausen Medical  Send your immunology questions and comments to immune@microbe.tv

Immune 4: Putting the immunotherapy CAR T before the cancer

Download our free app to listen on your phone